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8 results for “Piscirickettsia salmonis”
Data from: Genomic predictions and genome-wide association study of resistance against Piscirickettsia salmonis in coho salmon (Oncorhynchus kisutch) using ddRAD sequencing
Piscirickettsia salmonis is one of the main infectious diseases affecting coho salmon (Oncorhynchus kisutch) farming, and current treatments have been ineffective for the control of this disease. Genetic improvement for P. salmonis resistance has been proposed as a feasible alternative for the control of this infectious disease in farmed fish. Genotyping by sequencing (GBS) strategies allow genotyping of hundreds of individuals with thousands of single nucleotide polymorphisms (SNPs), which can be used to perform genome wide association studies (GWAS) and predict genetic values using genome-wide information. We used double-digest restriction-site associated DNA (ddRAD) sequencing to dissect the genetic architecture of resistance against P. salmonis in a farmed coho salmon population and to identify molecular markers associated with the trait. We also evaluated genomic selection (GS) models in order to determine the potential to accelerate the genetic improvement of this trait by means of using genome-wide molecular information. A total of 764 individuals from 33 full-sib families (17 highly resistant and 16 highly susceptible) were experimentally challenged against P. salmonis and their genotypes were assayed using ddRAD sequencing. A total of 9,389 SNPs markers were identified in the population. These markers were used to test genomic selection models and compare different GWAS methodologies for resistance measured as day of death (DD) and binary survival (BIN). Genomic selection models showed higher accuracies than the traditional pedigree-based best linear unbiased prediction (PBLUP) method, for both DD and BIN. The models showed an improvement of up to 95% and 155% respectively over PBLUP. One SNP related with B-cell development was identified as a potential functional candidate associated with resistance to P. salmonis defined as DD.
Data from: Genomic predictions and genome-wide association study of resistance against Piscirickettsia salmonis in coho salmon (Oncorhynchus kisutch) using ddRAD sequencing
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Cohabitation of Piscirickettsia salmonis genogroups (LF-89 and EM-90): Synergistic effect on growth dynamics
GEO Series GSE235725. Piscirickettsia salmonis. 9 samples. Type: Expression profiling by high throughput sequencing.
Mobile-CRISPRi as a tool for genetic manipulation in the intracellular pathogen Piscirickettsia salmonis
GEO Series GSE309378. Piscirickettsia salmonis. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of Atlantic salmon (Salmo salar) parr with higher and lower pathogen loads following Piscirickettsia salmonis infection
GEO Series GSE178327. Salmo salar. 15 samples. Type: Expression profiling by array.
Susceptibilities of Atlantic salmon to Piscirickettsia salmonis
GEO Series GSE43255. Oncorhynchus mykiss; Salmo salar. 6 samples. Type: Expression profiling by array.
Differential transcriptomic profile of Piscirickettsia salmonis LF-89 and EM-90 during an in vivo spatial separation co-culture in Atlantic salmon
GEO Series GSE266847. Piscirickettsia salmonis. 6 samples. Type: Expression profiling by high throughput sequencing.
The effect of Atlantic salmon smolts quality, robustness and welfare on resistance towards a challenge with Piscirickettsia salmonis
GEO Series GSE173095. Salmo salar. 24 samples. Type: Expression profiling by array.
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