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8 results for “Polyphenol compounds”
The effect of polyphenol compounds on Helicobacter pylori eradication: a systematic review with meta-analysis
<p>Objectives: Polyphenol compounds are classified as organic compounds with phenolic units exhibiting a variety of biological functions. This meta-analysis aims to assess the efficacy and safety of polyphenol compounds (curcumin, cranberry, garlic, licorice, and broccoli) in eradicating Helicobacter pylori.</p> <p>Design: Systematic review and meta-analysis.</p> <p>Data sources: These include PubMed, Embase, The Cochrane Library, Web of Science, Medline, Chinese National Knowledge Infrastructure database , Chinese Scientific Journal Database , and Wan Fang database from inception to January 2022.</p> <p>Study selection: All randomized controlled trials comparing polyphenol compounds with the placebo or used as an adjunct treatment are included in this meta-analysis.</p> <p>Data synthesis: The treatment effect for dichotomous outcomes were assessed using risk ratio, while for continuous outcomes, mean differences (MDs) both with 95% CIs, were used. Subgroup analyses were carried out for different treatment schemes and polyphenol compound species. </p> <p>Results: 12 trials were included in the meta-analysis. The total eradication rate of H.pylori in the polyphenol compounds group was higher than in the group without polyphenol compounds. Statistical significance was also observed (RR 1.19, 95% CI:1.03 to 1.38, P=0.02). The most frequent adverse effects of polyphenol compounds included diarrhea, headache, and vomiting. However, there were no differences regarding side effects between the two groups (RR 1.47, 95% CI: 0.83 to 2.58, P=0.18). In subgroup analyses, the H.pylori eradication rate regimens with polyphenols therapy was superior to that of regimens without polyphenols therapy in the polyphenols versus placebo subgroup (RR 4.23, 95% CI:1.38 to 12.95, P=0.01), polyphenols plus triple therapy versus triple therapy subgroup (RR 1.11, 95% CI: 1.01 to 1.22, P=0.03).</p> <p>Conclusion: Polyphenol compounds can improve H.pylori eradication rates. Polyphenol compounds plus standard triple therapy can significantly improve the eradication. However, no evidence of a higher incidence of side effects could be found.</p> <p>PROSPERO registration number: CRD42022307477</p>
The effect of polyphenol compounds on Helicobacter pylori eradication: a systematic review with meta-analysis
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Short-term exposure to the simple polyphenolic compound gallic acid induces neuronal hyperactivity in zebrafish larvae
<p>Zebrafish locomotor test</p> <p>Larval locomotion in zebrafish was investigated at 72 hpf using the automated analyzer DanioVision<sup>TM</sup> Observation Chamber (Noldus Information Technology). Larvae were individually exposed to 50 µg/ml GA dissolved in E3 medium. The activity was measured at three time points: 30, 60, and 180 min. The activity measured in treated and control larvae included: 1) total distance covered by each larva (total distance, in mm), 2) total time larvae spent moving (movement, in seconds), 3) mean velocity of each larva across movement measures (velocity, in mm/sec), 4) total number of rotations completed by each larva during the experiment (one rotation was counted every time larvae turned more than 180° left or right with respect to its own body axis, counted as the frequency of left and right rotations).</p> <p> </p> <p>Cadmium treatment of zebrafish larvae</p> <p>Two batches of wild-type larvae were exposed for 3 h (from 69 to 72 hpf) to 50 and 100 µM CdCl<sub>2</sub>·H<sub>2</sub>O in an E3 medium, respectively. Half of the 50 µM and half of the 100 µM treated larvae underwent the exposition to 50 µg/ml GA. The four obtained subgroups were: <em>i.</em> Cd 50 µM only treated larva; <em>ii.</em> <em>Cd 100</em> µM only treated; <em>iii</em>. Cd 50 µM exposed to GA larvae; and <em>iv</em>. 100 µM exposed to GA larvae. All the groups underwent the behavioral observations reported above. As control groups were used: one group (Control E3) consisting of larvae in E3 medium only, and a second control with larvae exposed to 50 µg/ml GA for 30 minutes only. Larval locomotion was evaluated in a 96-well plate using the automated analyzer DanioVision<sup>TM</sup> Observation Chamber (Noldus Information Technology). Each experiment was performed in triplicate.</p> <p> </p> <p>Neurotransmitter analyses</p> <p>Neur_data report the final concentration expressed as ng of neurotransmitter per larva.</p>
Figure 3 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 3 3D response surface curve showing the influences of independent variables on the TFC (A–F).
Figure 2 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 2 3D response surface curve showing the influences of independent variables on the TPC (A–F).
Figure 4 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 4 HPLC chromatogram of A. officinalis leaves extract. a Mobile phase solvent; b Solute sovent; c Extraction solvent; d Spiked sample; e Mixed standards solution; f Standard addition. (C1: Chlorogenic acid, C2: p-coumaric acid, C3: Sinapic acid, C4: Taxifolin, C5: Luteolin -7-O-glucoside, C6: Cinnamic acid).
Figure 1 from: Nguyen N-VT, Nguyen CV, Duong NT, Dai X-TT, Nguyen KT, Le C-TT (2024) Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e115528
Figure 1 Influence of methanol concentration, ratio of solid to liquid, temperature and time ultrasonic on the extration of TPC and TFC from A. officinalis leave extracts.
Effect of Yoghurts Enriched With XXS (Mixture of Natural Polyphenolic Compounds and Plant Extracts) on the Evolution of Weight in Overweight Subjects
ClinicalTrials.gov study NCT02810041. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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