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ShareScore release 0.9.0
Dataset results
16 results for “Pexidartinib”
Study of Pexidartinib in Participants With Moderate Hepatic Impairment Compared With Healthy Participants
ClinicalTrials.gov study NCT04223635. IPD Sharing: YES. Countries: 1. Publications: 1.
Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)
ClinicalTrials.gov study NCT02371369. IPD Sharing: YES. Countries: 12. Publications: 5.
A Study of the Efficacy and Safety of Pexidartinib in Adult Subjects With TGCT
ClinicalTrials.gov study NCT04488822. IPD Sharing: YES. Countries: 2. Publications: 1.
Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)
ClinicalTrials.gov study NCT03291288. IPD Sharing: YES. Countries: 4. Publications: 1.
Supplemental information for: Inhibition of CSF1R and KIT with pexidartinib reduces inflammatory signaling and cell viability in endometriosis
<p>Endometriosis is a common and debilitating disease, affecting ~170 million women worldwide. Affected patients have limited therapeutic options such as hormonal suppression or surgical excision of the lesions, though therapies are often not completely curative. Targeting receptor tyrosine-kinases (RTKs) could provide a nonhormonal treatment option for endometriosis. We determined that two RTKs, Macrophage colony stimulating factor receptor (CSF1R) and Mast/stem cell growth factor receptor KIT (KIT), are overexpressed in endometriotic lesions and could be novel nonhormonal therapeutic targets for endometriosis. The kinase activity of CSF1R and KIT is suppressed by pexidartinib, a small molecule inhibitor that was recently approved by the US Food and Drug Administration (FDA). Using immunohistochemistry, we detected CSF1R and KIT in endometriotic tissues obtained from peritoneal lesions, colorectal lesions, and endometriomas. Specifically, we show that KIT is localized to the epithelium of the lesions, while CSF1R is expressed in the stroma and macrophages of the endometriotic lesions. Given the high epithelial expression of CSF1R and KIT, 12Z endometriotic epithelial cells were used to evaluate the efficacy of dual CSF1R and KIT inhibition with pexidartinib. We found that pexidartinib suppressed activation in 12Z cells of JNK, STAT3 and AKT signaling pathways, which control key pro-inflammatory and survival networks within the cell. Using quantitative real time PCR, we determined that pexidartinib suppressed interleukin 8 (<em>IL8) </em>and cyclin D1 (<em>CCND1) </em>expression<em>.</em> Lastly, we demonstrated that pexidartinib decreased cell growth and viability.<em> </em>Overall, these results indicate that pexidartinib-mediated CSF1R and KIT inhibition reduces pro-inflammatory signaling and cell viability in endometriosis.</p>
CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors
ClinicalTrials.gov study NCT02401815. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Pexidartinib in Asian Subjects With Advanced Solid Tumors
ClinicalTrials.gov study NCT02734433. IPD Sharing: NO. Countries: 1. Publications: 2.
Supplemental information for: Inhibition of CSF1R and KIT with pexidartinib reduces inflammatory signaling and cell viability in endometriosis
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Effect of Probenecid on Pexidartinib Pharmacokinetics
ClinicalTrials.gov study NCT03138759. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate Discontinuation and Re-Treatment in Participants With Tenosynovial Giant Cell Tumor (TGCT) Previously Treated With Pexidartinib
ClinicalTrials.gov study NCT04526704. IPD Sharing: YES. Countries: 7. Publications: 0.
Effect of Low-Fat Food on Pexidartinib Pharmacokinetics in Healthy Volunteers
ClinicalTrials.gov study NCT03901313. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST)
ClinicalTrials.gov study NCT03158103. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Evaluation of Safety and Activity of an Anti-PDL1 Antibody (DURVALUMAB) Combined With CSF-1R TKI (PEXIDARTINIB) in Patients With Metastatic/Advanced Pancreatic or Colorectal Cancers
ClinicalTrials.gov study NCT02777710. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Pexidartinib in Tenosynovial Giant Cell Tumor in Japan
ClinicalTrials.gov study NCT04703322. IPD Sharing: NO. Countries: 1. Publications: 0.
A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment
ClinicalTrials.gov study NCT04635111. IPD Sharing: YES. Countries: 1. Publications: 0.
Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neu
ClinicalTrials.gov study NCT02390752. IPD Sharing: YES. Countries: 1. Publications: 0.
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