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11 results for “Plasmodium knowlesi”
DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi
<p>Malaria parasites are unusual, early-diverging protozoans with non-canonical cell cycles. They do not undergo binary fission, but divide primarily by schizogony. This is a mode of replication involving asynchronous production of multiple nuclei within the same cytoplasm, culminating in a single mass cytokinesis event. The rate and efficiency of parasite replication is fundamentally important to malarial disease, which tends to be severe in hosts with high parasite loads. Here, we have studied for the first time the dynamics of schizogony in two human malaria parasite species, <em>Plasmodium falciparum</em> and <em>Plasmodium knowlesi</em>. These differ in their cell-cycle length, the number of progeny produced and the genome composition, among other factors. Comparing them could therefore yield new information about the parameters and limitations of schizogony. We report that the dynamics of schizogony differ significantly between these two species, most strikingly in the gap phases between successive nuclear replications, which are longer in <em>P. falciparum</em> and shorter, but more heterogenous, in <em>P. knowlesi</em>. In both species, gaps become longer as schizogony progresses, whereas each period of active replication grows shorter. In both species there is also extreme variability between individual cells, with some schizonts producing many more nuclei than others, and some individual nuclei arresting their replication for many hours while adjacent nuclei continue to replicate. The efficiency of schizogony is probably influenced by a complex set of factors in both the parasite and its host cell.</p>
Molecular Diagnostic Methods for Detection of Plasmodium Knowlesi
ClinicalTrials.gov study NCT03988296. IPD Sharing: NO. Countries: 1. Publications: 8.
DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi
Open the record for dataset details and reuse information.
Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria
ClinicalTrials.gov study NCT03056391. IPD Sharing: NO. Countries: 1. Publications: 3.
Malaria Host Pathogen Center Experiment 06: Macaca mulatta infected with Plasmodium knowlesi sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric, and histo
GEO Series GSE127079. Macaca mulatta; Plasmodium knowlesi. 47 samples. Type: Expression profiling by high throughput sequencing.
Malaria Host Pathogen Center Experiment 07A and 07B - Macaca fascicularis infected with Plasmodium knowlesi to produce and integrate clinical, hematological, parasitological, omics, telemetric and his
GEO Series GSE128115. Plasmodium knowlesi; Macaca mulatta; Macaca fascicularis. 115 samples. Type: Expression profiling by high throughput sequencing.
Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures
GEO Series GSE62886. Plasmodium knowlesi. 21 samples. Type: Expression profiling by array.
Malaria Host Pathogen Interaction Center Experiment S01: Host and parasite gene transcript abundances, from cultured cells, of Macaca mulatta infected with Plasmodium knowlesi Pk1(A+), Pk1(B+)1+, Pk1(
GEO Series GSE110970. Macaca mulatta; Plasmodium knowlesi. 9 samples. Type: Expression profiling by high throughput sequencing.
De Novo Assembly of Plasmodium knowlesi Genomes From Clinical Samples Explains the Counterintuitive Intrachromosomal Organization of Variant SICAvar and kir Multiple Gene Family Members
<p>Published DOI: <a href="https://doi.org/10.3389/fgene.2022.855052">https://doi.org/10.3389/fgene.2022.855052</a></p> <p>Supporting data for the attached publication. De Novo assembled genomes of <em>Plasmodium knowlesi</em> generated using Nanopore long reads. Supporting statistical results are included. Variant call files from structural variant calls are attached for each genome. Additionally, statistical results from BUSCO, QUAST, Pomoxis and AGAT are included. Annotation files in GFF3 format including further analyses of these annotation files are attached. Scripts for post analysis are attached with scripts for data generation presented on Github repository: "Pknowlesi_denovo_genome_assembly"</p>
Malaria Host Pathogen Interaction Center Experiment 30: Pilot experiment for Macaca mulatta infected with Plasmodium knowlesi Malayan strain sporozoites to produce and integrate measures of acute prim
GEO Series GSE123495. Plasmodium knowlesi; Macaca mulatta. 63 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional signature of CD4hiCD38hi T cells from patients with Plasmodium falciparum or Plasmodium knowlesi malaria
GEO Series GSE148655. Homo sapiens. 36 samples. Type: Expression profiling by array.
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