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ShareScore release 0.9.0
Dataset results
61 results for “RAS mutant”
Excited state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants
<p>Despite the prominent role of the K-Ras protein in many different types of human cancer, major gaps in atomic-level information severely limit our understanding of K-Ras function in health and disease. Here, we report the quantitative backbone structural dynamics of K-Ras by solution NMR spectroscopy of the active state of wild-type K-Ras·GTP and two of its oncogenic P-loop mutants, G12D and G12C, using a novel nanoparticle-assisted spin relaxation method, relaxation dispersion and chemical exchange saturation transfer experiments covering the entire range of timescales from picosecond to milliseconds. Our combined experiments allow the detection and analysis of the functionally critical Switch I and Switch II regions that have previously remained largely unobservable by X-ray crystallography and NMR spectroscopy. Our data reveal cooperative transitions of K-Ras·GTP to a highly dynamic excited state that closely resembles the partially disordered K-Ras·GDP state. These results advance our understanding of differential GTPase activities and signaling properties of the WT versus mutants and may thus guide new strategies for the development of therapeutics.</p>
Phase Ib/II Study of Efficacy and Safety of MEK162 and Panitumumab, in Adult mCRC Patients With Mutant or Wild-type RAS Tumors
ClinicalTrials.gov study NCT01927341. IPD Sharing: YES. Countries: 7. Publications: 1.
A Study of Avelumab, Binimetinib and Talazoparib in Patients With Locally Advanced or Metastatic RAS-mutant Solid Tumors
ClinicalTrials.gov study NCT03637491. IPD Sharing: NO. Countries: 3. Publications: 2.
Excited state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants
Open the record for dataset details and reuse information.
Combination With Sintilimab and XELOX+Bevacizumab as 1st Line Therapy in RAS-mutant Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT05171660. IPD Sharing: NO. Countries: 1. Publications: 1.
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Trea
ClinicalTrials.gov study NCT05554328. IPD Sharing: YES. Countries: 2. Publications: 0.
Avastin in Combination With Chemotherapy for RAS Mutant Unresectable Colorectal Liver-limited Metastases
ClinicalTrials.gov study NCT01972490. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or K-RAS Mutant Colon Cancers
ClinicalTrials.gov study NCT01149434. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cetuximab in Third Line for Mutant APC, TP53 and RAS Patients With Refractory Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT04853043. IPD Sharing: NO. Countries: 1. Publications: 0.
Injury prevents Ras mutant cell expansion in mosaic skin
GEO Series GSE195892. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [CMPs and GMPs scRNA-Seq]
GEO Series GSE254478. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic Reprogramming of mutant RAS-driven Rhabdomyosarcoma via MEK Inhibition
GEO Series GSE85171. Mus musculus; Homo sapiens. 60 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
RAS-mutant AML stem cells acquire resistance to BH3 mimetics through altered BCL-2 family expression
GEO Series GSE235206. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia
GEO Series GSE273209. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [scRNA-Seq]
GEO Series GSE275501. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [RNA-Seq]
GEO Series GSE253426. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability
GEO Series GSE24010. Mus musculus. 7 samples. Type: Expression profiling by array.
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics [scRNA-Seq]
GEO Series GSE253702. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Acquired resistance to mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling
GEO Series GSE59239. Homo sapiens. 14 samples. Type: Genome variation profiling by array.
RAS-mutant AML LSCs originate from GMPs and drive clinical resistance to BH3 mimetics
GEO Series GSE253715. Homo sapiens. 41 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.