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5 results for “Polymersome”
Raw research data supporting "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors "
<p>Research data supporting Rifaie-Graham et al. "Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors."Nature Chemistry. 2022. DOI:10.1038/s41557-022-01062-4.</p>
Segregated Nanocompartments Containing Therapeutic Enzymes and Imaging Compounds within DNA-Zipped Polymersome Clusters for Advanced Nanotheranostic Platform
<p>Data underlying the figures in the publication “Segregated Nanocompartments Containing Therapeutic Enzymes and Imaging Compounds within DNA-Zipped Polymersome Clusters for Advanced Nanotheranostic Platform”, published in <em>Small,</em> <strong>2020</strong>, 16, 1906492.</p> <p><a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201906492">https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201906492</a></p> <p>Table of contents:</p> <p><strong>1. Figure 2</strong>; Zip file containing the numerical data for the graphs of <em>Figure 2 (2c, 2e, 2g & 2i)</em>.</p> <p><strong>2. Figure 3</strong>; Zip file containing the numerical data for the graphs of <em>Figure 3 (3a-d)</em>.</p> <p><strong>3. Figure 4</strong>; Zip file containing the numerical data for the graphs of <em>Figure 4 (4a-d)</em>.</p> <p><strong>4. Figure 5</strong>; Zip file containing the CLSM microscopic images from four different locations of 488-633-Ncomp clusters attached to the surface (<em>Figure 5a</em>) and images of the merged DY-633 and Atto-488 channels of the four locations with colocalized regions appearing in white (<em>Figure 5b</em>).</p> <p>The dataset also includes the numerical data/images for the <em>Figures S2, S3, S5, S7, S9, S10, S11, S13, S14</em> and <em>S16-S22</em>.</p>
Synthetic molecular motor activates drug delivery from polymersomes
<p>Data sets used for manuscript figures and SI Appendix. These data does not include raw microscopy images or huge raw datasets from the instruments used. Please email the author a.guinart.planellas@rug.nl for access to these files.</p>
Artificial Melanogenesis by Confining Melanin/Polydopamine Production Inside Polymersomes
<p>Data underlying the figures in the publication “Artificial melanogenesis by confining melanin/polydopamine production inside polymersomes”, published in <em>Macromolecular Bioscience, </em><strong>2021</strong>.</p> <p>Table of contents:</p> <p><strong>1. Figure 1</strong>; Zip. archive containing the experimental data for <em>Figure 1</em>. TEM micrographs and corresponding DLS and SLS revealing the morphology and size of (A) Melanin-polymersomes (with Tyrosinase), (B) PDA-polymersomes (with Tyrosinase), (C) empty polymersomes rehydrated with PBS only, and (D) Tyrosinase-polymersomes.</p> <p><strong>2. Figure 2</strong>; Zip. archive containing the experimental data for <em>Figure 2</em>. (A) Zeta potential values showing the absence of Dopamine, L-DOPA or Tyrosinase adsorption at the surface of polymersomes. TEM micrographs of polymersome clusters formed after adding (B) L-DOPA with Tyrosinase, (C) Dopamine with Tyrosinase, (D) L-DOPA and (E) Dopamine to empty polymersomes.</p> <p><strong>3. Figure 3</strong>; Zip. archive containing the experimental data of the graphs in <em>Figure 3</em>. Melanin and PDA formation within polymersomes monitored via UV-vis spectroscopy. Absorption spectra measured at t = 0 (grey), t=12 h (cyan) and t=24 h (orange) of incubation at 37 °C of (A) Empty polymersomes, (B) Tyrosinase polymersomes, (C) L-DOPA polymersomes, (D) L-DOPA polymersomes (with Tyrosinase), (E) Dopamine polymersomes, (F) Dopamine polymersomes (with Tyrosinase).</p> <p><strong>4. Figure 4</strong>; Zip. archive containing the experimental data for <em>Figure 4</em>. Interaction of polymersome-based melanosome mimics with HaCaT cells. (A) Cell proliferation assay showing the non-toxicity of different polymersomes encapsulating dopamine and Tyrosinase (dashed purple), L-DOPA and Tyrosinase (dashed grey), dopamine (purple), L-DOPA (grey), PBS (yellow), Tyrosinase (dashed yellow) compared to control PBS without polymersomes (blue). Cells were incubated with respective polymersomes for 24 h. (B) Cell proliferation assay showing the cytotoxicity of free L-DOPA/dopamine (with and without Tyrosinase) compared to PBS. (C) Cell proliferation assay showing the cytotoxicity/cell protection effect of different kinds of polymersomes after 40 min of UV-irradiation of cells treated for 24 h with polymersomes. (D) CLSM images showing perinuclear localization of model polymersomes (encapsulating fluorescent Atto-488) in keratinocytes. Statistical significance was shown as p values < 0.02.</p> <p> </p>
Paclitaxel Polymersomes + Carboplatin + Adebelimab: Neoadjuvant Phase Ⅱ Single-Arm Study for Resectable Mucosal Melanoma
ClinicalTrials.gov study NCT07336979. IPD Sharing: NO. Countries: 1. Publications: 0.
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