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PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWL (v2.0.0 - January 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Class-Standard Relations-OWLBuild Date: January 25, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWLNETS (v2.0.0 - May 2020)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Instance-InverseRelations-OWLNETSBuild Date: May 10, 2020 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWLNETS (v2.0.0 - January 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Instance-Standard Relations-OWLNETSBuild Date: January 25, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>

opencc-by-4.0Jan 2012View details →

PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWLNETS (v2.0.0 - January 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Instance-Inverse Relations-OWLNETSBuild Date: January 25, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWL (v2.0.0 - May 2020)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Instance-StandardRelations-OWLBuild Date: May 10, 2020 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWLNETS (v2.0.0 - May 2020)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Instance-StandardRelations-OWLNETSBuild Date: May 10, 2020 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWL (v2.0.0 - May 2020)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Instance-InverseRelations-OWLBuild Date: May 10, 2020 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWL (v2.0.0 - January 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Class-Inverse Relations-OWLBuild Date: January 25, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWLNETS (v2.0.0 - May 2020)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Class-InverseRelations-OWLNETSBuild Date: May 10, 2020 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWLNETS (v2.0.0 - January 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Class-Standard Relations-OWLNETSBuild Date: January 25, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWLNETS (v2.0.0 - January 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Class-Inverse Relations-OWLNETSBuild Date: January 25, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>

opencc-by-4.0Jan 2012View details →

PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWL (v2.0.0 - January 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Instance-Inverse Relations-OWLBuild Date: January 25, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWL (v2.0.0 - May 2020)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Class-InverseRelations-OWLBuild Date: May 10, 2020 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>

PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWLNETS (v2.0.0 - May 2020)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)Build Type: Class-Standard Relations-OWLNETSBuild Date: May 10, 2020 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>

PheKnowLator Human Disease Knowledge Graphs - Build Data (Processed)

RELEASE V2.1.0 KNOWLEDGE GRAPH: PROCESSED DATA SOURCES  Release: <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2.0.0">v2.1.0 </a> The goal of this build was to create a knowledge graph that represented human disease mechanisms and included the central dogma. The data sources utilized in this release include many of the sources used in the initial release, as well as some new data made available by the <a href="https://ctdbase.org/">Comparative Toxicogenomics Database</a> and experimental data from the <a href="https://www.proteinatlas.org/">Human Protein Atlas</a>. Data sources are listed by type (Ontology and Data not represented in an ontology [Database Sources]). Additional details are provided for each data source below. Please see documentation on the primary release (<a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources">https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources</a>) for additional details on each data source as well as citation information. Data Access: <ul> <li><a href="https://console.cloud.google.com/storage/browser/pheknowlator/archived_builds/release_v2.1.0/build_01MAY2021?project=pheknowlator">https://console.cloud.google.com/storage/browser/pheknowlator/archived_builds/release_v2.1.0/build_01MAY2021</a></li> </ul>   ONTOLOGIES <ul> <li>Cell Ontology</li> <li>Cell Line Ontology</li> <li>Chemical Entities of Biological Interest (ChEBI) Ontology</li> <li>Gene Ontology</li> <li>Human Phenotype Ontology</li> <li>Mondo Disease Ontology</li> <li>Pathway Ontology</li> <li>Protein Ontology</li> <li>Relations Ontology</li> <li>Sequence Ontology</li> <li>Uber-Anatomy Ontology</li> <li>Vaccine Ontology</li> </ul>   Cell Ontology (CL) Homepage: <a href="https://github.com/obophenotype/cell-ontology"><code>GitHub</code></a> Citation: <blockquote> Bard J, Rhee SY, Ashburner M. <a href="https://genomebiology.biomedcentral.com/articles/10.1186/gb-2005-6-2-r21">An ontology for cell types</a>. Genome Biology. 2005;6(2):R21 </blockquote> Usage: Utilized to connect <code>transcripts</code> and <code>proteins</code> to <code>cells</code>. Additionally, the edges between this ontology and its dependencies are utilized: <ul> <li><a href="https://www.ebi.ac.uk/chebi/"><code>ChEBI</code></a></li> <li><a href="http://geneontology.org/"><code>GO</code></a></li> <li><a href="https://github.com/pato-ontology/pato/"><code>PATO</code></a></li> <li><a href="https://proconsortium.org/"><code>PRO</code></a></li> <li><a href="https://github.com/oborel/obo-relations/"><code>RO</code></a></li> <li><a href="https://uberon.github.io/"><code>UBERON</code></a></li> </ul>   Cell Line Ontology (CLO) Homepage: <a href="http://www.clo-ontology.org/"><code>http://www.clo-ontology.org/</code></a> Citation: <blockquote> Sarntivijai S, Lin Y, Xiang Z, Meehan TF, Diehl AD, Vempati UD, Schürer SC, Pang C, Malone J, Parkinson H, Liu Y. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387853/">CLO: the cell line ontology</a>. Journal of Biomedical Semantics. 2014;5(1):37 </blockquote> Usage: Utilized this ontology to map <code>cell lines</code> to <code>transcripts</code> and <code>proteins</code>. Additionally, the edges between this ontology and its dependencies are utilized: <ul> <li><a href="http://www.obofoundry.org/ontology/cl.html"><code>CL</code></a></li> <li><a href="http://disease-ontology.org/"><code>DOID</code></a></li> <li><a href="https://github.com/obophenotype/ncbitaxon"><code>NCBITaxon</code></a></li> <li><a href="https://uberon.github.io/"><code>UBERON</code></a></li> </ul>   Chemical Entities of Biological Interest (ChEBI) Homepage: <a href="https://www.ebi.ac.uk/chebi/"><code>https://www.ebi.ac.uk/chebi/</code></a> Citation: <blockquote> Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. <a href="https://academic.oup.com/nar/article-abstract/44/D1/D1214/2502583">ChEBI in 2016: Improved services and an expanding collection of metabolites</a>. Nucleic Acids Research. 2015;44(D1):D1214-9 </blockquote> Usage: Utilized to connect <code>chemicals</code> to <code>complexes</code>, <code>diseases</code>, <code>genes</code>, <code>GO biological processes</code>, <code>GO cellular components</code>, <code>GO molecular functions</code>, <code>pathways</code>, <code>phenotypes</code>, <code>reactions</code>, and <code>transcripts</code>.   Gene Ontology (GO) Homepage: <a href="http://geneontology.org/"><code>http://geneontology.org/</code></a> Citations: <blockquote> Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA. <a href="https://www.nature.com/articles/ng0500_25">Gene ontology: tool for the unification of biology</a>. Nature Genetics. 2000;25(1):25 The Gene Ontology Consortium. <a href="https://academic.oup.com/nar/article/47/D1/D330/5160994">The Gene Ontology Resource: 20 years and still GOing strong</a>. Nucleic Acids Research. 2018;47(D1):D330-8 </blockquote> Usage: Utilized to connect <code>biological processes</code>, <code>cellular components</code>, and <code>molecular functions</code> to <code>chemicals</code>, <code>pathways</code>, and <code>proteins</code>. Additionally, the edges between this ontology and its dependencies are utilized: <ul> <li><a href="http://www.obofoundry.org/ontology/cl.html"><code>CL</code></a></li> <li><a href="https://github.com/obophenotype/ncbitaxon"><code>NCBITaxon</code></a></li> <li><a href="https://github.com/oborel/obo-relations/"><code>RO</code></a></li> <li><a href="https://uberon.github.io/"><code>UBERON</code></a></li> </ul> Other Gene Ontology Data Used: <a href="http://geneontology.org/gene-associations/goa_human.gaf.gz"><code>goa_human.gaf.gz</code></a>   Human Phenotype Ontology (HPO) Homepage: <a href="https://hpo.jax.org/"><code>https://hpo.jax.org/</code></a> Citation: <blockquote> Köhler S, Carmody L, Vasilevsky N, Jacobsen JO, Danis D, Gourdine JP, Gargano M, Harris NL, Matentzoglu N, McMurry JA, Osumi-Sutherland D. <a href="https://academic.oup.com/nar/article-abstract/47/D1/D1018/5198478">Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources</a>. Nucleic Acids Research. 2018;47(D1):D1018-27 </blockquote> Usage: Utilized to connect <code>phenotypes</code> to <code>chemicals</code>, <code>diseases</code>, <code>genes</code>, and <code>variants</code>. Additionally, the edges between this ontology and its dependencies are utilized: <ul> <li><a href="http://www.obofoundry.org/ontology/cl.html"><code>CL</code></a></li> <li><a href="https://www.ebi.ac.uk/chebi/"><code>ChEBI</code></a></li> <li><a href="http://geneontology.org/"><code>GO</code></a></li> <li><a href="https://uberon.github.io/"><code>UBERON</code></a></li> </ul> Files <ul> <li>Other Human Phenotype Ontology Data Used: <a href="http://purl.obolibrary.org/obo/hp/hpoa/phenotype.hpoa"><code>phenotype.hpoa</code></a></li> </ul>   Mondo Disease Ontology (Mondo) Homepage: <a href="https://mondo.monarchinitiative.org/"><code>https://mondo.monarchinitiative.org/</code></a> Citation: <blockquote> Mungall CJ, McMurry JA, Köhler S, Balhoff JP, Borromeo C, Brush M, Carbon S, Conlin T, Dunn N, Engelstad M, Foster E. <a href="https://academic.oup.com/nar/article-abstract/45/D1/D712/2605791">The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species</a>. Nucleic Acids Research. 2017;45(D1):D712-22 </blockquote> Usage: Utilized to connect <code>diseases</code> to <code>chemicals</code>, <code>phenotypes</code>, <code>genes</code>, and <code>variants</code>. Additionally, the edges between this ontology and its dependencies are utilized: <ul> <li><a href="http://www.obofoundry.org/ontology/cl.html"><code>CL</code></a></li> <li><a href="https://www.ncbi.nlm.nih.gov/taxonomy"><code>NCBITaxon</code></a></li> <li><a href="http://geneontology.org/"><code>GO</code></a></li> <li><a href="https://hpo.jax.org/"><code>HPO</code></a></li> <li><a href="https://uberon.github.io/"><code>UBERON</code></a></li> </ul>   Pathway Ontology (PW) Homepage: <a href="https://rgd.mcw.edu/wg/home/pathway2/"><code>rgd.mcw.edu</code></a> Citation: <blockquote> Petri V, Jayaraman P, Tutaj M, Hayman GT, Smith JR, De Pons J, Laulederkind SJ, Lowry TF, Nigam R, Wang SJ, Shimoyama M. <a href="https://www.ncbi.nlm.nih.gov/pubmed/24499703">The pathway ontology–updates and applications</a>. Journal of Biomedical Semantics. 2014;5(1):7. </blockquote> Usage: Utilized to connect <code>pathways</code> to <code>GO biological processes</code>, <code>GO cellular components</code>, <code>GO molecular functions</code>, <code>Reactome pathways</code>. Several steps are taken in order to connect <code>Pathway Ontology</code> identifiers to <code>Reactome</code> pathways and <code>GO biological processes</code>. To connect <code>Pathway Ontology</code> identifiers to <code>Reactome</code> pathways, we use <a href="https://github.com/ComPath/resources/tree/master/mappings">ComPath Pathway Database Mappings</a> developed by Daniel Domingo-Fernández (<a href="https://www.ncbi.nlm.nih.gov/pubmed/30564458">PMID:30564458</a>). Files <ul> <li>Downloaded Mapping Data <ul> <li><a href="http://compath.scai.fraunhofer.de/export_mappings"><code>curated_mappings.txt</code></a></li> <li><a href="https://github.com/ComPath/resources/blob/master/mappings/kegg_reactome.csv"><code>kegg_reactome.csv</code></a></li> </ul> </li> <li>Generated Mapping Data <ul> <li><a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/REACTOME_PW_GO_MAPPINGS.txt"><code>REACTOME_PW_GO_MAPPINGS.txt</code></a></li> </ul> </li> </ul>   Protein Ontology (PRO) Homepage: <a href="https://proconsortium.org/"><code>https://proconsortium.org/</code></a> Citation: <blockquote> Natale DA, Arighi CN, Barker WC, Blake JA, Bult CJ, Caudy M, Drabkin HJ, D’Eustachio P, Evsikov AV, Huang H, Nchoutmboube J. <a href="https://academic.oup.com/nar/article-abstract/39/suppl_1/D539/2508558">The Protein Ontology: a structured representation of protein forms and complexes</a>. Nucleic Acids Research. 2010;39(suppl_1):D539-45 </blockquote> Usage: Utilized to connect <code>proteins</code> to <code>chemicals</code>, <code>genes</code>, <code>anatomy</code>, <code>catalysts</code>, <code>cell lines</code>, <code>cofactors</code>, <code>complexes</code>, <code>GO biological processes</code>, <code>GO cellular components</code>, <code>GO molecular functions</code>, <code>pathways</code>, <code>proteins</code>, <code>reactions</code>, and <code>transcripts</code>. Additionally, the edges between this ontology and its dependencies are utilized: <ul> <li><a href="https://www.ebi.ac.uk/chebi/"><code>ChEBI</code></a></li> <li><a href="http://disease-ontology.org/"><code>DOID</code></a></li> <li><a href="http://geneontology.org/"><code>GO</code></a></li> </ul> Notes: A partial, human-only version of this ontology was used. Details on how this version of the ontology was generated can be found under the Protein Ontology section of the <a href="https://github.com/callahantiff/PheKnowLator/blob/master/notebooks/Data_Preparation.ipynb"><code>Data_Preparation.ipynb</code></a> Jupyter Notebook. Files <ul> <li> Generated Human Version Protein Ontology (PRO) <ul> <li><a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/human_pro.owl"><code>human_pro.owl</code></a> (closed with <a href="http://www.hermit-reasoner.com/">hermit reasoner</a>)</li> </ul> </li> <li> Other PRO Data Used: <a href="https://proconsortium.org/download/current/promapping.txt"><code>promapping.txt</code></a> </li> <li> Generated Mapping Data <ul> <li>Merged Gene, RNA, Protein Map: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/Merged_gene_rna_protein_identifiers.pkl"><code>Merged_gene_rna_protein_identifiers.pkl</code></a></li> <li>Ensembl Transcript-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENTREZ_GENE_ENSEMBL_TRANSCRIPT_MAP.txt"><code>ENSEMBL_TRANSCRIPT_PROTEIN_ONTOLOGY_MAP.txt</code></a></li> <li>Entrez Gene-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENTREZ_GENE_PRO_ONTOLOGY_MAP.txt"><code>ENTREZ_GENE_PRO_ONTOLOGY_MAP.txt</code></a></li> <li>UniProt Accession-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/UNIPROT_ACCESSION_PRO_ONTOLOGY_MAP.txt"><code>UNIPROT_ACCESSION_PRO_ONTOLOGY_MAP.txt</code></a></li> <li>STRING-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/STRING_PRO_ONTOLOGY_MAP.txt"><code>STRING_PRO_ONTOLOGY_MAP.txt</code></a></li> </ul> </li> </ul>   Relations Ontology (RO) Homepage: <a href="https://github.com/oborel/obo-relations/"><code>GitHub</code></a> Citation: <blockquote> Smith B, Ceusters W, Klagges B, Köhler J, Kumar A, Lomax J, Mungall C, Neuhaus F, Rector AL, Rosse C. <a href="https://genomebiology.biomedcentral.com/articles/10.1186/gb-2005-6-5-r46">Relations in biomedical ontologies</a>. Genome Biology. 2005;6(5):R46. </blockquote> Usage: Utilizing this ontology to connect all data sources in knowledge graph. Additionally, the ontology is queried prior to building the knowledge graph to identify all relations, their inverse properties, and their labels. Files <ul> <li>Generated RO Data <ul> <li><a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/INVERSE_RELATIONS.txt"><code>INVERSE_RELATIONS.txt</code></a></li> <li><a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/RELATIONS_LABELS.txt"><code>RELATIONS_LABELS.txt</code></a></li> </ul> </li> </ul>   Sequence Ontology (SO) Homepage: <a href="https://github.com/The-Sequence-Ontology/SO-Ontologies"><code>GitHub</code></a> Citation: <blockquote> Eilbeck K, Lewis SE, Mungall CJ, Yandell M, Stein L, Durbin R, Ashburner M. <a href="https://link.springer.com/article/10.1186/gb-2005-6-5-r44">The Sequence Ontology: a tool for the unification of genome annotations</a>. Genome Biology. 2005;6(5):R44 </blockquote> Usage: Utilized to connect <code>transcripts</code> and other genomic material like <code>genes</code> and <code>variants</code>. Files <ul> <li>Generated Mapping Data <ul> <li><a href="https://storage.googleapis.com/pheknowlator/curated_data/genomic_sequence_ontology_mappings.xlsx"><code>genomic_sequence_ontology_mappings.xlsx</code></a></li> <li><a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/SO_GENE_TRANSCRIPT_VARIANT_TYPE_MAPPING.txt"><code>SO_GENE_TRANSCRIPT_VARIANT_TYPE_MAPPING.txt</code></a></li> </ul> </li> </ul>   Uber-Anatomy Ontology (Uberon) Homepage: <a href="https://uberon.github.io/"><code>GitHub</code></a> Citation: <blockquote> Mungall CJ, Torniai C, Gkoutos GV, Lewis SE, Haendel MA. <a href="https://genomebiology.biomedcentral.com/articles/10.1186/gb-2012-13-1-r5">Uberon, an integrative multi-species anatomy ontology</a>. Genome Biology. 2012;13(1):R5 </blockquote> Usage: Utilized to connect <code>tissues</code>, <code>fluids</code>, and <code>cells</code> to <code>proteins</code> and <code>transcripts</code>. Additionally, the edges between this ontology and its dependencies are utilized: <ul> <li><a href="https://www.ebi.ac.uk/chebi/"><code>ChEBI</code></a></li> <li><a href="http://www.obofoundry.org/ontology/cl.html"><code>CL</code></a></li> <li><a href="http://geneontology.org/"><code>GO</code></a></li> <li><a href="https://proconsortium.org/"><code>PRO</code></a></li> </ul>   Vaccine Ontology (VO) Homepage: <a href="http://www.violinet.org/vaccineontology/"><code>http://www.violinet.org/vaccineontology/</code></a> Citations: <blockquote> He Y, Racz R, Sayers S, Lin Y, Todd T, Hur J, Li X, Patel M, Zhao B, Chung M, Ostrow J. <a href="https://academic.oup.com/nar/article-abstract/42/D1/D1124/1053128">Updates on the web-based VIOLIN vaccine database and analysis system</a>. Nucleic Acids Research. 2013;42(D1):D1124-32 Xiang Z, Todd T, Ku KP, Kovacic BL, Larson CB, Chen F, Hodges AP, Tian Y, Olenzek EA, Zhao B, Colby LA. <a href="https://academic.oup.com/nar/article-abstract/36/suppl_1/D923/2505793">VIOLIN: vaccine investigation and online information network</a>. Nucleic Acids Research. 2007;36(suppl_1):D923-8 </blockquote> Usage: Utilized the edges between this ontology and its dependencies: <ul> <li><a href="https://www.ebi.ac.uk/chebi/"><code>ChEBI</code></a></li> <li><a href="http://disease-ontology.org/"><code>DOID</code></a></li> <li><a href="http://geneontology.org/"><code>GO</code></a></li> <li><a href="https://proconsortium.org/"><code>PRO</code></a></li> <li><a href="https://uberon.github.io/"><code>UBERON</code></a></li> </ul>   DATABASE SOURCES <ul> <li>BioPortal</li> <li>ClinVar</li> <li>Comparative Toxicogenomics Database</li> <li>DisGeNET</li> <li>Ensembl</li> <li>GeneMANIA</li> <li>Genotype-Tissue Expression Project</li> <li>Human Genome Organisation Gene Nomenclature Committee</li> <li>Human Protein Atlas</li> <li>National Center for Biotechnology Information Gene</li> <li>Reactome Pathway Database</li> <li>Search Tool for Recurring Instances of Neighbouring Genes Database</li> <li>Universal Protein Resource Knowledgebase</li> </ul>   BioPortal Homepage: <a href="https://bioportal.bioontology.org/"><code>BioPortal</code></a> Citation: <blockquote> BioPortal. <a href="https://www.bioontology.org/wiki/LOOM">Lexical OWL Ontology Matcher (LOOM)</a> Ghazvinian A, Noy NF, Musen MA. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2815474/">Creating mappings for ontologies in biomedicine: simple methods work</a>. In AMIA Annual Symposium Proceedings 2009 (Vol. 2009, p. 198). American Medical Informatics Association </blockquote> Usage: BioPortal was utilized to obtain mappings between <code>MeSH identifiers</code> and <code>ChEBI identifiers</code> for <code>chemicals-diseases</code>, <code>chemicals-genes</code>, <code>chemical-GO biological processes</code>, <code>chemicals-GO cellular components</code>, <code>chemicals-GO molecular functions</code>, <code>chemicals-phenotypes</code>, <code>chemicals-proteins</code>, and <code>chemicals-transcripts</code>. Additional information on how this data was processed can be obtained from the <a href="https://gist.github.com/callahantiff/a28fb3160782f42f104e9ec41553af0d"><code>NCBO_rest_api.py</code></a> GitHub Gist script. ⭐ ALTERNATIVE METHOD⭐ Since the above approach can take over two days to process, we have developed an alternative solution that downloads the <a><code>mesh2021.nt</code></a> data file directly from MeSH and the <a><code>Flat_file_tab_delimited/names.tsv.gz</code></a> file directly from ChEBI. Using these files, we have recapitulated the <a href="https://www.bioontology.org/wiki/BioPortal_Mappings"><code>LOOM</code></a> algorithm implemented by BioPortal when creating mappings between these resources. The procedure is relatively straightforward and utilizes the following information from each resource: <ul> <li>For all MeSH <code>SCR Chemicals</code>, obtain the following information: <ul> <li>Identifiers: MeSH identifiers</li> <li>Labels: string labels using the <code>RDFS:label</code> object property</li> <li>Synonyms: track down all synonyms using the <code>vocab:concept</code> and <code>vocab:preferredConcept</code> object properties</li> </ul> </li> <li>For all ChEBI classes, obtain the following information: <ul> <li>Labels: string labels using the <code>RDFS:label</code> object property</li> <li>Synonyms: track down all synonyms using all <code>synonym</code> object properties</li> </ul> </li> </ul> Files <ul> <li>Generated Data: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/MESH_CHEBI_MAP.txt"><code>MESH_CHEBI_MAP.txt</code></a></li> </ul>   ClinVar Homepage: <a href="https://www.ncbi.nlm.nih.gov/clinvar/"><code>https://www.ncbi.nlm.nih.gov/clinvar/</code></a> Citation: <blockquote> Landrum MJ, Lee JM, Benson M, Brown GR, Chao C, Chitipiralla S, Gu B, Hart J, Hoffman D, Jang W, Karapetyan K. <a href="https://academic.oup.com/nar/article-abstract/46/D1/D1062/4641904">ClinVar: improving access to variant interpretations and supporting evidence</a>. Nucleic Acids Research. 2017;46(D1):D1062-7 </blockquote> Usage: ClinVar was utilized to create <code>variant-gene</code>, <code>variant-disease</code>, and <code>variant-phenotype</code> edges. The original data is filtered such that only records meeting the following criteria were included: <ul> <li> <code>Assembly</code> = "GRCh38" </li> <li> <code>ClinSigSimple</code> = <code>1</code> <ul> <li> <blockquote> 1 = at least one current record submitted with an interpretation of Likely pathogenic or Pathogenic (independent of whether that record includes assertion criteria and evidence)" </blockquote> </li> </ul> </li> <li> <code>ReviewStatus</code> in ["criteria provided, multiple submitters, no conflicts", "reviewed by expert panel", "practice guideline"] </li> </ul> Files <ul> <li> Downloaded Data <ul> <li><a href="https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/variant_summary.txt.gz"><code>variant_summary.txt.gz</code></a></li> <li><a href="https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/var_citations.txt"><code>var_citations.txt</code></a></li> <li><a href="https://ftp.ncbi.nlm.nih.gov/pub/clinvar/tab_delimited/allele_gene.txt.gz"><code>allele_gene.txt.gz</code></a></li> </ul> </li> <li> Generated Edge Data: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/CLINVAR_VARIANT_GENE_DISEASE_PHENOTYPE_EDGES.txt"><code>CLINVAR_VARIANT_GENE_DISEASE_PHENOTYPE_EDGES.txt</code></a> </li> </ul>   Comparative Toxicogenomics Database (CTD) Homepage: <a href="http://ctdbase.org/"><code>http://ctdbase.org/</code></a> Citations: <blockquote> Curated [chemical–gene interactions|chemical-go interactions|chemical–disease interactions|gene–pathway interactions] data were retrieved from the Comparative Toxicogenomics Database (CTD), MDI Biological Laboratory, Salisbury Cove, Maine, and NC State University, Raleigh, North Carolina. World Wide Web (URL: <a href="http://ctdbase.org/">http://ctdbase.org/</a>) Davis AP, Grondin CJ, Johnson RJ, Sciaky D, McMorran R, Wiegers J, Wiegers TC, Mattingly CJ. <a href="https://academic.oup.com/nar/article-abstract/47/D1/D948/5106145">The comparative toxicogenomics database: update 2019</a>. Nucleic Acids Research. 2018;47(D1):D948-54 </blockquote> Usage: Comparative Toxicogenomics Database (CTD) was utilized to create <code>chemical-disease</code>, <code>chemical-gene</code>, <code>chemical-GO biological process</code>, <code>chemical-GO cellular components</code>, <code>chemical-GO molecular functions</code>, <code>chemical-phenotype</code>, <code>chemical-protein</code>, <code>chemical-rna</code>, and <code>gene-pathway</code> edges. The original data is filtered such that only records meeting the following criteria were included: <ul> <li><code>chemical-disease</code>: <code>DirectEvidence</code> != ""</li> <li><code>chemical-gene</code>: <code>Organism</code> == "Homo sapiens", <code>GeneForms</code> == "gene", and affects not in <code>InteractionActions</code></li> <li><code>chemical-GO biological process</code>: <code>PhenotypeName</code> == "Biological Process" and <code>Interaction</code> <= "1.04e-47" (10th percentile)</li> <li><code>chemical-GO cellular components</code>: <code>PhenotypeName</code> == "Cellular Component" and <code>Interaction</code> <= "1.04e-47" (10th percentile)</li> <li><code>chemical-GO molecular functions</code>: <code>PhenotypeName</code> == "Molecular Function" and <code>Interaction</code> <= "1.04e-47" (10th percentile)</li> <li><code>chemical-phenotype</code>: <code>DirectEvidence</code> != ""</li> <li><code>chemical-protein</code>: <code>Organism</code> == "Homo sapiens", <code>GeneForms</code> == "protein", and affects not in <code>InteractionActions</code></li> <li><code>chemical-rna</code>: <code>Organism</code> == "Homo sapiens", <code>GeneForms</code> == "mRNA", and affects and activity not in <code>InteractionActions</code></li> <li><code>gene-pathway edges</code>: <code>PathwayName</code> == R-HSA-</li> </ul> Files <ul> <li>Downloaded Data <ul> <li>Chemical-Gene Relations: <a href="http://ctdbase.org/reports/CTD_chem_gene_ixns.tsv.gz"><code>CTD_chem_gene_ixns.tsv.gz</code></a></li> <li>Chemical-Disease/Phenotype Relations: <a href="http://ctdbase.org/reports/CTD_chemicals_diseases.tsv.gz"><code>CTD_chemicals_diseases.tsv.gz</code></a></li> <li>Chemical-GO Relations: <a href="http://ctdbase.org/reports/CTD_chem_go_enriched.tsv.gz"><code>CTD_chem_go_enriched.tsv.gz</code></a></li> <li>Gene-Pathway Relations: <a href="http://ctdbase.org/reports/CTD_genes_pathways.tsv.gz"><code>CTD_genes_pathways.tsv.gz</code></a></li> </ul> </li> </ul>   DisGeNET Homepage: <a href="https://www.disgenet.org/"><code>https://www.disgenet.org/</code></a> Citation: <blockquote> Gene-disease association data retrieved from DisGeNET v6.0 (<a href="http://www.disgenet.org/">http://www.disgenet.org/</a>), Integrative Biomedical Informatics Group GRIB/IMIM/UPF. [December, 2019]. Piñero J, Ramírez-Anguita JM, Saüch-Pitarch J, Ronzano F, Centeno E, Sanz F, Furlong LI. <a href="https://academic.oup.com/nar/advance-article-abstract/doi/10.1093/nar/gkz1021/5611674">The DisGeNET knowledge platform for disease genomics: 2019 update</a>. Nucleic Acids Research. 2019. </blockquote> Usage: DisGeNET was utilized to create <code>gene-disease</code>, and <code>gene-phenotype</code> edges. The original data is filtered such that only records meeting the following criteria were included: <code>EI</code> >= "1.0" (90th percentile). Additionally, data from this source was used to create mappings between different types of disease and phenotype identifiers, including: <ul> <li>OMIM, ORPHA, UMLS, ICD ➞ DOID</li> <li>OMIM, ORPHA, UMLS, ICD ➞ HPO</li> </ul> Files <ul> <li> Downloaded Data <ul> <li>Disease/Phenotype-Gene Relations: <a href="https://www.disgenet.org/static/disgenet_ap1/files/downloads/curated_gene_disease_associations.tsv.gz"><code>curated_gene_disease_associations.tsv.gz</code></a></li> <li>Disease Identifier Mapping: <a href="https://www.disgenet.org/static/disgenet_ap1/files/downloads/disease_mappings.tsv.gz"><code>disease_mappings.tsv.gz</code></a></li> </ul> </li> <li> Generated Mapping Data <ul> <li>Disease Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/PHENOTYPE_HPO_MAP.txt"><code>PHENOTPYE_HPO_MAP.txt</code></a></li> <li>Phenotype Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/DISEASE_MONDO_MAP.txt"><code>DISEASE_DOID_MAP.txt</code></a></li> </ul> </li> </ul>   Ensembl Homepage: <a href="https://uswest.ensembl.org/index.html"><code>https://uswest.ensembl.org/index.html</code></a> Citation: <blockquote> Zerbino DR, Achuthan P, Akanni W, Amode MR, Barrell D, Bhai J, Billis K, Cummins C, Gall A, Girón CG, Gil L. <a href="https://academic.oup.com/nar/article/46/D1/D754/4634002">Ensembl 2018</a>. Nucleic Acids Research. 2017;46(D1):D754-61 </blockquote> Usage: Ensembl data was utilized to create mappings between Ensembl genes, transcripts, and proteins with <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#national-center-for-biotechnology-information-gene">NCBI Gene identifiers</a>, <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#human-genome-organisation-gene-nomenclature-committee">HUGO gene symbols</a>, <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#universal-protein-resource-knowledgebase">UniProt Accession identifiers</a>, and <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#protein-ontology">Protein Ontology identifiers</a> in the knowledge graph (for additional details on the processing of these data, see <a href="https://github.com/callahantiff/PheKnowLator/blob/master/notebooks/Data_Preparation.ipynb"><code>Data_Preparation.ipynb</code></a>): <ul> <li>Ensembl Transcript IDs ➞ PRO IDs</li> <li>Gene Ensembl IDs ➞ Entrez Gene IDs</li> <li>Gene Ensembl IDs ➞ PRO IDs</li> <li>Gene Symbols ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ PRO IDs</li> <li>Protein Ensembl IDs ➞ UniProt Protein Accession</li> <li>STRING IDs ➞ PRO IDs</li> <li>UniProt Protein Accession ➞ Entrez Gene IDs</li> </ul> Files <ul> <li> Downloaded Data <ul> <li><a><code>Homo_sapiens.GRCh38.102.gtf</code></a></li> <li><a><code>Homo_sapiens.GRCh38.102.uniprot.tsv.gz</code></a></li> <li><a><code>Homo_sapiens.GRCh38.102.entrez.tsv.gz</code></a></li> </ul> </li> <li> Generated Mapping Data <ul> <li>Cleaned Ensembl Gene Set: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ensembl_identifier_data_cleaned.txt"><code>ensembl_identifier_data_cleaned.txt</code></a></li> <li>Merged Gene, RNA, Protein Map: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/Merged_gene_rna_protein_identifiers.pkl"><code>Merged_gene_rna_protein_identifiers.pkl</code></a></li> <li>Ensembl Transcript-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENSEMBL_TRANSCRIPT_PROTEIN_ONTOLOGY_MAP.txt"><code>ENSEMBL_TRANSCRIPT_PROTEIN_ONTOLOGY_MAP.txt</code></a></li> <li>Gene Symbol-Ensembl Transcript Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/GENE_SYMBOL_ENSEMBL_TRANSCRIPT_MAP.txt"><code>GENE_SYMBOL_ENSEMBL_TRANSCRIPT_MAP.txt</code></a></li> <li>Entrez Gene-Ensembl Transcript Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENTREZ_GENE_ENSEMBL_TRANSCRIPT_MAP.txt"><code>ENTREZ_GENE_ENSEMBL_TRANSCRIPT_MAP.txt</code></a></li> <li>Entrez Gene-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENTREZ_GENE_PRO_ONTOLOGY_MAP.txt"><code>ENTREZ_GENE_PRO_ONTOLOGY_MAP.txt</code></a></li> <li>Ensembl Gene-Entrez Gene Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENSEMBL_GENE_ENTREZ_GENE_MAP.txt"><code>ENSEMBL_GENE_ENTREZ_GENE_MAP.txt</code></a></li> </ul> </li> </ul>   GeneMANIA Homepage: <a href="https://genemania.org/"><code>https://genemania.org/</code></a> Citation: <blockquote> Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, Maitland A. <a href="https://academic.oup.com/nar/article-abstract/38/suppl_2/W214/1126704">The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function</a>. Nucleic Acids Research. 2010;38(suppl_2):W214-20 </blockquote> Usage: GeneMANIA was utilized to create <code>gene-gene</code> edges. Files <ul> <li>Downloaded Data: <a href="http://genemania.org/data/current/Homo_sapiens.COMBINED/COMBINED.DEFAULT_NETWORKS.BP_COMBINING.txt"><code>COMBINED.DEFAULT_NETWORKS.BP_COMBINING.txt</code></a></li> </ul>   Genotype-Tissue Expression Project (GTEx) Homepage: <a href="https://gtexportal.org/home/"><code>https://gtexportal.org/home/</code></a> Citation: <blockquote> Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B. <a href="http://www.nature.com/ng/journal/v45/n6/full/ng.2653.html">The genotype-tissue expression (GTEx) project</a>. Nature Genetics. 2013;45(6):580 </blockquote> Usage: The Genotype-Tissue Expression (GTEx) Project was utilized to create edges between <code>protein-cell</code>, <code>protein-anatomy</code>, <code>rna-cell</code> and <code>rna-anatomy</code> entities. The original data were filtered such that only those edges where the median TPM was >=<code>1.0</code> and genes were of any type other than protein-coding were included. It should also be noted that we chose to use the RNASeQC file over the RSEM file as advised by the GTEx website. <blockquote> The RSEM estimates are based on combining isoform-level estimates, which adds uncertainty to the resulting gene-level values (the isoform-level estimates are highly inaccurate in some cases). </blockquote> The file contains <code>54</code> unique tissue and/or cell types. GTEx provides mappings from tissue types to UBERON and EFO. These provided <a href="https://gtexportal.org/home/samplingSitePage">mappings</a> were verified and extended, such that all samples which referenced a cell type were also mapped to the Cell and the Cell Line ontologies. This resulted in a total of <code>56</code> mappings (<code>1.04</code> mappings/concepts). Files <ul> <li> Downloaded Data: <a href="https://storage.googleapis.com/gtex_analysis_v8/rna_seq_data/GTEx_Analysis_2017-06-05_v8_RNASeQCv1.1.9_gene_median_tpm.gct.gz"><code>GTEx_Analysis_2017-06-05_v8_RNASeQCv1.1.9_gene_median_tpm.gct</code></a> </li> <li> Mapping Results: <a href="https://storage.googleapis.com/pheknowlator/curated_data/zooma_tissue_cell_mapping_04JAN2020.xlsx"><code>zooma_tissue_cell_mapping_04JAN2020.xlsx</code></a> </li> <li> Generated Data The final mapping set was combined with terms from the <a href="https://www.proteinatlas.org/">Human Protein Atlas</a>, see <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources/t#human-protein-atlas">here</a> for more information. <ul> <li>All HPA tissue and cell type strings: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/HPA_tissues.txt"><code>HPA_tissues.txt</code></a></li> <li>Final Term Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/HPA_GTEx_TISSUE_CELL_MAP.txt"><code>HPA_GTEx_TISSUE_CELL_MAP.txt</code></a></li> <li>Final RNA, Gene, Protein-Tissues and Cell Types Relations: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/HPA_GTEX_RNA_GENE_PROTEIN_EDGES.txt"><code>HPA_GTEX_RNA_GENE_PROTEIN_EDGES.txt</code></a></li> </ul> </li> </ul>   Human Genome Organisation Gene Nomenclature Committee (HUGO) Homepage: <a href="https://www.genenames.org/"><code>https://www.genenames.org/</code></a> Citations: <blockquote> HGNC Database, HUGO Gene Nomenclature Committee (HGNC), European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom <a href="https://www.genenames.org/">www.genenames.org</a> Yates B, Braschi B, Gray K, Seal R, Tweedie S, Bruford E. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210531/">Genenames.org: the HGNC and VGNC Resources in 2017</a>. Nucleic Acids Research. 2017;45(D1):D619-625 </blockquote> Usage: The Human Genome Organisation (HUGO) data was utilized to obtain mappings between <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#national-center-for-biotechnology-information-gene">NCBI Gene identifiers</a>, HUGO gene symbols, <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#universal-protein-resource-knowledgebase">UniProt Accession identifiers</a>, and <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#protein-ontology">Protein Ontology identifiers</a>. For additional details on the processing of these data, see <a href="https://github.com/callahantiff/PheKnowLator/blob/master/notebooks/Data_Preparation.ipynb"><code>Data_Preparation.ipynb</code></a>: <ul> <li>Ensembl Transcript IDs ➞ PRO IDs</li> <li>Gene Ensembl IDs ➞ Entrez Gene IDs</li> <li>Gene Ensembl IDs ➞ PRO IDs</li> <li>Gene Symbols ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ PRO IDs</li> <li>Protein Ensembl IDs ➞ UniProt Protein Accession</li> <li>STRING IDs ➞ PRO IDs</li> <li>UniProt Protein Accession ➞ Entrez Gene IDs</li> </ul> Files <ul> <li> Downloaded Data: <a href="http://ftp.ebi.ac.uk/pub/databases/genenames/hgnc/tsv/hgnc_complete_set.txt"><code>hgnc_complete_set.txt</code></a> </li> <li> Generated Data <ul> <li>Merged Gene, RNA, Protein Map: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/Merged_gene_rna_protein_identifiers.pkl"><code>Merged_gene_rna_protein_identifiers.pkl</code></a></li> <li>Gene Symbol-Ensembl Transcript Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/GENE_SYMBOL_ENSEMBL_TRANSCRIPT_MAP.txt"><code>GENE_SYMBOL_ENSEMBL_TRANSCRIPT_MAP.txt</code></a></li> </ul> </li> </ul>   Human Protein Atlas (HPA) Homepage: <a href="https://www.proteinatlas.org/"><code>https://www.proteinatlas.org/</code></a> Citation: <blockquote> Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I. <a href="https://science.sciencemag.org/content/347/6220/1260419.short">Tissue-based map of the human proteome</a>. Science. 2015;347(6220):1260419 </blockquote> Usage: The Human Protein Atlas (HPA) was utilized to create <code>rna-cell</code>, <code>rna-anatomy</code>, <code>protein-cell</code>, and <code>protein-anatomy</code> edges. Evidence between gene and RNA expression in specific tissue types was derived by HPA, such that the <a href="https://www.proteinatlas.org/about/assays+annotation#normalization_rna">consensus normalized expression</a> was >=<code>1.0</code>. Zooma was utilized to automatically annotate the <code>153</code> unique tissues and cell types from Human Protein Atlas for all human protein-coding genes in the <a href="https://www.proteinatlas.org/humanproteome">Human Proteome</a> to the Cell Ontology, Cell Line Ontology, and the Uber-Anatomy Ontology. To best represent each concept, the automatic mappings from Zooma were extend through manual mapping efforts to ensure each concept cell type was matched to a Cell Ontology, Cell Line Ontology, and UBERON ontology term. This resulted in a total of <code>281</code> mappings (<code>1.84</code> mappings/concepts). Files <ul> <li> Downloaded Data: <a href="https://www.proteinatlas.org/api/search_download.php?search=&columns=g,eg,up,pe,rnatsm,rnaclsm,rnacasm,rnabrsm,rnabcsm,rnablsm,scl,t_RNA_adipose_tissue,t_RNA_adrenal_gland,t_RNA_amygdala,t_RNA_appendix,t_RNA_basal_ganglia,t_RNA_bone_marrow,t_RNA_breast,t_RNA_cerebellum,t_RNA_cerebral_cortex,t_RNA_cervix,_uterine,t_RNA_colon,t_RNA_corpus_callosum,t_RNA_ductus_deferens,t_RNA_duodenum,t_RNA_endometrium_1,t_RNA_epididymis,t_RNA_esophagus,t_RNA_fallopian_tube,t_RNA_gallbladder,t_RNA_heart_muscle,t_RNA_hippocampal_formation,t_RNA_hypothalamus,t_RNA_kidney,t_RNA_liver,t_RNA_lung,t_RNA_lymph_node,t_RNA_midbrain,t_RNA_olfactory_region,t_RNA_ovary,t_RNA_pancreas,t_RNA_parathyroid_gland,t_RNA_pituitary_gland,t_RNA_placenta,t_RNA_pons_and_medulla,t_RNA_prostate,t_RNA_rectum,t_RNA_retina,t_RNA_salivary_gland,t_RNA_seminal_vesicle,t_RNA_skeletal_muscle,t_RNA_skin_1,t_RNA_small_intestine,t_RNA_smooth_muscle,t_RNA_spinal_cord,t_RNA_spleen,t_RNA_stomach_1,t_RNA_testis,t_RNA_thalamus,t_RNA_thymus,t_RNA_thyroid_gland,t_RNA_tongue,t_RNA_tonsil,t_RNA_urinary_bladder,t_RNA_vagina,t_RNA_B-cells,t_RNA_dendritic_cells,t_RNA_granulocytes,t_RNA_monocytes,t_RNA_NK-cells,t_RNA_T-cells,t_RNA_total_PBMC,cell_RNA_A-431,cell_RNA_A549,cell_RNA_AF22,cell_RNA_AN3-CA,cell_RNA_ASC_diff,cell_RNA_ASC_TERT1,cell_RNA_BEWO,cell_RNA_BJ,cell_RNA_BJ_hTERT+,cell_RNA_BJ_hTERT+_SV40_Large_T+,cell_RNA_BJ_hTERT+_SV40_Large_T+_RasG12V,cell_RNA_CACO-2,cell_RNA_CAPAN-2,cell_RNA_Daudi,cell_RNA_EFO-21,cell_RNA_fHDF/TERT166,cell_RNA_HaCaT,cell_RNA_HAP1,cell_RNA_HBEC3-KT,cell_RNA_HBF_TERT88,cell_RNA_HDLM-2,cell_RNA_HEK_293,cell_RNA_HEL,cell_RNA_HeLa,cell_RNA_Hep_G2,cell_RNA_HHSteC,cell_RNA_HL-60,cell_RNA_HMC-1,cell_RNA_HSkMC,cell_RNA_hTCEpi,cell_RNA_hTEC/SVTERT24-B,cell_RNA_hTERT-HME1,cell_RNA_HUVEC_TERT2,cell_RNA_K-562,cell_RNA_Karpas-707,cell_RNA_LHCN-M2,cell_RNA_MCF7,cell_RNA_MOLT-4,cell_RNA_NB-4,cell_RNA_NTERA-2,cell_RNA_PC-3,cell_RNA_REH,cell_RNA_RH-30,cell_RNA_RPMI-8226,cell_RNA_RPTEC_TERT1,cell_RNA_RT4,cell_RNA_SCLC-21H,cell_RNA_SH-SY5Y,cell_RNA_SiHa,cell_RNA_SK-BR-3,cell_RNA_SK-MEL-30,cell_RNA_T-47d,cell_RNA_THP-1,cell_RNA_TIME,cell_RNA_U-138_MG,cell_RNA_U-2_OS,cell_RNA_U-2197,cell_RNA_U-251_MG,cell_RNA_U-266/70,cell_RNA_U-266/84,cell_RNA_U-698,cell_RNA_U-87_MG,cell_RNA_U-937,cell_RNA_WM-115,blood_RNA_basophil,blood_RNA_classical_monocyte,blood_RNA_eosinophil,blood_RNA_gdT-cell,blood_RNA_intermediate_monocyte,blood_RNA_MAIT_T-cell,blood_RNA_memory_B-cell,blood_RNA_memory_CD4_T-cell,blood_RNA_memory_CD8_T-cell,blood_RNA_myeloid_DC,blood_RNA_naive_B-cell,blood_RNA_naive_CD4_T-cell,blood_RNA_naive_CD8_T-cell,blood_RNA_neutrophil,blood_RNA_NK-cell,blood_RNA_non-classical_monocyte,blood_RNA_plasmacytoid_DC,blood_RNA_T-reg,blood_RNA_total_PBMC,brain_RNA_amygdala,brain_RNA_basal_ganglia,brain_RNA_cerebellum,brain_RNA_cerebral_cortex,brain_RNA_hippocampal_formation,brain_RNA_hypothalamus,brain_RNA_midbrain,brain_RNA_olfactory_region,brain_RNA_pons_and_medulla,brain_RNA_thalamus&format=tsv"><code>proteinatlas_search.tsv</code></a> </li> <li> Mapping Results: <a href="https://storage.googleapis.com/pheknowlator/curated_data/zooma_tissue_cell_mapping_04JAN2020.xlsx"><code>zooma_tissue_cell_mapping_04JAN2020.xlsx</code></a> </li> <li> Generated Data <ul> <li>Final Term Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/HPA_GTEx_TISSUE_CELL_MAP.txt"><code>HPA_GTEx_TISSUE_CELL_MAP.txt</code></a></li> <li>Final RNA, Gene, Protein-Tissues and Cell Types Relations: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/HPA_GTEX_RNA_GENE_PROTEIN_EDGES.txt"><code>HPA_GTEX_RNA_GENE_PROTEIN_EDGES.txt</code></a></li> </ul> </li> </ul>   National Center for Biotechnology Information (NCBI) Entrez Gene Homepage: <a href="https://www.ncbi.nlm.nih.gov/gene/"><code>https://www.ncbi.nlm.nih.gov/gene/</code></a> Citation: <blockquote> Maglott D, Ostell J, Pruitt KD, Tatusova T. <a href="https://academic.oup.com/nar/article-abstract/33/suppl_1/D54/2505255">Entrez Gene: gene-centered information at NCBI</a>. Nucleic Acids Research. 2005;33(suppl_1):D54-8. </blockquote> Usage: The National Center for Biotechnology Information (NCBI) Gene data was utilized to obtain mappings between <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#ncbi-gene">NCBI Gene identifiers</a>, <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#hugo-gene-nomenclature-committee">HUGO gene symbols</a>, <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#uniprot-knowledgebase">UniProt Accession identifiers</a>, and <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#protein-ontology">Protein Ontology identifiers</a>. For additional details on the processing of these data, see <a href="https://github.com/callahantiff/PheKnowLator/blob/master/notebooks/Data_Preparation.ipynb"><code>Data_Preparation.ipynb</code></a>: <ul> <li>Ensembl Transcript IDs ➞ PRO IDs</li> <li>Gene Ensembl IDs ➞ Entrez Gene IDs</li> <li>Gene Ensembl IDs ➞ PRO IDs</li> <li>Gene Symbols ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ PRO IDs</li> <li>Protein Ensembl IDs ➞ UniProt Protein Accession</li> <li>STRING IDs ➞ PRO IDs</li> <li>UniProt Protein Accession ➞ Entrez Gene IDs</li> </ul> Files <ul> <li> Downloaded Data: <a href="https://ftp.ncbi.nih.gov/gene/DATA/GENE_INFO/Mammalia/Homo_sapiens.gene_info.gz"><code>Homo_sapiens.gene_info.gz</code></a> </li> <li> Generated Data <ul> <li>Merged Gene, RNA, Protein Map: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/Merged_gene_rna_protein_identifiers.pkl"><code>Merged_gene_rna_protein_identifiers.pkl</code></a></li> <li>Entrez Gene-Ensembl Transcript Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENTREZ_GENE_ENSEMBL_TRANSCRIPT_MAP.txt"><code>ENTREZ_GENE_ENSEMBL_TRANSCRIPT_MAP.txt</code></a></li> <li>Entrez Gene-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENTREZ_GENE_PRO_ONTOLOGY_MAP.txt"><code>ENTREZ_GENE_PRO_ONTOLOGY_MAP.txt</code></a></li> <li>Ensembl Gene-Entrez Gene Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/ENSEMBL_GENE_ENTREZ_GENE_MAP.txt"><code>ENSEMBL_GENE_ENTREZ_GENE_MAP.txt</code></a></li> <li>Uniprot Accession-Entrez Gene Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/UNIPROT_ACCESSION_ENTREZ_GENE_MAP.txt"><code>UNIPROT_ACCESSION_ENTREZ_GENE_MAP.txt</code></a></li> </ul> </li> </ul>   Reactome Pathway Database Homepage: <a href="https://reactome.org/"><code>https://reactome.org/</code></a> Citation: <blockquote> Fabregat A, Jupe S, Matthews L, Sidiropoulos K, Gillespie M, Garapati P, Haw R, Jassal B, Korninger F, May B, Milacic M. <a href="https://academic.oup.com/nar/article-abstract/46/D1/D649/4626770">The reactome pathway knowledgebase</a>. Nucleic Acids Research. 2017;46(D1):D649-55 </blockquote> Usage: The Reactome Database was utilized to create <code>chemical-pathway</code>, <code>GO Biological process-pathway</code>, <code>pathway-GO Cellular component</code>, <code>GO Molecular function-pathway</code>, and <code>protein-pathway</code> edges. The original data is filtered such that only records meeting the following criteria were included: <ul> <li><code>chemical-pathway</code>: column[5] == "Homo sapiens"</li> <li><code>GO Biological process-pathway</code>: column[5] startswith "REACTOME", column[8] == "P", and column[12] == "taxon:9606"</li> <li><code>pathway-GO Cellular component</code>: column[5] startswith "REACTOME", column[8] == "C", and column[12] == "taxon:9606"</li> <li><code>GO Molecular function-pathway</code>: column[5] startswith "REACTOME", column[8] == "F", and column[12] == "taxon:9606"</li> <li><code>protein-pathway</code>: column[5] == "Homo sapiens"</li> </ul> Files <ul> <li>Downloaded Data <ul> <li>Chemical-Pathway Relations: <a href="https://reactome.org/download/current/ChEBI2Reactome_All_Levels.txt"><code>ChEBI2Reactome_All_Levels.txt</code></a></li> <li>Pathway-GO Relations: <a href="https://reactome.org/download/current/gene_association.reactome"><code>gene_association.reactome</code></a></li> <li>Protein-Pathway Relations: <a href="https://reactome.org/download/current/UniProt2Reactome_All_Levels.txt"><code>UniProt2Reactome_All_Levels.txt</code></a></li> </ul> </li> </ul>   Search Tool for Recurring Instances of Neighbouring Genes (STRING) Database Homepage: <a href="https://string-db.org/"><code>string-db.org</code></a> Citation: <blockquote> Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, Jensen LJ. <a href="https://academic.oup.com/nar/article-abstract/47/D1/D607/5198476">STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets</a>. Nucleic Acids Research. 2018;47(D1):D607-13 </blockquote> Usage: The Search Tool for Recurring Instances of Neighbouring Genes (STRING) Database was utilized to create <code>protein-protein</code> edges. The original data is filtered such that only records meeting the following criteria were included: <code>combined_score</code> >= "700" (>90th percentile). Files <ul> <li> Downloaded Data: <a href="https://stringdb-static.org/download/protein.links.v11.0/9606.protein.links.v11.0.txt.gz"><code>9606.protein.links.v11.0.txt.gz</code></a> </li> <li> Generated Data: STRING-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/STRING_PRO_ONTOLOGY_MAP.txt"><code>STRING_PRO_ONTOLOGY_MAP.txt</code></a> </li> </ul>   Universal Protein Resource (UniProt) Knowledgebase Homepage: <a href="https://www.uniprot.org/"><code>https://www.uniprot.org/</code></a> Citation: <blockquote> UniProt Consortium. <a href="https://academic.oup.com/nar/article-abstract/47/D1/D506/5160987">UniProt: a worldwide hub of protein knowledge</a>. Nucleic acids research. 2018;47(D1):D506-15 </blockquote> Usage: The Universal Protein Resource (UniProt) Knowledgebase was utilized to obtain <code>cofactor</code>/<code>catalyst</code>-<code>protein</code> and <code>protein-coding gene</code>-<code>protein</code> edges as well as mappings between <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#national-center-for-biotechnology-information-gene">NCBI Gene identifiers</a>, <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#human-genome-organisation-gene-nomenclature-committee">HUGO gene symbols</a>, <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#universal-protein-resource-knowledgebase">Universal Protein Resource (UniProt) Accession identifiers</a>, and <a href="https://github.com/callahantiff/PheKnowLator/wiki/v2-Data-Sources#protein-ontology">Protein Ontology identifiers</a>. For additional details on the processing of these data, see <a href="https://github.com/callahantiff/PheKnowLator/blob/master/notebooks/Data_Preparation.ipynb"><code>Data_Preparation.ipynb</code></a>: <ul> <li>Ensembl Transcript IDs ➞ PRO IDs</li> <li>Gene Ensembl IDs ➞ Entrez Gene IDs</li> <li>Gene Ensembl IDs ➞ PRO IDs</li> <li>Gene Symbols ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ Transcript Ensembl IDs</li> <li>Entrez Gene IDs ➞ PRO IDs</li> <li>Protein Ensembl IDs ➞ UniProt Protein Accession</li> <li>STRING IDs ➞ PRO IDs</li> <li>UniProt Protein Accession ➞ Entrez Gene IDs</li> </ul> Files <ul> <li> Downloaded Data <ul> <li>Cofactor and Catalyst relations: <a href="https://www.uniprot.org/uniprot/?query=&fil=organism%3A%22Homo%20sapiens%20(Human)%20%5B9606%5D%22&columns=id%2Centry%20name%2Creviewed%2Cdatabase(PRO)%2Cchebi(Cofactor)%2Cchebi(Catalytic%20activity)"><code>Cofactor/Catalyst Query Results</code></a></li> <li>UniProt Identifier Mapping: <a href="https://www.uniprot.org/uniprot/?query=&fil=organism%3A%22Homo%20sapiens%20(Human)%20%5B9606%5D%22&columns=id%2Cdatabase(GeneID)%2Cdatabase(Ensembl)%2Cdatabase(HGNC)%2Cgenes(PREFERRED)%2Cgenes(ALTERNATIVE)"><code>UniProt Identifier Query Results</code></a></li> </ul> </li> <li> Generated Data <ul> <li>Merged Gene, RNA, Protein Map: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/Merged_gene_rna_protein_identifiers.pkl"><code>Merged_gene_rna_protein_identifiers.pkl</code></a></li> <li>Protein-Cofactor Relations: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/UNIPROT_PROTEIN_COFACTOR.txt"><code>UNIPROT_PROTEIN_COFACTOR.txt</code></a></li> <li>Protein-Catalyst Relations: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/UNIPROT_PROTEIN_CATALYST.txt"><code>UNIPROT_PROTEIN_CATALYST.txt</code></a></li> <li>UniProt Accession-PRO Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/UNIPROT_ACCESSION_PRO_ONTOLOGY_MAP.txt"><code>UNIPROT_ACCESSION_PRO_ONTOLOGY_MAP.txt</code></a></li> <li>UniProt Accession-Entrez Gene Identifier Mapping: <a href="https://storage.googleapis.com/pheknowlator/current_build/data/processed_data/UNIPROT_ACCESSION_ENTREZ_GENE_MAP.txt"><code>UNIPROT_ACCESSION_ENTREZ_GENE_MAP.txt</code></a></li> </ul> </li> </ul>   This project is licensed under Apache License 2.0 - see the <a href="https://github.com/callahantiff/PheKnowLator/blob/master/LICENSE"><code>LICENSE.md</code></a> file for details. If you intend to use any of the information on this Wiki, please provide the appropriate attribution by citing this repository: <pre><code>@misc{callahan_tj_2019_3401437, author = {Callahan, TJ}, title = {PheKnowLator}, month = mar, year = 2019, doi = {10.5281/zenodo.3401437}, url = {https://doi.org/10.5281/zenodo.3401437} }</code></pre>

opencc-by-4.0Jun 2022View details →

Overview of the PheKnowLator Ecosystem

This figure provides an overview of the (Phenotype Knowledge TransLator) Ecosystem. The Ecosystem consists of three components as indicated by the three gray boxes: (1) Knowledge Graph Construction Resources. This component consists of resources to download and process a wide variety of heterogeneous data sources and an algorithm to customize the construction of large-scale biomedical knowledge graphs; (2) Knowledge Graph Benchmarks. This component consists of benchmarks that can be used to assess knowledge graph construction and data source decisions, compare against existing knowledge graphs, and evaluate downstream analyses, workflows, and learning algorithms; (3) Knowledge Graph Tools. This component consists of tools to use knowledge graphs, which include Jupyter Notebook-based use cases and tutorials, cloud-based storage, APIs, and triplestores. Acronyms: NT (N-Triples file format); OWL (Web Ontology Language); PKL (Python pickle file format); SPARQL (SPARQL Protocol and RDF Query Language).

opencc-by-4.0Feb 2021View details →

PheKnowLator Human Disease Knowledge Graph Benchmarks -- v1.0.0

PKT Human Disease Knowledge Graph Benchmark Builds (v1.0.0)Build Date: September 03, 2019The KG Benchmark Builds can also be downloaded from Zenodo: 👉 KGs: <a href="https://doi.org/10.5281/zenodo.7030200">https://doi.org/10.5281/zenodo.7030200</a> 👉 Embeddings: <a href="https://zenodo.org/record/7030189">https://zenodo.org/record/7030189</a> Required Input Documents<ul><li>resource_info.txt</li><li>class_source_list.txt</li><li>instance_source_list.txt</li><li>ontology_source_list.txt</li></ul> DataData Download Date: November 30, 2018Ontologies<ul><li><a href="http://purl.obolibrary.org/obo/go.owl">Gene Ontology</a></li><li><a href="http://purl.obolibrary.org/obo/hp.owl">Human Phenotype Ontology</a></li></ul>Classes<ul><li><a href="http://purl.obolibrary.org/obo/doid.owl">Human Disease Ontology</a></li><li><a href="http://geneontology.org/gene-associations/goa_human.gaf.gz">Gene Ontology: gene associations</a></li><li><a href="https://reactome.org/download/current/gene_association.reactome">Reactome: gene associations</a></li><li><a href="http://compbio.charite.de/jenkins/job/hpo.annotations.monthly/lastStableBuild/artifact/annotation/ALL_SOURCES_ALL_FREQUENCIES_genes_to_phenotype.txt">Human Phenotype Ontology: all source annotations - genes to phenotypes</a></li><li><a href="http://compbio.charite.de/jenkins/job/hpo.annotations.monthly/lastSt">Human Phenotype Ontology: all source annotations - diseases to genes to phenotypes</a></li></ul>Instances<ul><li><a href="http://ctdbase.org/reports/CTD_chem_gene_ixns.tsv.gz">CTD: chemicals-genes</a></li><li><a href="http://ctdbase.org/reports/CTD_chem_pathways_enriched.tsv.gz">CTD: chemicals-pathways</a></li><li><a href="http://ctdbase.org/reports/CTD_chemicals_diseases.tsv.gz">CTD: chemicals-diseases</a></li><li><a href="http://ctdbase.org/reports/CTD_genes_pathways.tsv.gz">CTD: genes-pathways</a></li><li><a href="http://ctdbase.org/reports/CTD_diseases_pathways.tsv.gz">CTD: diseases-pathways</a></li><li><a href="https://stringdb-static.org/download/protein.links.v10.5/9606.protein.links.v10.5.txt.gz">STRING DB: Proteins</a></li><li><a href="https://string-db.org/mapping_files/entrez_mappings/entrez_gene_id.vs.string.v10.28042015.tsv">String DB: entrez gene mappings</a></li></ul> Knowledge GraphsKnowledge Representation We worked with a PhD-level biologist to develop a knowledge representation (see the figure below) that modeled mechanisms underlying human disease. To do this, we manually mapped all possible combinations of the following six node types:<ul><li>Humans Diseases</li><li>Human Phenotypes</li><li>Human Genes</li><li>Gene Ontology concepts</li><li>Reactome Pathways</li><li>Chemicals</li></ul>As shown in the figure above, the <a href="http://basic-formal-ontology.org/">Basic Formal Ontology</a> and <a href="https://github.com/oborel/obo-relations/">Relation Ontology</a> ontologies were then used to create edges between the node types. As shown in this figure, the following edge-types were created:<ul><li>Phenotypes-Genes: The <a href="http://purl.obolibrary.org/obo/hp.owl">Human Phenotype Ontology (HP)</a> provides <a href="http://compbio.charite.de/jenkins/job/hpo.annotations.monthly/lastStableBuild/artifact/annotation/ALL_SOURCES_ALL_FREQUENCIES_genes_to_phenotype.txt">phenotype-Entrez gene annotations</a> that were used to map 6,651 HP classes to 120,288 Entrez genes.</li><li>Phenotypes-Diseases: The <a href="http://purl.obolibrary.org/obo/hp.owl">HP</a> provides <a href="http://compbio.charite.de/jenkins/job/hpo.annotations.monthly/lastStableBuild/artifact/annotation/ALL_SOURCES_ALL_FREQUENCIES_diseases_to_genes_to_phenotypes.txt">HP-DOID-Gene annotations</a> that were used to map 5,438 HP concepts to 43,817 DOID concepts.</li><li>Biological processes, Molecular Functions, and Cellular Locations-Genes: The <a href="http://purl.obolibrary.org/obo/go.owl">Gene Ontology (GO)</a> provides <a href="http://geneontology.org/gene-associations/goa_human.gaf.gz">GO-Gene annotations</a> that were used to map 17,505 GO concepts to 265,002 Entrez genes.</li><li>Biological processes, Molecular Functions, and Cellular Locations-Pathways-Pathways: <a href="https://reactome.org/">Reactome</a> provides <a href="https://reactome.org/download/current/gene_association.reactome">GO-Gene links</a> that were used to map 17,906 pathways to 1,910 biological processes, molecular functions, and cellular locations.</li><li>Chemicals-Pathways: The <a href="http://ctdbase.org/">Comparative Toxicogenomics Database (CTD)</a> provides <a href="http://ctdbase.org/reports/CTD_chem_pathways_enriched.tsv.gz">Chemical-pathway links</a> that were used to map 8,886 MESH concepts to 711,043 Reactome pathways.</li><li>Chemicals-Genes: The <a href="http://ctdbase.org/">Comparative Toxicogenomics Database (CTD)</a> provides <a href="http://ctdbase.org/reports/CTD_chem_gene_ixns.tsv.gz">Chemical-Gene links</a> that were used to map 8,881 MESH concepts 410,379 Entrez genes.</li><li>Chemicals-Diseases: The <a href="http://ctdbase.org/">Comparative Toxicogenomics Database (CTD)</a> provides <a href="http://ctdbase.org/reports/CTD_chemicals_diseases.tsv.gz">Chemical-Disease links</a> that were used to map 14,238 MESH concepts 1,216,900 DOID concepts.</li><li>Genes-Genes: The<a href="https://string-db.org/">STRING Database</a> provides <a href="https://stringdb-static.org/download/protein.links.v10.5/9606.protein.links.v10.5.txt.gz">Gene-Gene links</a> that were used to create 594,100 gene-gene interactions. When generating these mappings, only the inferred protein-protein relationships considered to be high confidence were used (score of 700 or better).</li><li>Genes-Disease: Mappings between genes and diseases were retrieved from <a href="http://www.disgenet.org/web/DisGeNET/menu">DisGeNet</a> via SPARQL endpoint and used to map 6,051 Entrez genes to 20,452 DOID concepts.</li><li>Genes-Pathways: The <a href="http://ctdbase.org/">Comparative Toxicogenomics Database (CTD)</a> provides <a href="http://ctdbase.org/reports/CTD_genes_pathways.tsv.gz">Gene-Pathway links</a> that were used to map 110,370 Entrez genes to 107,029 Reactome pathways.</li><li>Pathways-Disease: The <a href="http://ctdbase.org/">Comparative Toxicogenomics Database (CTD)</a> provides <a href="http://ctdbase.org/reports/CTD_diseases_pathways.tsv.gz">Pathway-Disease links</a> that were used to map 1,818 Reactome pathways to 106,727 DOID concepts.</li></ul> Knowledge Graph The knowledge graph represented above was built using the following steps: Merge Ontologies: Merge ontologies using the <a href="https://github.com/owlcollab/owltools/wiki">OWL Tools API</a> Express New Ontology Concept Annotations: Create new ontology annotations by asserting a relation between the instance and an instance of the ontology class. For example to assert the following relations:<blockquote><a href="https://www.ncbi.nlm.nih.gov/mesh/68009020">Morphine</a> --> <a href="https://www.ebi.ac.uk/ols/ontologies/ro/properties?iri=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FRO_0002606">is substance that treats</a> --> <a href="https://hpo.jax.org/app/browse/term/HP:0002076">Migraine</a>We would need to create two axioms:<ul><li>isSubstanceThatTreats(Morphine, x1)</li><li>instanceOf(x1, Migraine)</li></ul></blockquote>While the instance of the HP class hemiplegic migraines can be treated as an anonymous node in the knowledge graph, we generate a new international resource identifier for each newly generated instance.Deductively Close Knowledge Graph: The knowledge graph is deductively closed by using the OWL 2 EL reasoner, ELK via Protégé v5.1.1. ELK is able to classify instances and supports inferences over class hierarchies and object properties. inference over disjointness, intersection, and existential quantification (ontology class hierarchies).Generate Edge List: The final step before exporting the edge list is to remove any nodes that are not biologically meaningful or would otherwise reduce the performance of machine learning algorithms and the algorithm used to generate embeddings. 🚨 AVAILABLE FILES 🚨Available KG benchmark files are zipped and listed below. For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/September-3,-2019">here</a>.

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PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWLNETS (v2.1.0 - May 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.1.0)Build Type: Instance-Inverse Relations-OWLNETSBuild Date: May 01, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-01%2C-2021">here</a>.</li></ul>

zenodo40/100

PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWLNETS (v2.1.0 - May 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.1.0)Build Type: Instance-Standard Relations-OWLNETSBuild Date: May 01, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-01%2C-2021">here</a>.</li></ul>

zenodo40/100

PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWL (v2.1.0 - May 2021)

PKT Human Disease Knowledge Graph Benchmark Builds (v2.1.0)Build Type: Instance-Standard Relations-OWLBuild Date: May 01, 2021 <h3>Important Build Information</h3>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>). 🚨 AVAILABLE FILES 🚨 <ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-01%2C-2021">here</a>.</li></ul>