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10 results for “PARP14”
Human Poly (ADP-ribose) Polymerase Family Member 14 (PARP14); A Target Enabling Package
<p>This work provides reagents to develop specific inhibitors of the macrodomains of PARP14, for potential use for cancer and/or inflammation. Targeting the macrodomains of PARP14 is an alternative targeting strategy to PARP catalytic domain inhibitors that may allow greater inhibitor selectivity, and an alternative cellular effect.</p> <p>This package includes protein purification protocols, crystal structures of the 2nd and 3rd macrodomain of PARP14 in complex with small molecule chemical starting points, <em>in vitro </em>assays to measure ligand binding to the macrodomains, as well as validation of a PARP14 antibody and reagents to generate PARP14 knock-out cell lines (CRISPR-Cas9).</p>
Data from: Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in replication fork stability controlled by ATR
<p>The DNA damage response is essential to maintain genomic stability, suppress replication stress, and protect against carcinogenesis. The ATR-CHK1 pathway is an essential component of this response, which regulates cell cycle progression in the face of replication stress. PARP14 is an ADP-ribosyltransferase with multiple roles in transcription, signaling, and DNA repair. To understand the biological functions of PARP14, we catalogued the genetic components that impact cellular viability upon loss of PARP14 by performing an unbiased, comprehensive, genome-wide CRISPR knockout genetic screen in PARP14-deficient cells. We uncovered the ATR-CHK1 pathway as essential for viability of PARP14-deficient cells, and identified regulation of DNA replication dynamics as an important mechanistic contributor to the synthetic lethality observed. Our work shows that PARP14 is an important modulator of the response to ATR-CHK1 pathway inhibitors.</p>
Data from: Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in replication fork stability controlled by ATR
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PARP14 is a Novel Target in STAT6 Mutant Follicular Lymphoma
GEO Series GSE208031. Homo sapiens. 54 samples. Type: Expression profiling by high throughput sequencing.
PARP14 controls the nuclear accumulation of a subset of type I Interferon-inducible proteins
GEO Series GSE100893. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis.
PARP14 controls the nuclear accumulation of a subset of type I Interferon-inducible proteins [reanalysis]
GEO Series GSE100890. Mus musculus. 0 samples. Type: Third-party reanalysis; Expression profiling by high throughput sequencing.
PARP14 controls the nuclear accumulation of a subset of type I Interferon-inducible proteins [ChIP-seq]
GEO Series GSE100884. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PARP14 controls the nuclear accumulation of a subset of type I Interferon-inducible proteins [RNA-seq2]
GEO Series GSE100887. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
PARP14 controls the nuclear accumulation of a subset of type I Interferon-inducible proteins [RNA-seq1]
GEO Series GSE100886. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Identification and characterization analysis of the different genes in primary mouse microglia response to ACT-PARP14 using RNA-seq.
GEO Series GSE152000. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.