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47 results for “Pneumocystis carinii”
Extracellular Vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions
<p><em>Pneumocystis</em> spp. are host obligate fungal pathogens that can cause severe pneumonia in mammals and rely heavily on their host for essential nutrients. The lack of a sustainable <em>in vitro</em> culture system poses challenges in understanding their metabolism and the acquisition of essential nutrients from host lungs remains unexplored.</p> <p>Transmission electron micrographs show Extracellular Vesicles (EVs) are found near <em>Pneumocystis</em>spp. within the lung. We hypothesized that EVs transport essential nutrients to the fungi during infection. To investigate this, EVs from <em>P. carinii</em>- and <em>P. murina-</em>infected rodents were biochemically and functionally characterized. These EVs contained host proteins involved in cellular, metabolic, and immune processes as well as proteins with homologs found in other fungal EV proteomes, indicating <em>Pneumocystis</em> may release EVs. Notably, EV uptake by<em> P. carinii</em> indicated their potential involvement in nutrient acquisition and indicated a possibility for using engineered EVs for efficient therapeutic delivery. However, EVs added to <em>P. carinii</em> <em>in vitro</em>, did not show increased growth or viability, implying that additional nutrients or factors are necessary to support their metabolic requirements. Exposure of macrophages to EVs increased proinflammatory cytokine levels but did not affect macrophages' ability to kill or phagocytose <em>P. carinii</em>. These findings provide vital insights into <em>P. carinii</em> and host EV interactions, yet the mechanisms underlying <em>P. carinii</em>'s survival in the lung remain uncertain. These studies are the first to isolate, characterize, and functionally assess EVs from <em>Pneumocystis</em>-infected rodents, promising to enhance our understanding of host-pathogen dynamics and therapeutic potential.</p>
Extracellular Vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions
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Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis
ClinicalTrials.gov study NCT00000816. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Study of WR 6026 in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients
ClinicalTrials.gov study NCT00000863. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZ
ClinicalTrials.gov study NCT00000727. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
ClinicalTrials.gov study NCT00001014. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
ClinicalTrials.gov study NCT00000715. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia
ClinicalTrials.gov study NCT00001003. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV Infection
ClinicalTrials.gov study NCT00000739. IPD Sharing: Not stated. Countries: 2. Publications: 2.
The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS
ClinicalTrials.gov study NCT00000717. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP
ClinicalTrials.gov study NCT00000998. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
ClinicalTrials.gov study NCT00001013. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients
ClinicalTrials.gov study NCT00000655. IPD Sharing: Not stated. Countries: 8. Publications: 1.
An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies
ClinicalTrials.gov study NCT00000714. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Pat
ClinicalTrials.gov study NCT00002055. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Who Have Had PCP Before
ClinicalTrials.gov study NCT00002291. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Two Forms of Pentamidine in HIV-Infected Children Who May Have Pneumocystis Carinii Pneumonia
ClinicalTrials.gov study NCT00000974. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Comparison of Atovaquone and Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia in HIV-Infected Patients Who Cannot Take TMP/SMX
ClinicalTrials.gov study NCT00002340. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Two Forms of Pentamidine in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
ClinicalTrials.gov study NCT00002292. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Double-Blind Study To Evaluate the Long-Term Safety and Effectiveness of 60 mg Versus 120 mg of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
ClinicalTrials.gov study NCT00002054. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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