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44 results for “PRDM9”
Evolution of the recombination regulator PRDM9 in minke whales
<p>This data repository contains data and protocols for the manuscript: Evolution of the recombination regulator PRDM9 in minke whales</p>
Data from: Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice
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Data from: Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
Studies of highly diverged species have revealed two mechanisms by which meiotic recombination is directed to the genome—through PRDM9 binding or by targeting promoter-like features—that lead to dramatically different evolutionary dynamics of hotspots. Here, we identify PRDM9 orthologs from genome and transcriptome data in 225 species. We find the complete PRDM9 ortholog across distantly related vertebrates but, despite this broad conservation, infer a minimum of six partial and three complete losses. Strikingly, taxa carrying the complete ortholog of PRDM9 are precisely those with rapid evolution of its predicted binding affinity, suggesting that all domains are necessary for directing recombination. Indeed, as we show, swordtail fish carrying only a partial but conserved ortholog share recombination properties with PRDM9 knock-outs.
Data from: Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
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High prevalence of Prdm9-independent recombination hotspots in placental mammals
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Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features
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Multiple losses of aKRAB from PRDM9 coincide with a teleost-specific intron size distribution
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The Recombination Hotspot Paradox: Co-evolution between PRDM9 and its target sites: Mathematica Files
<p>Mathematica files used to draw the figures of the manuscript</p>
RPA and RAD51 ChIP-seq from genetically modified Dmc1-knockout B6xCAST PRDM9-Humanized/CAST mouse testes
GEO Series GSE239997. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PRDM9 activity depends on HELLS and promotes 5-Hydroxymethylcytosine enrichment
GEO Series GSE145768. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
DMC1 ChIP-seq from B6xCAST F1 PRDM9-Humanized/CAST testes
GEO Series GSE124991. Mus musculus. 3 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing.
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [RNA-seq]
GEO Series GSE262251. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
HELLS and PRDM9 from a pioneer complex to open chromatin at meiotic recombination hotspots
GEO Series GSE135896. Mus musculus. 51 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks
GEO Series GSE132446. Mus musculus. 186 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
H3K4me3 ChIP-seq from B6CASTF1-PRDM9 Humanized/CAST testes
GEO Series GSE119727. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide map of H3K4me3 and PRDM9-binding in 12 day post-partum mouse spermatocytes
GEO Series GSE60906. Mus musculus. 26 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Sexual dimorphism in the meiotic requirement for PRDM9: a mammalian evolutionary safeguard
GEO Series GSE144144. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis; Other.
Crossovers from B6xCAST F1 PRDM9-Humanized/CAST testes
GEO Series GSE125326. Mus musculus. 219 samples. Type: Genome variation profiling by high throughput sequencing.
EWSR1 regulates PRDM9-dependent histone 3 methylation and links recombinant hotspots to the chromosomal axis
GEO Series GSE108259. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage
GEO Series GSE61613. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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