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152 results for “Quorum Sensing”
Spatial structure, chemotaxis and quorum sensing shape bacterial biomass accumulation in complex porous media
<p>Dataset associated to the publication</p><p>"Spatial structure, chemotaxis and quorum sensing shape bacterial biomass accumulation in complex porous media"</p><p>By</p><p>David Scheidweiler, Ankur Deep Bordoloi, Wenqiao Jiao, Vladimir Sentchilo, Monica Bollani, Audam Chhun, Philipp Engel and Pietro de Anna</p><p>Folder named "Figure_X" contains the original raw data, analysed data and source data for each plot within figure "X" on the manuscript and supplementary information.</p><p>We do not provide raw data for each replica as one flow&growth experiment consists in 50 large images for a total of about 12 GB per dataset. Thus, we provide here the original data for the Wild Type experiment and the control D-luxS mutant. The data for the replicas and other control experiment can be available upon request.</p><p>We provide Matlab scripts to read and analyze the original images.</p>
No evidence for quorum sensing during egg hatching in the cestode <em>Schistocephalus solidus</em>
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The cost and benefit of quorum sensing controlled bacteriocin production in Lactobacillus plantarum
Bacteria eliminate competitors via 'chemical warfare' with bacteriocins. Some species appear to adjust bacteriocin production conditionally in response to the social environment. We tested whether variation in the cost and benefit of producing bacteriocins could explain such conditional behaviour, in the bacteria Lactobacillus plantarum. We found that: (1) bacterial bacteriocin production could be upregulated by either the addition of a synthetic autoinducer peptide (PLNC8IF; signalling molecule), or by a plasmid which constitutively encodes for the production of this peptide; (2) bacteriocin production is costly, leading to reduced growth when grown in poor and, to a lesser extent, in rich media; (3) bacteriocin production provides a fitness advantage, when grown in competition with sensitive strains; (4) the fitness benefits provided by bacteriocin production is greater at higher cell densities. These results show how the costs and benefits of upregulating bacteriocin production can depend upon abiotic and biotic conditions.
RASTtk annotations of Chromobacterium vaccinii MWU328 and quorum sensing mutant MWU328W
<p>RASTtk genome annotations of Chromobacterium vaccinii MWU328 (wild type) and a spontaneous frameshift mutant in the cviR (quorum sensing autoinducer receptor) gene MWU328W.</p>
Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle
<p>Sequence data linked to the manuscript "Airway environment drives the selection of quorum sensing mutants and promote <em>Staph</em><em>ylococcus</em><em> aureus</em> chronic lifestyle"</p> <p>- Shotgun metagenomic from sputa of Patients A B C H J</p> <p>- 10 hemolytic and 10 non-hemolytic isolates from competition assays at day 5</p>
RefAHL: A curated quorum sensing reference linking diverse LuxI-type signal synthases with their acyl-homoserine lactone products
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The cost and benefit of quorum sensing controlled bacteriocin production in Lactobacillus plantarum
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Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip
<p>Raw gels and microscopy images used in a study on the interaction between Qtip and its partner phage repressor protein.</p> <p> </p> <p> </p>
Data from: Quorum-sensing signaling by chironomid egg masses' microbiota affects haemagglutinin/protease (HAP) production by Vibrio cholerae
<p><i>Vibrio cholerae</i>, the causative agent of cholera, is commonly isolated, along with other bacterial species, from chironomid insects (<i>Diptera: Chironomide</i>). Nevertheless, its prevalence in the chironomid egg masses' microbiota is less than 0.5%. <i>V. cholerae</i> secretes haemagglutinin/protease (HAP) that degrades the gelatinous matrix of chironomid egg masses and prevents hatching. Quorum sensing (QS) activates HAP production in response to accumulation of bacterial autoinducers (AIs). Our aim was to define the impact of chironomid microbiota on HAP production by <i>V. cholerae</i>. To study QS signaling, we used<i> V. cholerae</i> bioluminescence reporter strains (QS-proficient O1 El-Tor wild type and QS-deficient mutants) and different bacterial species that we isolated from chironomid egg masses. These egg mass isolates, as well as a synthetic AI-2, caused an enhancement in <i>lux</i> expression by a <i>V. cholerae</i> QS-deficient mutant. The addition of the egg mass bacterial isolate supernatant to the QS-deficient mutant also enhanced HAP production and egg mass degradation activities. Moreover, the <i>V. cholerae</i> wild type strain was able to proliferate using egg masses as their sole carbon source while the QS-deficient was not. The results demonstrate that members of the chironomid bacterial consortium produce external chemical cues that, like AI-2, induce expression of the<i> hapA </i>gene in <i>V. cholerae</i>. Understanding the interactions between <i>V. cholerae</i> and the insects' microbiota may help uncover the interactions between this pathogen and the human gut microbiota.</p>
Molecular Simulations of Lipid Membrane Partitioning and Translocation by Bacterial Quorum Sensing Modulators
<p>All simulation data and analysis tools for regenerating results from the journal paper:</p> <p>T. Jin, S. J. Patel, and R. C. Van Lehn. “Molecular simulations of lipid membrane partitioning and translocation by bacterial quorum sensing modulators.” <em>PLOS ONE</em>, <strong>accepted.</strong></p>
Basic data that show effect of Panax ginseng and Symphytum officinale boost metronidazole on quorum sensing and biofilm disruption in Porphyromonas gingivalis
<p>Basic data that show effect of Panax ginseng and Symphytum officinale boost metronidazole on quorum sensing and biofilm disruption in Porphyromonas gingivalis</p>
Data from: Strain identification and quorum sensing inhibition characterization of marine-derived Rhizobium sp. NAO1
A novel strategy for combating pathogens is through the ongoing development and use of anti-quorum sensing (QS) treatments such as therapeutic bacteria or their anti-QS substances. Relatively little is known about the bacteria that inhabit the open ocean and of their potential anti-pathogenic attributes; thus, in an initiative to identify these types of therapeutic bacteria, planktonic microbes from the North Atlantic Ocean were collected, isolated, cultured and screened for anti-QS activity. Screening analysis identified one such strain, Rhizobium sp. NAO1. Extracts of Rhizobium sp. NAO1 were identified via ultra-performance liquid chromatography (UPLC) analysis. They were shown to contain N-acyl homoserine lactone (AHL)-based QS analogues (in particular, the N-butyryl homoserine lactone (C4-AHL) analogue) and could disrupt biofilm formation by Pseudomonas aeruginosa PAO1. QS inhibition was confirmed using confocal scanning laser microscopy and growth curves, and it was shown to occur in a dose-dependent manner without affecting bacterial growth. Secondary metabolites of Rhizobium sp. NAO1 inhibited PAO1 pathogenicity by downregulating AHL-mediated virulence factors such as elastase activity and siderophore production. Furthermore, as a result of biofilm structure damage, the secondary metabolite products of Rhizobium sp. NAO1 significantly increased the sensitivity of PAO1 to aminoglycoside antibiotics. Our results demonstrated that Rhizobium sp. strain NAO1 has the ability to disrupt P. aeruginosa PAO1 biofilm architecture, in addition to attenuating P. aeruginosa PAO1 virulence factor production and pathogenicity. Therefore, the newly identified ocean-derived Rhizobium sp. NAO1 has the potential to serve as a QS inhibitor and may be a new microbial resource for drug development.
5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice
<p>Data underlying the figures in the publication “5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice”, published in <em>Nucleic Acids Research</em>, <strong>2021</strong>, gkab251. <a href="https://doi.org/10.1093/nar/gkab251">https://doi.org/10.1093/nar/gkab251</a></p> <p>Table of contents:</p> <p><strong>1. Dataset</strong>; Excel file with the numerical values for figures of screen (publicly available hit compounds) and hit validation <em>in vitro</em> and <em>in vivo</em>. Dataset of <em>Figures 2, 3, 4, 5, 6</em> and <em>S2</em> & <em>S4</em>.</p>
Periodically disturbing biofilms reduces expression of quorum sensing regulated virulence factors in Pseudomonas aeruginosa
<p>The opportunistic pathogen <em>Pseudomonas aeruginosa</em> uses quorum sensing to control the expression of multiple virulence factors. In this dataset, we provide raw data demonstrating that periodically disturbing biofilms composed of <em>P. aeruginosa</em> using a physical force reduces the expression of multiple quorum sensing regulated virulence factors from the three major regulons. This dataset also contains cell density measurements of bacteria both the in biofilm and planktonic state under a variety of conditions that use physical force to manipulate the spatial positioning of bacteria. Finally, the data set contains raw outputs from a network logic model that described the core quorum sensing network. This data is affiliated with the manuscript entitled "Periodically disturbing biofilms reduces expression of quorum sensing regulated virulence factors in <em>Pseudomonas aeruginosa</em>."</p>
Studying the Distribution of Accessory Gene Regulator (Agr) Quorum Sensing System and the Prevalence of Linezolid and Mupirocin Resistance in Biofilm Producer/Non Producer Staphylococcus Aureus in Soh
ClinicalTrials.gov study NCT06291181. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Azithromycin as a Quorum-Sensing Inhibitor for the Prevention of Pseudomonas Aeruginosa Ventilator-Associated Pneumonia
ClinicalTrials.gov study NCT00610623. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Data from: Strain identification and quorum sensing inhibition characterization of marine-derived Rhizobium sp. NAO1
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Periodically disturbing biofilms reduces expression of quorum sensing regulated virulence factors in Pseudomonas aeruginosa
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Data from: Quorum-sensing signaling by chironomid egg masses’ microbiota affects haemagglutinin/protease (HAP) production by Vibrio cholerae
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Data from: Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production
Bacteria produce a wide variety of exoproducts that favourably modify their environment and increase their fitness. These are often termed 'public goods' because they are costly for individuals to produce and can be exploited by non-producers (cheats). The outcome of conflict over public goods is dependent upon the prevailing environment and the phenotype of the individuals in competition. Many bacterial species use quorum sensing (QS) signalling molecules to regulate the production of public goods. QS, therefore, determines the cooperative phenotype of individuals, and influences conflict over public goods. In addition to their regulatory functions, many QS molecules have additional properties that directly modify the prevailing environment. This leads to the possibility that QS molecules could influence conflict over public goods indirectly through non-signalling effects, and the impact of this on social competition has not previously been explored. The Pseudomonas aeruginosa QS signal molecule PQS is a powerful chelator of iron which can cause an iron starvation response. Here, we show that PQS stimulates a concentration-dependent increase in the cooperative production of iron scavenging siderophores, resulting in an increase in the relative fitness of non-producing siderophore cheats. This is likely due to an increased cost of siderophore output by producing cells and a concurrent increase in the shared benefits, which accrue to both producers and cheats. Although PQS can be a beneficial signalling molecule for P. aeruginosa, our data suggest that it can also render a siderophore-producing population vulnerable to competition from cheating strains. More generally, our results indicate that the production of one social trait can indirectly affect the costs and benefits of another social trait.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.