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128 results for “Purkinje”
Correlative microscopy of mice cerebellar Purkinje cells from 20x confocal tissue imaging to super-resolution 93x 3D STED of dendritic spines
<p>This Dataset concerns the paper entitled "<em>From tissues to segmentation: a modular framework for multi-scale neuron isolation</em>" by Cauzzo et al. <strong>Nature Comm (2024).</strong></p> <p>S.Cauzzo<sup>$</sup>, E. Bruno, D. Boulet, P. Nazac, M. Basile, A. L. Callara, F. Tozzi, A. Ahluwalia, C. Magliaro, L. Danglot<sup>$</sup><sup>*</sup>, N. Vanello<sup>$</sup><sup>*</sup> *shared senior authorship: Lydia.danglot@inserm.fr ; nicola.vanello@unipi.it</p> <p><sup>$</sup> corresponding authors : cauzzo.simone@gmail.com ; Lydia.danglot@inserm.fr ; nicola.vanello@unipi.it</p> <p> </p>
Raw Data for the Protocol: Antibody-Assisted Selective Isolation of Purkinje Cell Nuclei
<p>Sun1/sfGFP+, Pcp2-Cre+ and Sun1/sfGFP+, Pcp2-Cre- cryosectioned cerebella immunostained for the Myc tag (files 3037, 3046), which is fused to the GFP protein, Calbindin (files 3038, 3047) and Hoechst (files 3036, 3045). </p> <p> </p> <p>Original uncropped images from western blot analysis of TOM20, Histone H3, and GAPDH.</p>
Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human
<p>Canonically, each Purkinje cell in the adult cerebellum receives only one climbing fiber from the inferior olive. Underlying current theories of cerebellar function is the notion that this highly conserved one-to-one relationship renders Purkinje dendrites into a single computational compartment. However, we show that multiple primary dendrites are a near-universal morphological feature in humans. Using tract-tracing, immunolabeling, and in vitro electrophysiology, we demonstrate in mice that ~25% of mature polydendritic cells receive more than one climbing fiber input. Two-photon calcium imaging in vivo reveals that separate dendrites can exhibit distinct response properties to sensory stimulation, indicating some polydendritic cells integrate functionally independent climbing fiber receptive fields. These findings reveal that Purkinje cells are morphologically and functionally more diverse than previously thought.</p>
Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human
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[3/3] Patch clamp of a Purkinje cell in a simulated cerebellar cortex model during single impulse stimulation
<p>Patch clamp of a Purkinje cell in a simulated cerebellar cortex model during single impulse stimulation</p>
[2/3] Patch clamp of a Purkinje cell in a simulated cerebellar cortex model during single impulse stimulation
<p>Patch clamp of a Purkinje cell in a simulated cerebellar cortex model during single impulse stimulation</p>
[1/3] Patch clamp of a Purkinje cell in a simulated cerebellar cortex model during single impulse stimulation
<p>Patch clamp of a Purkinje cell in a simulated cerebellar cortex model during single impulse stimulation</p>
HIS-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy
ClinicalTrials.gov study NCT04561778. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Characterization of direct Purkinje cell outputs to the brainstem
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Associative plasticity of granule cell inputs to cerebellar Purkinje cells
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Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum
<p>Here we provide the data for the paper "Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum". The dataset is saved as MAT-file (version 7.0). The source code for analysis is saved in github. Folder names indicate the contents corresponding to the specific figures in the paper.</p>
Synaptic currents through Purkinje cells in response to a single impulse in the granular layer
<p>Synaptic currents through Purkinje cells in response to a single impulse in the granular layer</p>
Purkinje cell responses during diverse Granule cell plasticity scenarios
<p>Purkinje cell responses during diverse Granule cell plasticity scenarios</p>
Ionic conductances driving tonic firing in Purkinje neurons of larval zebrafish
<p>This contains all the analysed dataset related to the publication in Journal of Physiology; Jadhav et al., 2025. Folders contain data used for each figure. Scripts to analyse eletrophysiology recordings and generate figures added in a separate folder.</p>
Motor context dominates output from Purkinje cell functional regions during reflexive visuomotor behaviors
<p>Example calcium imaging dataset for Knogler et al., 2018</p>
Purkinje cell
Drawing uploaded to scidraw.io on: 16 August 2019
Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior
<p>Dataset belonging to "Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior" (https://doi.org/10.1073/pnas.2015292118)</p>
Dendritic coincidence detection in Purkinje neurons of awake mice
<p><span>Dendritic coincidence detection is thought fundamental to neuronal processing yet remains largely unexplored in awake animals. Specifically, the underlying dendritic voltage-calcium relationship has not been directly addressed. Here, using simultaneous voltage and calcium two-photon imaging of Purkinje neuron spiny dendrites, we show how coincident synaptic inputs and resulting dendritic spikes modulate dendritic calcium signaling during sensory stimulation in awake mice.<span> </span></span><span>Sensory stimulation increase</span><span>d</span><span><span> </span>the rate of post</span><span>-</span><span>synaptic potentials and dendritic calcium spikes evoked by climbing<span> </span></span><span>fiber<span> </span></span><span>and parallel fiber</span><span><span> </span>synaptic input. These inputs are integrated in a time-dependent and non-linear fashion to enhance the sensory evoked dendritic calcium signal. Intrinsic supralinear dendritic mechanisms, including voltage-gated calcium channels and metabotropic glutamate receptors, are recruited cooperatively to expand the dynamic range of sensory evoked dendritic calcium signals. This establishes how dendrites can use multiple interplaying mechanisms to perform coincidence detection, as a fundamental and ongoing feature of dendritic integration in behaving animals.</span></p>
Dendritic coincidence detection in Purkinje neurons of awake mice
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Data from: SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor learning-specific memory traces
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