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11 results for “PAG”
Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility
<p>Foxb1-expressing neurons occur in the dorsal premammillary nucleus (PMd) and further rostrally in the parvafox nucleus, a longitudinal cluster of neurons in the lateral hypothalamus of rodents. The descending projection of these Foxb1+ neurons end in the dorsolateral part of the periaqueductal gray (dlPAG). The functional role of the Foxb1+ neuronal subpopulation in the PMd and the parvafox nucleus remains elusive. In this study, the activity of the Foxb1+ neurons and of their terminal endings in the dlPAG was selectively altered by employing chemo- and optogenetic tools. Our results show that in whole-body barometric plethysmography, hM3Dq-mediated, global Foxb1+ neuron excitation activates respiration. Time-resolved optogenetic gain-of-function manipulation of the terminal endings of Foxb1+ neurons in the rostral third of the dlPAG leads to abrupt immobility and bradycardia. Chemogenetic activation of Foxb1+ cell bodies and ChR2-mediated excitation of their axonal endings in the dlPAG led to a phenotypical presentation congruent with a "freezing-like" situation during innate defensive behavior. The authors have no relevant financial or non-financial interests to disclose. This work was supported by the Swiss National Foundation grant 31003A_160325 to Marco R. Celio.</p>
eor-1 and pag-3 mutants crossed to NeuroPAL
<p>Image volumes and annotations for eor-1 and pag-3 mutants crossed to NeuroPAL. Excel files are included with annotations for each image.</p> <p>The following image volumes and their annotations are provided for the NeuroPAL publication, "NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans". The publication is available here:<br> https://www.cell.com/cell/fulltext/S0092-8674(20)31682-2</p> <p>Please cite this work when using the images and their annotations.</p> <p>The image volumes are organized in 6 folders:</p> <p>- "eor-1 Control" = wild-type NeuroPAL[otIs669] controls<br> - "eor-1 cs28 x otIs669" = eor-1(cs28);NeuroPAL[otIs669] mutants<br> - "eor-1 ok1127 x otIs669" = eor-1(ok1127);NeuroPAL[otIs669] mutants</p> <p>- "pag-3 Control" = wild-type NeuroPAL[otIs669] controls<br> - "pag-3 n3098 x otIs669" = pag-3(n3098);NeuroPAL[otIs669] mutants<br> - "pag-3 ok488 x otIs669" = pag-3(ok488);NeuroPAL[otIs669] mutants</p> <p>These image files can be viewed with the NeuroPAL ID software, available at:<br> https://www.hobertlab.org/neuropal/<br> OR<br> https://github.com/amin-nejat/CELL_ID</p> <p> </p>
Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility
Open the record for dataset details and reuse information.
Fig. 4 in First record of North Italian roach, Leucos aula (Bonaparte, 1841) on the Pag Island, Croatia-relict of the last glacial maximum?
Fig. 4 Leucos aula (left lateral view) a HDBI 1525, Pag Island, Velo Blato, SL 70.1 mm, b NMW50699, Karin, SL 74.9 mm, and c NMW 84,857, Lago Campagna, Torino Prov., SL 65.9 mm
Fig. 1 Sampling sites and locations where L in First record of North Italian roach, Leucos aula (Bonaparte, 1841) on the Pag Island, Croatia-relict of the last glacial maximum?
Fig. 1 Sampling sites and locations where L. aula populations were recorded in Croatia
PAGER: constructing PAGs and new PAG–PAG relationships for network biology
<p>Pathway and Annotated-list Gene-signature Electronic Repository (PAGER) is an online systems biology tool for constructing and visualizing gene and PAG networks from multiple PAG genesets.</p> <p>PAG stands for Pathway, Annotated-list and Gene-signature. A PAG geneset represents a set of genes that share a common feature, whether they belong within the same pathway, share common biological processes, are co-differentially expressed under a particular condition of an experiment or clinical sample, or share a common downstream target or function.</p> <p><strong>Available at:</strong> <a href="http://discovery.informatics.uab.edu/PAGER">http://discovery.informatics.uab.edu/PAGER</a></p> <p><strong>Acknowledgements:</strong></p> <ul> <li> <p>Zongliang Yue, Qi Zheng, Michael T Neylon, Minjae Yoo, Jimin Shin, Zhiying Zhao, Aik Choon Tan, Jake Y Chen, PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology, Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D668–D676,<a href="https://doi.org/10.1093/nar/gkx1040">https://doi.org/10.1093/nar/gkx1040</a></p> </li> </ul> <p> </p> <p> </p> <p> </p> <p><strong>File description</strong></p> <p>The GMT file format is a tab delimited file format that describes gene sets. In the GMT format, each row represents a PAG. The first column is PAG identifier, the second column is PAG link and the third and left columns are PAG genes. </p>
A non-toxic analgesic elicits cell-specific genomic and epigenomic modulation by targeting the PAG brain region
GEO Series GSE286589. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Impact of Prevention Awareness Group (PAG) on Treatment Attendance and Drug Abstinence Among Substance User
ClinicalTrials.gov study NCT02173041. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Fig. 3 For L. aula specimens, a in First record of North Italian roach, Leucos aula (Bonaparte, 1841) on the Pag Island, Croatia-relict of the last glacial maximum?
Fig. 3 For L. aula specimens, a maximum likelihood phylogram was inferred. The nonparametric bootstrap support (50) is represented by the numbers on the branches. The trees are rooted in R. rutilus and S. cephalus as an outgroups
Fig. 2 in First record of North Italian roach, Leucos aula (Bonaparte, 1841) on the Pag Island, Croatia-relict of the last glacial maximum?
Fig. 2 The haplotye network is constructed from COI sequences of L. aula obtained in this study and from sequences publicly available in Gen- Bank. Colors denote sampling localities
Effect of intrauterine infusion of IFNT, PAG, or PAG and IFNT on luteal gene expression [in vivo]
GEO Series GSE279381. Bos taurus. 16 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.