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13 results for “Psidium guajava”
Antileishmanial compounds isolated from Psidium guajava L. using a metabolomic approach
<p>With an estimated annual incidence of 1 million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available treatments involve side effects, including toxicity, non-specific targeting, and resistance development. Thus, new antileishmanial chemical entities are of the utmost interest to fight against this disease. The aim of this study was to obtain potential antileishmanial natural products from <em>Psidium guajava</em> leaves using a metabolomic workflow. Several crude extracts from <em>P. guajava</em> leaves harvested from different locations Lao People’s Democratic Republic (Lao PDR) were profiled by liquid chromatography coupled to high-resolution mass spectrometry and evaluated for their antileishmanial activities. The putative active compounds were highlighted by multivariate correlation analysis between the antileishmanial response and chromatographic profiles of <em>P. guajava</em> mixtures. The results showed that the pooled apolar fractions from <em>P. guajava</em> were the most active (IC<sub>50</sub> = 1.96±0.47 µg/mL). Multivariate data analysis of the apolar fractions highlighted a family of triterpenoid compounds, including jacoumaric acid (IC<sub>50</sub> = 1.318±0.59 µg/mL) and corosolic acid (IC<sub>50</sub> = 1.01±0.06 µg/mL). Our approach allowed the identification of antileishmanial compounds from the crude extracts in only a small number of steps steps and can be easily adapted for use in the discovery workflows of several other natural products.</p>
Fig. 3 in Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking
Fig. 3. (A) Key 1H–1H COSY, HMBC and NOESY correlations and (B) calculated and experimental CD spectra of compounds 1, 3, 4, 6 and 8.
Fig. 1 in Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking
Fig. 1. Comparative analysis of extracts of P. guajava L. grown in Jeju Island, Vietnam and China using LC-MS/MS-based molecular networking. (A) Entire MN of all samples of three regions, (B) Psidium meroterpenoid cluster consistent with samples from Vietnam and China, (C) Target clusters of Jejuguava and isolate nodes.
Fig. 4. 3D docking simulations and 2D in Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking
Fig. 4. 3D docking simulations and 2D diagrams of ligand interactions for compounds 1–4 in the active site of PTP1B (PDB code 1NNY).
Fig. 3 in Chemical constituents of Psidium guajava leaves and their antibacterial activity
Fig. 3. Experimental CD spectra of (+)/()-1, (+)/()-2, and (+)/()-3, and calculated ECD spectra of R-3 and S-3.
In Vitro Analysis of Guava (Psidium Guajava Linn) and Papaya (Carita Papaya L.) Leaves Extract Combination Against Escherichia Coli Growth
Open the record for dataset details and reuse information.
Fig. 2 in Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking
Fig. 2. Chemical structures of compounds 1–10 isolated from the leaves of P. guajava (guava).
Fig. 5 in Chemical constituents of Psidium guajava leaves and their antibacterial activity
Fig. 5. Perspective ORTEP drawing for compound (+)-2.
Fig. 2. Key 2D in Chemical constituents of Psidium guajava leaves and their antibacterial activity
Fig. 2. Key 2D correlations of compounds 1–4.
Fig. 6. Perspective ORTEP drawing for compound 4 in Chemical constituents of Psidium guajava leaves and their antibacterial activity
Fig. 6. Perspective ORTEP drawing for compound 4.
Fig. 1 in Chemical constituents of Psidium guajava leaves and their antibacterial activity
Fig. 1. Structures of compounds 1–4.
Fig. 4 in Chemical constituents of Psidium guajava leaves and their antibacterial activity
Fig. 4. Perspective ORTEP drawings for compounds (+)-1 and ()-1.
Fig. 5 in Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking
Fig. 5. Hypotheticlal biogenetic pathway of all the isolates (1–10).
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International Brain Laboratory public data
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OpenNeuro
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