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15
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ShareScore release 0.9.0
Dataset results
15 results for “PB1”
In-plane growth of topological crystalline insulator Pb1−xSnxTe nanowires
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Site entropy mapped to PB1 structure
<p>The influenza virus polymerase is central to influenza virus evolution. Adaptive mutations within the polymerase are often a prerequisite for efficient spread of novel animal-derived viruses in human populations. The polymerase also determines fidelity, and therefore the rate at which the virus will acquire mutations that lead to host range expansion, drug resistance, or antigenic drift. Despite its importance to viral replication and evolution, our understanding of the mutational effects and associated constraints on the influenza RNA-dependent RNA polymerase (RdRp) is relatively limited. We performed deep mutational scanning of the A/WSN/1933(H1N1) PB1, generating a library of 95.4% of amino acid substitutions at 757 sites. After accuracy filters, we were able to measure replicative fitness for 13,354 (84%) of all possible amino acid substitutions, and 13 were validated by results from pairwise competition assays. Functional and structural constraints were better revealed by individual sites involved in RNA or protein interactions than by major subdomains defined by sequence conservation. Mutational tolerance, as defined by site entropy, was correlated with evolutionary potential, as captured by diversity in available H1N1 sequences. Of 29 beneficial sites, many have either been identified in the natural evolution of PB1 or shown experimentally to have important impacts on replication and adaptation. Accessibility of amino acid substitutions by single nucleotide mutation was a key factor in determining whether mutations appeared in natural PB1 evolution. Our work provides a comprehensive map of mutational effects on a viral RdRp and a valuable resource for subsequent studies of influenza replication and evolution.</p>
Site entropy mapped to PB1 structure
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Detect genomic aberrations between PB1 and its counterpart, spindle-chromosome complex in human MII oocyte, PB2 and female pronucleus in human zygote at a single-cell level.
GEO Series GSE56676. Homo sapiens. 4 samples. Type: Genome variation profiling by genome tiling array.
Study of PB1-F2 functions in avian host.
GEO Series GSE56506. Gallus gallus. 10 samples. Type: Expression profiling by array.
Analysis of NS2-dependent effects on influenza PB1 segment extends replication requirements beyond the canonical promoter
GEO Series GSE276697. Influenza A virus (A/WSN/1933(H1N1)). 30 samples. Type: Other.
Transcriptome profiling of resistant NIL (PB1+Pi9) and susceptible rice line (PB1) 24 hours after M oryzae inoculation
GEO Series GSE81906. Oryza sativa. 12 samples. Type: Expression profiling by high throughput sequencing.
Overexpression of OsMADS29 in Oryza sativa var. PB1
GEO Series GSE42028. Oryza sativa. 6 samples. Type: Expression profiling by array.
Silencing of OsMADS29 in Oryza sativa var. PB1
GEO Series GSE42029. Oryza sativa. 6 samples. Type: Expression profiling by array.
HaCaT cells treated with bleogen pB1 or eGF
GEO Series GSE202512. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Comparitive transcriptome study of resistant NILs PB1+Pi1 and PB1+Pi54 and susceptible rice line (PB1) after M oryzae inoculation
GEO Series GSE117030. Oryza sativa. 24 samples. Type: Expression profiling by high throughput sequencing.
PB1
Irish Post Office Post Box Source: Objaverse 1.0 / Sketchfab
A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo
GEO Series GSE35940. Mus musculus. 43 samples. Type: Expression profiling by array.
ICL0011 - Host response in human Calu-3 cells to infection with A/Vietnam/1203-CIP048_RG3/2004 (H5N1) (PB1-F2 deletion), A/Vietnam/1203-CIP048_RG3/2004 (H5N1) (PB2-627E mutant) or WT: A/Vietnam/1203/2
GEO Series GSE43203. Homo sapiens. 60 samples. Type: Expression profiling by array.
IM006A - Mouse infection with PB1-F2del: A/Vietnam/1203-CIP048_RG3/2004 (H5N1) at 10^3 PFU
GEO Series GSE43302. Mus musculus. 31 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.