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26 results for “Pin1”
Pin1 two-state structural ensembles of apo, FFpSPR-bound and pCDC25c-bound form
<p>Pin1 is a two-domain cell regulator that isomerizes peptidyl-prolines. The catalytic domain (PPIase) and the other ligand-binding domain (WW) sample extended and compact conformations. Ligand binding changes the equilibrium of the interdomain conformations through an interdomain allosteric mechanism. We have described ligand-specific conformational changes that occur upon binding of pCDC25c and FFpSPR. pCDC25c binding doubles the population of the extended states compared to the virtually identical populations of the apo and FFpSPR-bound forms. pCDC25c binding to the WW domain triggers conformational changes to propagate via the interdomain interface to the catalytic site, while FFpSPR binding displaces a helix in the PPIase that leads to repositioning of the PPIase catalytic loop.</p> <p>Here, we deposit the entire magnetic resonance-based CYANA structure calculation protocols of Pin1 two-state structural ensembles of apo, FFpSPR-bound and pCDC25c-bound form that allowed us to determine the coupling of intra- and interdomain structural sampling Pin1.</p>
Pin1 two-state structural ensembles of apo, FFpSPR-bound and pCDC25c-bound form
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Transcriptional changes in response to TGFB in human pancreatic stellate cells with inhibition of PIN1
GEO Series GSE299851. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Chromatin accessibility changes in response to TGFB in human pancreatic stellate cells with knockdown of PIN1
GEO Series GSE300473. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PIN1 isomerase promotes the initiation and progression of bladder cancer through SREBP2-mediated cholesterol biosynthesis pathway
GEO Series GSE262761. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Discovery and Characterization of a Potent and Selective Pin1 Inhibitor Targeted to an Active Cysteine Site
GEO Series GSE147340. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Effect of depletion of PIN1 on gene expression of breast cancer cells
GEO Series GSE232285. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional changes of serum stimulation in mouse embryonic fibroblasts due to loss of PIN1
GEO Series GSE109457. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphat
GEO Series GSE144092. Schizosaccharomyces pombe. 3 samples. Type: Expression profiling by high throughput sequencing.
Effect of chromatin accessibility due to loss of PIN1
GEO Series GSE121094. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptional changes in response to TGFB in human pancreatic stellate cells with knockdown of PIN1
GEO Series GSE299852. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Gene expression analysis of HdhQ111 mice in a Pin1 knock-out background
GEO Series GSE64478. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of mRNA levels in response to a Pin1 knock-down
GEO Series GSE41868. Homo sapiens. 2 samples. Type: Expression profiling by array.
BM-MSC-Derived Migrasomes Reverse Stroke-Induced Thymic Atrophy and Immunosuppression via Pin1 Delivery to Thymic Epithelial Cells
GEO Series GSE305141. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Selective inhibition of Pin1 with a covalent small molecule targeting its catalytic domain
GEO Series GSE84909. Homo sapiens. 10 samples. Type: Expression profiling by array.
Expression data from prostate cancer cell lines LNCap (androgen dependent) and DU145 (androgen independent), transfected with Pin1 or control siRNA
GEO Series GSE67457. Homo sapiens. 6 samples. Type: Expression profiling by array.
Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc
GEO Series GSE77482. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq profiles of pancreatic adenocarcinoma PANC-1 and osteosarcoma U2OS cells with Pin1 knocking down
GEO Series GSE224502. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis after IAA paste application on pin1 mutant inflorescence meristems
GEO Series GSE90167. Arabidopsis thaliana. 27 samples. Type: Expression profiling by high throughput sequencing.
Substrate selectivity for semisynthetic CK2 proteins with Pin1
GEO Series GSE33150. synthetic construct; Homo sapiens. 8 samples. Type: Protein profiling by protein array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.