Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
106
datasets available to search
ShareScore release 0.9.0
Dataset results
106 results for “Oxidative phosphorylation”
Data from: Sperm competitive advantage of a rare mitochondrial haplogroup linked to differential expression of mitochondrial oxidative phosphorylation genes
Maternal inheritance of mitochondria creates a sex-specific selective sieve through which mitochondrial mutations harmful to males but not females accumulate and contribute to sexual differences in longevity and disease susceptibility. Because eggs and sperm are under disruptive selection, sperm are predicted to be particularly vulnerable to the genetic load generated by maternal inheritance, yet evidence for mitochondrial involvement in male fertility is limited and controversial. Here, we exploit the coexistence of two divergent mitochondrial haplogroups (A and B2) in a Neotropical arachnid to investigate the role of mitochondria in sperm competition. DNA profiling demonstrated that B2-carrying males sired more than three times as many offspring in sperm competition experiments than A males, and this B2 competitive advantage cannot be explained by female mitochondrial haplogroup or male nuclear genetic background. RNA-Seq of testicular tissues implicates differential expression of mitochondrial oxidative phosphorylation (OXPHOS) genes in the B2 competitive advantage, including a 22-fold upregulation of <i>atp8</i> in B2 males. Previous comparative genomic analyses have revealed functionally significant amino acid substitutions in differentially expressed genes, indicating that the mitochondrial haplogroups differ not only in expression but also in DNA sequence and protein functioning. However, mitochondrial haplogroup had no effect on sperm number or sperm viability, and, when females were mated to a single male, neither male haplogroup, female haplogroup nor the interaction between male/female haplogroup significantly affected female reproductive success. Our findings therefore suggest that mitochondrial effects on male reproduction may often go undetected in noncompetitive contexts and may prove more important in nature than is currently appreciated.
Original data for publication: The Atomically Precise Gold/Captopril Nanocluster Au25(Capt)18 Gains Anticancer Activity by Inhibiting Mitochondrial Oxidative Phosphorylation
<p> Original data for publication: The Atomically Precise Gold/Captopril Nanocluster Au<sub>25</sub>(Capt)<sub>18</sub> Gains Anticancer Activity by Inhibiting Mitochondrial Oxidative Phosphorylation, ACS Applied Materials & Interfaces</p>
Oxidative Phosphorylation Inhibitor IACS-010759 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
ClinicalTrials.gov study NCT02882321. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Sperm competitive advantage of a rare mitochondrial haplogroup linked to differential expression of mitochondrial oxidative phosphorylation genes
Open the record for dataset details and reuse information.
Data from: Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and non-parallel physiological divergence
Across multiple lakes in North America, lake whitefish (Coregonus clupeaformis) have independently evolved "dwarf" and "normal" sympatric species pairs that exhibit pronounced phenotypic and genetic divergence. In particular, traits associated with metabolism have been shown to be highly differentiated between whitefish species. Here, we examine the transcription of genes associated with all five mitochondrial and nuclear genome-encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological mechanism responsible for the production of ATP, in whitefish species pairs from Cliff Lake and Webster Lake in Maine, USA. We observed OXPHOS gene transcription divergence between dwarf and normal whitefish in each of the two lakes, with the former exhibiting transcription upregulation for genes associated with each of the OXPHOS complexes. We also observed a significant influence of lake on transcription levels for some of the genes, indicating that inter-lake ecological or genetic differences are contributing to variation in OXPHOS gene transcription levels. Together, our results support the hypothesis that metabolic divergence is a critical adaptation involved in whitefish speciation, and implicate OXPHOS gene upregulation as a factor involved in meeting the enhanced energetic demands of dwarf whitefish. Further examination of the links between this critical physiological pathway and ecological and genetic variation will provide insight into the fine-scale evolutionary dynamics at work in nature.
Hedgehog induced oxidative phosphorylation rescues the neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease
<p>Hedgehog induced oxidative phosphorylation rescues the neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease</p>
Data from: Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy
Open the record for dataset details and reuse information.
Data from: Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and non-parallel physiological divergence
Open the record for dataset details and reuse information.
Data from: Stronger selective constraint on downstream genes in the oxidative phosphorylation pathway of cetaceans
Open the record for dataset details and reuse information.
A high-throughput screen reveals SALL4-induced oxidative phosphorylation vulnerabilities in cancer
GEO Series GSE114808. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Helicase-like transcription factor (HLTF)-deleted CDX/TME model of colorectal cancer increased transcription of oxidative phosphorylation genes and diverted glycolysis to boost S-glutathionylation in
GEO Series GSE234728. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing; Other.
Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, mcm functions, and iron homeostasis
GEO Series GSE148631. Danio rerio. 24 samples. Type: Expression profiling by high throughput sequencing.
Maternal overnutrition causes insulin resistance and alters skeletal muscle oxidative phosphorylation in adult rat offspring
GEO Series GSE49797. Rattus norvegicus. 11 samples. Type: Expression profiling by high throughput sequencing.
Crosstalk between eIF2α and eEF2 phosphorylation pathways optimizes translational arrest in response to oxidative stress
GEO Series GSE137409. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with global increases in H3K9me2 that do not suppress transcription
GEO Series GSE163300. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
circZFR promote lung carcinogenesis and oxidative phosphorylation by modulating alternative splicing
GEO Series GSE193064. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
IL-1 protects from fatal systemic candidiasis by inhibition of oxidative phosphorylation and hypoxia [bulk RNA-Seq]
GEO Series GSE282796. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
In vivo and in vitro matured oocytes from mice of advanced reproductive age exhibit alternative splicing processes for mitochondrial oxidative phosphorylation
GEO Series GSE182711. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Mutations in the SWI/SNF chromatin remodeling complex induce metabolic rewiring and dependence on oxidative phosphorylation [Affymetrix]
GEO Series GSE109010. Homo sapiens. 12 samples. Type: Expression profiling by array.
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
GEO Series GSE37344. Mus musculus. 3 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.