Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
11
datasets available to search
ShareScore release 0.9.0
Dataset results
11 results for “Phosphatidic acid”
Data from: Heat shock factor ZmHsf17 positively regulates phosphatidic acid phosphohydrolase ZmPAH1 and enhances maize thermotolerance
Open the record for dataset details and reuse information.
Determining the Muscle Anabolic Properties of Phosphatidic Acid.
ClinicalTrials.gov study NCT03446924. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human cell culture and in zebrafish. HS1BP3 is localized to ATG16L1- and ATG9-positive autophagosome precursors and we show that HS1BP3 binds phosphatidic acid (PA) through its PX domain. Furthermore, we find the total PA content of cells to be significantly upregulated in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1 to ATG16L1-positive membranes. We propose that HS1BP3 regulates autophagy by modulating the PA content of the ATG16L1-positive autophagosome precursor membranes through PLD1 activity and localization. Our findings provide key insights into how autophagosome formation is regulated by a novel negative-feedback mechanism on membrane lipids.
Data from: HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
Open the record for dataset details and reuse information.
DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma [ATAC-Seq]
GEO Series GSE169633. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane
GEO Series GSE308521. Homo sapiens. 12 samples. Type: Other; Expression profiling by high throughput sequencing.
Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling
GEO Series GSE160861. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by high throughput sequencing.
DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma [RNA-Seq]
GEO Series GSE169631. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of Phosphatidic Acid on Strength and Hypertrophy
ClinicalTrials.gov study NCT04277364. IPD Sharing: NO. Countries: 1. Publications: 0.
DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma [ATAC-Seq]
GEO Series GSE169502. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
phosphatidic acid in gene expression-Phosphatidic acid in gene expression
GEO Series GSE35872. Arabidopsis thaliana. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.