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24 results for “PHIP”
Human Pleckstrin Homology domain Interacting Protein (PHIP); A Target Enabling Package
<p>SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.</p>
Pleckstrin Homology domain Interacting Protein (PHIP); A Target Enabling Package
<p>SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.</p>
X-ray structure ensemble refinement of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group P21212)
<p>X-ray structure ensemble refinement of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group P21212). Raw diffraction images are available on Zenodo: 10.5281/zenodo.4086066. A single conformer model was deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7AV8">7AV8</a>. Refinement was carried out with <a href="https://www.phenix-online.org/documentation/reference/ensemble_refinement.html">phenix.ensemble_refinement</a> and the repository contains all input and output files:</p> <p>Input:</p> <ul> <li>mx8421v63_xPHIPAx1521_free.mtz</li> <li>refine9.pdb</li> </ul> <p>Output:</p> <ul> <li>PHIPA-P21212_ensemble_refinement_ensemble.geo</li> <li>PHIPA-P21212_ensemble_refinement_ensemble.pdb</li> <li>PHIPA-P21212_ensemble_refinement_ensemble.mtz</li> <li>PHIPA-P21212_ensemble_refinement_ensemble.log</li> </ul>
Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq
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PhIP-Seq/VirScan Coronavirus phage display assay in maternal-infant dyads
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Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group C2)
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group C2). The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7AV9">7AV9</a>.</p> <p> </p> <p>Additional information:</p> <p>dataset: PHIPA-x1724<br> beamline: Diamond Light Source I04-1<br> visit: nt11175-63<br> date: 16-04-2015<br> Ω Start: 144.0°<br> Ω Osc: 0.12°<br> Ω Overlap: 0°<br> No. Images: 1500<br> Resolution: 1.50Å<br> Wavelength: 0.9173Å<br> Exposure: 0.040s<br> Transmission: 100.00%<br> Beamsize: 60x50μm</p>
Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group P212121)
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group P212121). The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7BBO">7BBO</a>.</p> <p> </p> <p>Additional information:</p> <p>dataset: PHIPA-x1738<br> beamline: Diamond Light Source I04-1<br> visit: nt11175-63<br> date: 16-04-2015<br> Ω Start: 90.0°<br> Ω Osc: 0.12°<br> Ω Overlap: 0°<br> No. Images: 1500<br> Resolution: 1.50Å<br> Wavelength: 0.9173Å<br> Exposure: 0.040s<br> Transmission: 100.00%<br> Beamsize: 60x50μm</p>
Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with H4K5acK8ac
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with H4K5acK8ac. The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7BBP">7BBP</a>.</p> <p> </p> <p>Additional information:</p> <p>dataset: PHIPA-x2179<br> beamline: Diamond Light Source I04-1<br> visit: mx10619-76<br> date: 20-06-2016<br> Ω Start: 216.3°<br> Ω Osc: 0.15°<br> Ω Overlap: 0°<br> No. Images: 1200<br> Resolution: 2.00Å<br> Wavelength: 0.9282Å<br> Exposure: 0.050s<br> Transmission: 100.00%</p>
Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group p21212)
<p>Raw diffraction images of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) (space group p21212). The final structure is deposited in the Protein Data Bank under accession code <a href="https://www.ebi.ac.uk/pdbe/entry/pdb/7AV8">7AV8</a>.</p> <p>Additional information:</p> <p>dataset: PHIPA-x152<br> beamline: Diamond Light Source I04-1<br> visit: mx8421-63<br> date: 02-03-2014<br> Ω Start: 90.0°<br> Ω Osc: 0.10°<br> Ω Overlap: 0°<br> No. Images: 1800<br> Resolution: 1.50Å<br> Wavelength: 0.9200Å<br> Exposure: 0.050s<br> Transmission: 100.00%<br> Beamsize: 60x50μm</p>
Data from: Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by PhIP-Seq
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Transcriptomic changes in THP1 human AML cell line on PHF6 knockout, PHF6R274Q mutation, PHIP knockout, and double knockout of PHF6 and PHIP compared to wildtype cells
GEO Series GSE281475. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic changes in PHF6 knockout THP1 human AML cell line on rescue with PHF6 wildtype (with and without PHIP) or rescue with PHF6R274Q mutant
GEO Series GSE281624. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles in the colon epithelia of the humanized CYP1A (hCYP1A) mice treated with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
GEO Series GSE165721. Mus musculus. 8 samples. Type: Expression profiling by array.
PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers [ChIP-seq]
GEO Series GSE299672. Homo sapiens. 132 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers [RNA-seq]
GEO Series GSE299562. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
PHIP suppresses NuRD to enable the growth of SWI/SNF-mutant cancers
GEO Series GSE315219. Homo sapiens. 174 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Particle Habit Imaging and Polar Scattering Probe (PHIPS) IMPACTS V1
The Particle Habit Imaging and Polar Scattering (PHIPS) Probes IMPACTS dataset consists of cloud particle imagery collected by the Particle Habit Imaging and Polar Scattering (PHIPS) probe onboard the NASA P-3 aircraft during the Investigation of Microphysics and Precipitation for Atlantic Coast-Threatening Snowstorms (IMPACTS) field campaign. IMPACTS was a three-year sequence of winter season deployments conducted to study snowstorms over the U.S. Atlantic Coast (2020-2023). The campaign aimed to (1) Provide observations critical to understanding the mechanisms of snowband formation, organization, and evolution; (2) Examine how the microphysical characteristics and likely growth mechanisms of snow particles vary across snowbands; and (3) Improve snowfall remote sensing interpretation and modeling to significantly advance prediction capabilities. PHIPS allows for the measurement of particle shape, size, and habit. The browse files in this dataset contain the post-processed particle-by-particle stereo images (2 images from different angles) collected by PHIPS during the campaign. The files are available from January 18, 2020, through February 28, 2023, in PNG format.
Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness
GEO Series GSE295715. Mus musculus; Homo sapiens. 90 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
PHIP occupancy in THP1 human AML cell line
GEO Series GSE281629. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Changes in H3K27 acetylation in THP1 human AML cell line on PHF6 knockout, PHF6R274Q mutation, PHIP knockout, and double knockout of PHF6 and PHIP compared to wildtype clones
GEO Series GSE281627. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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