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15 results for “Polybrominated diphenyl ether”
Figure 2 in Cell damage induced by polybrominated diphenyl ethers on Chironomus sancticaroli (Diptera: Chironomidae)
Figure 2. Micrographs of larval Chironomus sancticaroli midgut after acute exposition to PBDEs A. Region I midgut lumen belonging to control treatment (water). B. Region I midgut lumen exposed to BDE-99 at 0.5 Μg L-1 exhibiting its narrowing. C. Epithelial cells of midgut, region I, exposed to BDE 47 at 0.5 Μg L-1 showing changes in cell morphology.D Midgut cells, region II, of control treatment (water).E Midgut cells, region II, exposed to BDE-47 at 2.0 Μg L-1 showing the cytoplasm vacuolization. Bars shows the width of the lumen.gc: gastric cecum. ep: gut epithelia. lu: lumen. sv: stomodeal valve. Scale bar: 20 Μm.
Figure 3 in Cell damage induced by polybrominated diphenyl ethers on Chironomus sancticaroli (Diptera: Chironomidae)
Figure 3. Micrographs of the salivary gland of larval Chironomus sancticaroli after acute exposition to PBDEs A. Salivary gland of control treatment (water). B. Salivary gland exposed to BDE 47 at 0.5 Μg L-1 showing formation of the cytoplasm acidophilic granules. C. Salivary gland exposed to BDE 17 at 20 Μg L-1 shows formation of the cytoplasm acidophilic granules. Arrow. Scale bar: 20 Μm.
Figure 1 in Cell damage induced by polybrominated diphenyl ethers on Chironomus sancticaroli (Diptera: Chironomidae)
Figure 1. Micrographs of oenocytes and Cuenot cells ofChironomus sancticaroli larvae after PBDE exposure.A. Oenocytes of control (water).B. Oenocytes exposed to BDE-17 at 20 Μg L-1. C. Oenocytes exposed to BDE-47 at 2.0 Μg L-1. Arrows show cytoplasm vacuolization. D. Cuénot cells of control (water). E. Cuénot cells exposed to BDE 17 at 20 Μg L-1. F. Cuenot cells exposed to BDE 47 at 2.0 ug L-1. G. Cuenot cells exposed to BDE 99 at 0.5 Μg L-1. Arrows show the brush border disruption and displacement in the apex cell. tr: trophocytes, cu: cutile, cc: Cuénot cells, oe: esophagus, cg: gastric caeca. Scale bar: 20 Μm.
Data from: Polybrominated diphenyl ether (DE-71) exposure skews phenotypic sex ratio, and alters steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis
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Polybrominated diphenyl ethers in human follicular fluid dysregulate mural and cumulus granulosa cell gene expression
<p>Polybrominated diphenyl ethers (PBDEs), a major class of flame retardants incorporated into numerous consumer products, leach out into dust resulting in widespread exposure. There is evidence from <i>in vitro</i> and <i>in vivo</i> animal studies that PBDEs affect ovarian granulosa cell function and follicular development, yet human studies of their association with female infertility are inconclusive. Here, we tested the hypothesis that exposure to the PBDEs in follicular fluid is associated with dysregulation of gene expression in the mural and cumulus granulosa cells collected from women undergoing in vitro fertilization by intracytoplasmic sperm injection. The median concentration of the ∑<sub>10</sub>PBDEs detected in the follicular fluid samples (n=37) was 15.04 pg/g wet weight. RNA microarray analyses revealed that many genes were differentially expressed in mural and cumulus granulosa cells. Highest <i>vs</i>. lowest quartile exposure to the Σ<sub>10</sub>PBDEs or to two predominant PBDE congeners, BDE-47 or BDE-153, was associated with significant effects on gene expression in both cell types. Mural granulosa cells were generally more sensitive to PBDE exposure compared to cumulus cells. Overall, gene expression changes associated with BDE-47 exposure were similar to those for ∑<sub>10</sub>PBDEs but distinct from those associated with BDE-153 exposure. Interestingly, exposure to BDE-47 and ∑<sub>10</sub>PBDEs activated the expression of genes in pathways that are important in innate immunity and inflammation. To the best of our knowledge, this is the first demonstration that exposure to these environmental chemicals is associated with the dysregulation of pathways that play an essential role in ovulation.</p>
Polybrominated diphenyl ethers in human follicular fluid dysregulate mural and cumulus granulosa cell gene expression
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Data from: Molecular mechanisms of polybrominated diphenyl ethers (BDE-47, -100 and -153) in human breast cancer cells and patient-derived xenografts
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Effect of Polybrominated diphenyl ethers (PBDEs) on gene expression of MCF7 cells
GEO Series GSE111203. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
A Mixture Reflecting Polybrominated Diphenyl Ether (PBDE) Profiles Detected in Human Follicular Fluid Significantly Affects Steroidogenesis and Induces Oxidative Stress in a Human Granulosa Cell L
GEO Series GSE77963. Homo sapiens. 23 samples. Type: Expression profiling by array.
Effects of Polybrominated Diphenyl Ether (PBDE) Mixture on estrogen receptor positive (ER+) patient-derived tumor xenograft (PDX) model
GEO Series GSE119587. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Hepatic transcriptomic alterations for polybrominated diphenyl ether 47 (PBDE47) after 5-day exposure in rats
GEO Series GSE153360. Rattus norvegicus. 36 samples. Type: Expression profiling by array.
Polybrominated diphenyl ethers (PBDEs)
GEO Series GSE119588. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic responses of hornyhead turbot (Pleuronichthys verticalis) to environmentally relevant doses of polybrominated diphenyl ethers or polychlorinated biphenyls
GEO Series GSE151532. Pleuronichthys verticalis. 38 samples. Type: Expression profiling by array.
Polybrominated diphenyl ethers (PBDEs) exposure during pregnancy alters microRNA expression profile in rat placenta
GEO Series GSE169613. Rattus norvegicus. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
DNA Methylation analysis of polybrominated diphenyl ethers (PBDEs) treated hepatocellular carcinoma
GEO Series GSE73326. Mus musculus. 8 samples. Type: Methylation profiling by genome tiling array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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