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Dataset results
92 results for “REM sleep”
Dautan et al 2024 " Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder"
<p><span>Parkinson’s disease (PD) is characterized by progressive motor as well as less recognized non-motor symptoms that arise often years before motor manifestation, including sleep and gastrointestinal disturbances. Despite the heavy burden on the patient’s quality of life, these non-motor manifestations are poorly understood. To elucidate the temporal dynamics of the disease, we employed a mice model involving injection of alpha-synuclein (αSyn) pre-formed fibrils (PFF) in the duodenum and antrum as a gut-brain model of Parkinsonism. Using anatomical mapping of αSyn PFF propagation and behavioral and physiological characterizations, we unveil a correlation between post-injection time the temporal dynamics of αSyn propagation and non-motor/motor manifestations of the disease. We highlight the concurrent presence of aggregates in key brain regions, expressing acetylcholine or dopamine and their functions in sleep duration, wakefulness, and particularly REM-associated atonia corresponging to REM behavioral disorder-like symptoms. This study presents a novel and in-depth exploration into the multifaceted nature of PD, unraveling the complex connections between α-synucleinopathies, gut-brain connectivity, and the emergence of non-motor phenotypes.</span></p>
Closed-loop auditory stimulation targeting alpha and theta oscillations during REM sleep induces phase-dependent power and frequency changes
<p>This repository contains raw data, sleep scoring, and data to create the figures for the paper:</p> <p><strong>"Closed-loop auditory stimulation targeting alpha and theta oscillations during REM sleep induces phase-dependent power and frequency changes"</strong></p> <p>by Valeria Jaramillo, Henry Hebron, Sara Wong, Giuseppe Atzori, Ullrich Bartsch, Derk-Jan Dijk*, Ines R. Violante* (* contributed equally).</p> <p>Journal article has been published in SLEEP and can be found here: <a href="https://doi.org/10.1093/sleep/zsae193">https://doi.org/10.1093/sleep/zsae193</a></p> <p>Code can be found here: <a href="https://gitlab.surrey.ac.uk/nemo/RSN">https://gitlab.surrey.ac.uk/nemo/RSN</a></p> <p>Please cite as indicated under 'Citation' on this page.</p> <p>More information on the datafiles can be found in the README.</p>
Transparency dataset of "Noradrenergic circuit control of non-REM sleep substates"
<p>Raw transparency data file containing the information used the study “Noradrenergic circuit control of non-REM sleep substates” (Osorio-Forero, Cardis, Vantomme, Guillaume-Gentil, Katsioudi, Devenoges, Fernandez, Lüthi).</p> <p>Here you can find the raw data used for the effects of blockage of in-vivo or in-vitro noradrenergic signaling in the thalamus in sleep spindles clustering and cellular mechanisms. The effects on sleep spindles and sigma activity upon optogenetic stimulation of Locus coeruleus (LC) cells bodies, thalamic or somatosensory cortical LC terminals during non-rapid-eye movement sleep as well as the optogenetic inhibition of the LC bodies. Additionally, you can find the Information about the LC fiber density within the thalamus and somatosensory cortex. The effects on heart rate upon optogenetic stimulation of LC cell bodies is also included in the dataset. </p>
Biomarkers of neurodegeneration in isolated and antidepressant-related REM sleep behavior disorder.
<p>Dataset relative to the manuscript "Biomarkers of neurodegeneration in isolated and antidepressant-related REM sleep behavior disorder."</p>
Data from: Gut microbiota composition and functionality are associated with REM sleep duration and continuous glucose levels
<p><span><strong>Context</strong>:</span><span> Sleep disruption is associated with poorer glucose metabolic control and altered gut microbiota in animal models.</span></p> <p><span><strong>Objective</strong>:</span><span> We aimed to evaluate the possible links among REM sleep duration, continuous glucose levels, and gut microbiota composition.</span></p> <p><strong><span>Design</span></strong><span>: This is an observational, prospective, real-life, cross-sectional case-control study. </span></p> <p><span><strong>Setting</strong>: </span><span>Tertiary Hospital recruiting healthy volunteers.</span></p> <p><span><strong>Patients or Other Participants</strong>:</span><span> One-hundred and eighteen (60 with obesity), middle-aged (39.1-54.8) subjects.</span></p> <p><span><strong>Intervention(s)</strong>:</span><span> Glucose variability and REM sleep duration were assessed by 10-day continuous glucose monitoring (CGM) (Dexcom G6®) and wrist-actigraphy (Fitbit Charge 3®), respectively</span></p> <p><span><strong>Main Outcome Measure(s)</strong>:</span><span>. Glucose variability was evaluated through standard deviation (SD), coefficient of variation (CV), and interquartile range (IQR). The percentage of time in range (% TIR), 126-139 mg/dL (TIR2), and 140-199 mg/dL (TIR3) were calculated. Shotgun metagenomics sequencing was applied to study gut microbiota taxonomy and functionality. </span></p> <p><span><strong>Results</strong>:</span><span> Increased glycemic variability (SD, CV, and IQR) was observed among subjects with obesity in parallel to increased % TIR2 and % TIR3. REM sleep duration was independently associated with the % TIR3 (β=-0.339; p<0.001) and glucose variability (SD, β=-0.350; p<0.001). Microbial taxa from Christensenellaceae family (Firmicutes phylum) were positively associated with REM sleep and negatively with glucose continuous monitoring levels, while bacteria from Enterobacteriacea family and bacterial functions involved in iron metabolism showed opposite associations. </span></p> <p><span><strong>Conclusions</strong>:</span><span> Decreased REM sleep duration was independently associated with a worse glucose profile. The associations of species from Christensenellaceae and Enterobacteriaceae families with REM sleep duration and continuous glucose values suggest an integrated picture of metabolic health.</span></p>
Fig 3 eYFP sustained inactivation controls, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data eYFP controls. Associated with Figure 3. for "Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla". Associated with Figure 3.</p>
Epigenetic clock estimations in patients with isolated REM Sleep Behavior Disorder
<p>Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for conversion to α-synucleinopathies. A continuum between aging and neurodegeneration has been proposed, but this hypothesis has not been tested in iRBD so far. Here we used epigenetic clocks, estimated from DNA methylation arrays using the DNA Methylation Age Calculator available at https://dnamage.genetics.ucla.edu/home, to measure biological aging in videopolysomnography-confirmed iRBD patients (iRBDs, n=28), videopolysomnography-negative controls (CTR_neg; n=57), and controls from the general population (CTR_pop; n=31)<strong>.</strong></p>
Data set of study The role of REM sleep in consolidating executive function: a prefrontal cortex perspective
Open the record for dataset details and reuse information.
Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)
ClinicalTrials.gov study NCT02708186. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism
ClinicalTrials.gov study NCT00695136. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Treatment of REM Sleep Behavior Disorder (RBD) With Sodium Oxybate
ClinicalTrials.gov study NCT04006925. IPD Sharing: NO. Countries: 1. Publications: 4.
Data from: Gut microbiota composition and functionality are associated with REM sleep duration and continuous glucose levels
Open the record for dataset details and reuse information.
Data from: REM sleep stabilizes hypothalamic representation of feeding behavior
<p>During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using <i>in vivo</i> calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LH<sup>vgat</sup>) show unique activity patterns during feeding that are reactivated during REM, but not NREM, sleep. REM sleep specific optogenetic silencing of LH<sup>vgat</sup> cells induced a re-organization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.</p>
Neurovascular coupling and bilateral connectivity during NREM and REM sleep
<p>Hemodynamic signals in the brain are used as surrogates of neural activity, but how these hemodynamic signals depend on arousal state is poorly understood. Here, we monitored neural activity and hemodynamic signals in un-anesthetized, head-fixed mice to understand how sleep and awake states impact cerebral hemodynamics. In parallel with electrophysiological recordings, we used intrinsic optical signal imaging to measure bilateral changes in cerebral hemoglobin ([HbT]), and two-photon laser scanning microscopy (2PLSM) to measure dilations of individual arterioles. We concurrently monitored body motion, whisker movement, muscle EMG, cortical LFP, and hippocampal LFP to classify the arousal state of the mouse into awake, NREM sleep, or REM sleep. We found that mice invariably fell asleep during imaging, and these sleep states were interspersed with periods of awake. During both NREM and REM sleep, mice showed large increases in [HbT] relative to the awake state, showing increase in hemoglobin and arteriole diameter two to five times larger than those seen in response to sensory stimulation. During NREM sleep, the amplitude of bilateral low-frequency oscillations in [HbT] increased markedly, and coherency between neural activity and hemodynamic signals was higher than the awake resting and REM states. Bilateral correlations in neural activity and [HbT] were highest during NREM sleep, and lowest in the awake state. Our results show that hemodynamic signals in the cortex are strongly modulated by arousal state, with hemodynamic changes during sleep being substantially larger than sensory-evoked responses. These results underscore the critical importance of behavioral monitoring during studies of spontaneous activity, as sleep-related hemodynamics dominate measures of neurovascular coupling and functional connectivity.</p>
Source Data for Infralimbic activity during REM sleep facilitates fear extinction memory
<p>Source data for the manuscript Infralimbic activity during REM sleep facilitates fear extinction memory</p>
Fig 4 AAVrg open loop, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recordings for AAVrg open loop experiments. Associated with Figure 4.</p>
Fig S4 hM4D(Gi) chemogenetic inhibition, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data for hM4D(Gi) experiments. Associated with Figure S4.</p>
Fig S4 mCherry controls, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recordings for mCherry controls. Associated with Figure S4.</p>
Fig 2 eYFP closed loop inactivation controls, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recordings for eYFP controls for Swichr++ control experiments. Associated with Figure 2D.</p>
Fig 1 ChR2 open loop, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data for 120 s optogenetic stimulation experiments. Associated with Figure 1.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.