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36 results for “PFOS”
Ultrasound-driven degradation data for GenX, PFOA and PFOS at different ultrasonic frequencies and power densities
<p>The spreadsheet contains the individual and mixture degradation data for three different PFAS type representatives: PFOA, PFOS, and GenX.</p> <p>All PFAS stock solutions were prepared in ultrapure water.</p> <p>The data was generated by sampling from 500 mL batches of PFAS stock solutions irradiated with ultrasound at predetermined time intervals.</p> <p>The document contains separate tabs for the individual degradation of the 3 PFAS, as well as the mixture degradation data.</p> <p>In addition to PFAS concentrations, fluoride concentrations measured with an ion-selective electrode are shared.</p>
PFOS negatively impacts prey capture in larval zebrafish
<p>Per- and polyfluoroalkyl substances (PFAS) are widely used in many industrial and domestic applications. The wide range use of PFAS has resulted in unintentional human exposures and bioaccumulation in blood and other organs. Perfluorooctanesulfonate (PFOS) is among the most prevalent PFAS in the environment and has been postulated to affect brain functions in exposed organisms. However, the impacts of PFOS on early neural development have not been well-described. Here, we used zebrafish larvae to assess the effects of PFOS on two fundamental complex behaviors, prey capture and learning. Zebrafish exposed to PFOS concentrations ranging from 2 – 20 µM for differing 48-hour periods were viable through early larval stages. In addition, PFOS uptake was unaffected by the presence of a chorion. We employed two different experimental paradigms; we first assessed the impacts of increasing organismal PFOS bioaccumulation on prey capture and learning, and second, we probed stage-specific sensitivity to PFOS by exposing zebrafish at different developmental stages (0-2 vs 3-5 days post fertilization). Following both assays we measured the amount of PFOS present in each larva. PFOS levels varied in larvae from different groups within each experimental paradigm. Significant negative correlations were observed between larval PFOS accumulation and the percentage of captured prey, while non-significant negative correlations were observed between PFOS accumulation and experienced-induced prey capture learning. These findings suggest that PFOS accumulation negatively affects larval zebrafish's ability to perform complicated multisensory behaviors and highlight potential risks of PFOS exposure to animals in the wild, with implications for human health.</p>
PFOS negatively impacts prey capture in larval zebrafish
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Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation and Food Effect
ClinicalTrials.gov study NCT01072162. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Bioaccumulation of perfluorooctane sulfonic acid (PFOS) and oxidative stress in snapping turtles in New York, USA
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Data set for: Long-term Perfluorooctanesulfonic acid (PFOS) exposure alters anxiety-like behaviour but not boldness in zebrafish (Danio rerio)
<p>Perfluorooctanesulfonic acid (PFOS) is an organic pollutant that is commonly detected in wildlife, humans, and the environment. PFOS can cause a variety of toxic effects in zebrafish, however, the impact on complex behaviours like boldness and anxiety-like behaviour is unknown. To investigate the behavioural effects of PFOS in zebrafish, we exposed adult zebrafish to either 0, 0.1, or 1.0 mg/L PFOS for 40 days. After 20- and 40-days anxiety-like behaviour and boldness were assessed using the novel approach test and novel tank dive test, respectively. After 40- day exposure at a concentration of 1.0 mg/L, PFOS caused a significant increase in time spent in the upper zone and a significant decrease in time spent in the bottom zone of the novel tank dive test, suggesting decreased anxiety-like behaviour compared to controls. Neither 0.1 or 1.0 mg/L had an impact on zebrafish boldness at any time point. Exposure to 1.0 mg/L PFOS significantly decreased locomotion in the novel tank dive test after 20 days, whereas after 40 days there was no impact of PFOS on locomotion at any concentration, indicating potential short-term influences on locomotion. These results suggest chronic PFOS exposure can modulate anxiety-like behaviour, while exploratory activity and locomotion are not altered.</p>
Data set for: Long-term Perfluorooctanesulfonic acid (PFOS) exposure alters anxiety-like behaviour but not boldness in zebrafish (Danio rerio)
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Evaluation of PFHxS, PFOA, PFOS, and PFNA impact on liver metabolism using human liver spheroids
GEO Series GSE280527. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Cultured chicken embryonic hepatocytes (CEH) exposed to linear PFOS (L-PFOS), technical-grade PFOS (T-PFOS), or linear PFUdA
GEO Series GSE33291. Gallus gallus. 38 samples. Type: Expression profiling by array.
BRB-seq analysis of PFOS-induced thyroid hormone system disrupted rats reveal organ-specific effects
GEO Series GSE196133. Rattus norvegicus. 192 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA sequencing to reveal tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio)
GEO Series GSE275163. Danio rerio. 2 samples. Type: Expression profiling by high throughput sequencing.
Whole-genome transcriptome profiling in PFOS-treated uterine artery endothelial cells isolated from pregnant women
GEO Series GSE232176. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Unravelling the mechanisms of PFOS toxicity by combining morphological and transcriptomic analyses in zebrafish embryos
GEO Series GSE125072. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
PFOS exposure/diet effects on intestinal tissue
GEO Series GSE248402. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Perfluorooctane sulfonate (PFOS) exposure and alcohol-associated liver disease severity in a mouse chronic-binge ethanol feeding model
GEO Series GSE288842. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation
ClinicalTrials.gov study NCT01647659. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gene expression profiling in the lung and liver of Perfluorooctane sulfonate (PFOS) exposed mouse fetuses
GEO Series GSE13302. Mus musculus. 30 samples. Type: Expression profiling by array.
Calcium signaling as a possible mechanism behind increased locomotor response in zebrafish larvae exposed to a human relevant persistent organic pollutant mixture or PFOS
GEO Series GSE144525. Danio rerio. 20 samples. Type: Expression profiling by high throughput sequencing.
PFOS and PFHxS decrease lipoprotein production
GEO Series GSE22940. Mus musculus. 18 samples. Type: Expression profiling by array; Third-party reanalysis.
An 'omics approach to unraveling the paradoxical effect of diet on PFOS and PFNA induced NAFLD
GEO Series GSE138602. Mus musculus. 18 samples. Type: Expression profiling by array.
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Annotated Behaviour and Observability Dataset (ABODe)
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