Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
444
datasets available to search
ShareScore release 0.9.0
Dataset results
444 results for “PRC2”
Preliminary PRC2-HTT interaction study 2017/06/02
<p>Huntingtin structure-function open lab notebook project.</p>
PRC2-HTT interaction study 20170719
<p>Huntingtin structure-function open lab notebook project</p>
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
<p><span lang="EN-US">To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent transcripts by sequence complementarity, triggering the recruitment of histone methyltransferase enzymes on chromatin to repress the transcriptional activity of TEs and other repeats. In<span> the ciliate <em>Paramecium tetraurelia</em>,</span> 25-nt scnRNAs corresponding to TEs recruit Polycomb Repressive Complex 2 (PRC2), and trigger their elimination during the formation of the somatic nucleus. Here, we sequenced sRNAs during the entire sexual cycle with unprecedented resolution. Our data confirmed that scnRNAs are produced from the entire germline genome, from TEs and non-TE sequences, during meiosis. Non-TE scnRNAs are selectively degraded, which results in the specific selection of TE-scnRNAs. We demonstrate that PRC2 is essential for the selective degradation of non-TE-scnRNAs, independently of its histone methyltransferase activity. We further show that the PRC2 cofactor Rf4 mediates the physical interaction between the scnRNA-binding protein Ptiwi09 and the zinc finger protein Gtsf1, pointing to an architectural role of PRC2 in scnRNA degradation.</span></p>
Dataset: lhp1 FLC-Venus time course imaging – Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory
<p>The histone modification H3K27me3 plays a central role in Polycomb-mediated epigenetic silencing. H3K27me3 recruits and allosterically activates Polycomb Repressive Complex 2 (PRC2), which adds this modification to nearby histones, providing a read/write mechanism for inheritance through DNA replication. However, for some PRC2 targets, a purely histone-based system for epigenetic inheritance may be insufficient. We address this issue at the Polycomb target Flowering Locus C (FLC) in Arabidopsis thaliana, as a narrow nucleation region of only ~three nucleosomes within FLC mediates epigenetic state switching and subsequent memory over many cell cycles. To explain the memory's unexpected persistence, we introduce a mathematical model incorporating extra protein memory storage elements with positive feedback that persist at the locus through DNA replication, in addition to histone modifications. Our hybrid model explains many features of epigenetic switching/memory at FLC and encapsulates generic mechanisms that may be widely applicable.</p>
Dataset: lhp1 FLC-Venus time course imaging – Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory
Open the record for dataset details and reuse information.
HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia [722_RNA-seq]
GEO Series GSE187432. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia.
GEO Series GSE172088. Mus musculus. 69 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression
GEO Series GSE133722. Mus musculus. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Morphine leads to global genome changes of H3K27me3 levels in mESCs by a self-regulatory mechanism of Polycomb Repressive Complex 2 (PRC2)
GEO Series GSE151234. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation [RNA-seq]
GEO Series GSE221943. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Integrated Multiomic Profiling Identifies the Epigenetic Regulator PRC2 as a Therapeutic Target to Counteract Leukemia Immune Escape and Relapse [ATAC-seq]
GEO Series GSE197416. Homo sapiens. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Local inhibition of PRC2 activity by histone H3.3K27M drives replication defects through misregulation of the JNK pathway [ChIP-seq]
GEO Series GSE117531. Caenorhabditis elegans. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PRC2 mediates paternal epigenetic inheritance
GEO Series GSE68213. Mus musculus. 16 samples. Type: Expression profiling by array.
Accurate H3K27 methylation patterns can be established de novo by SUZ12-directed PRC2
GEO Series GSE103685. Mus musculus. 71 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia [763_ChIP-seq]
GEO Series GSE172086. Mus musculus. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The EZH2-PRC2-H3K27me3 axis governing the endometrial cell cycle and differentiation for successful blastocyst invasion
GEO Series GSE207362. Homo sapiens; Mus musculus. 87 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression [RNA-Seq]
GEO Series GSE133721. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma
GEO Series GSE183487. Homo sapiens. 77 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Variant PCGF1-PRC1 links PRC2 recruitment with induced transcriptional inactivation at target genes [RNA-seq]
GEO Series GSE141487. Mus musculus. 59 samples. Type: Expression profiling by high throughput sequencing.
ChIP-seq and RNA-seq analysis of PRC2 core subunits in primary human erythroid progenitor cells
GEO Series GSE59090. Homo sapiens. 30 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.