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89 results for “Pravastatin”
Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development
<p>Maternal obesity has been associated with a higher risk of pregnancy-related complications in mothers and offspring; however, effective interventions have not yet been developed. We tested two common interventions, calorie restriction and pravastatin administration, during pregnancy in a rhesus macaque model with the hypothesis that these interventions would normalize metabolic dysregulation in pregnant mothers leading to an improvement in infant metabolic and cognitive/social development. A total of 19 obese mothers were assigned to either one of the two intervention groups (n=5 for calorie restriction; n=7 for pravastatin) or an obese control group (n=7) with no intervention, and maternal gestational samples and postnatal infant samples were compared with lean control mothers (n=6). Gestational calorie restriction normalized one-carbon metabolism dysregulation in obese mothers but altered energy metabolism in their offspring. Although administration of pravastatin during pregnancy tended to normalize blood cholesterol in the mothers, it potentially impacted the gut microbiome and kidney function of their offspring. In the offspring, both calorie restriction and pravastatin administration during pregnancy tended to normalize the activity of AMPK in the brain at 6 months, and while results of the Visual Paired-Comparison test, which measures infant recognition memory, were not significantly impacted by either of the interventions, gestational pravastatin administration, but not calorie restriction, tended to normalize anxiety assessed by the Human Intruder test. Although the two interventions tested in a non-human primate model led to some improvements in metabolism and/or infant brain development, negative impacts were also found in both mothers and infants. Our study emphasizes the importance of assessing gestational interventions for maternal obesity on both maternal and offspring long-term outcomes.</p>
S0919 Idarubicin, Cytarabine, and Pravastatin in Treating Patients With Relapsed Acute Myeloid Leukemia
ClinicalTrials.gov study NCT00840177. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Compare the Efficacy and Safety of Pitavastatin and Pravastatin in Elderly Patients
ClinicalTrials.gov study NCT00257686. IPD Sharing: Not stated. Countries: 5. Publications: 1.
A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria
ClinicalTrials.gov study NCT00879034. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia
ClinicalTrials.gov study NCT01082588. IPD Sharing: Not stated. Countries: 1. Publications: 68.
Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
ClinicalTrials.gov study NCT04425902. IPD Sharing: YES. Countries: 1. Publications: 1.
Prevail-Us: A Study Of Pitavastatin 4 mg Vs. Pravastatin 40 mg In Patients With Primary Hyperlipidemia Or Mixed Dyslipidemia
ClinicalTrials.gov study NCT01256476. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Pravastatin to Prevent Preeclampsia
ClinicalTrials.gov study NCT03944512. IPD Sharing: YES. Countries: 1. Publications: 1.
Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development
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Yokohama Assessment of Fluvastatin, Pravastatin, Pitavastatin and Atorvastatin in Acute Coronary Syndrome (Yokohama-ACS)
ClinicalTrials.gov study NCT00549926. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes
ClinicalTrials.gov study NCT02754739. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Effect of Pravastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT02992548. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
A 12-Week Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects
ClinicalTrials.gov study NCT01301066. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Additive Effects of Pravastatin and Valsartan
ClinicalTrials.gov study NCT01004237. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Observational Study Investigating the Effectiveness of Pravastatin on Renal Function in Korean Dyslipidemic Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT05107063. IPD Sharing: NO. Countries: 1. Publications: 1.
Pravastatin for Prevention of Preeclampsia
ClinicalTrials.gov study NCT01717586. IPD Sharing: NO. Countries: 1. Publications: 4.
Indonesia Pravastatin to Prevent Preeclampsia Study
ClinicalTrials.gov study NCT03648970. IPD Sharing: NO. Countries: 1. Publications: 21.
Sorafenib Tosylate With or Without Pravastatin in Treating Patients With Liver Cancer and Cirrhosis
ClinicalTrials.gov study NCT01075555. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Influence of Raltegravir on Pravastatin Pharmacokinetics(GRAPPA)
ClinicalTrials.gov study NCT00665717. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Rosuvastatin Versus Pravastatin in HIV Patients Treated With Boosted Protease Inhibitors (PI) (ANRS126)
ClinicalTrials.gov study NCT00117494. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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