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Dataset results
361 results for “RSV”
Transcriptomic response of human cells to SARS-CoV-2, RSV and H1N1 (STAR + StringTie)
<p>These data represent results from:</p> <ol> <li>Processing reads from 20 experiments (part of GSE147507) by following a standard approach, which includes using STAR to align the reads to GRCh38 and StringTie to calculate the (raw) counts per experiment. These results depict the transcriptomic response of human cells to SARS-CoV-2, RSV and H1N1, and enrichment analyses based on genes differentially expressed in SARS-CoV-2 but not in RSV or H1N1. (Authors: V.A.-P., M.G.F. and A.G.)</li> <li>Aligning to SARS-CoV-2 and quantifying reads by using HISAT2 and StringTie. (Author: C.R.-A.)</li> </ol> <p>Disclaimer: These results were obtained during the virtual BioHackathon 2020. As such, they are subject to ongoing research and have thus NOT yet undergone any scientific peer-review. That is, none of the contents can be considered to be free of errors and must be taken with caution!</p>
direct RNA seq data, triplicate of RSV - strain A2 in Calu-3 cells at 48 hours post infection
<p>Raw fastq data from Calue-3 cells infected with RSV strain A2</p>
ACCESS-AM2 model output for 2017-2018 MARCUS and 2018-2019 CAMMPCAN RSV Aurora Australis voyages
<p>The dataset includes model output from the ACCESS-AM2 model corresponding to the MARCUS (Measurements of Aerosols, Radiation and Clouds over the Southern Oceans) 2017-2018 voyages and the CAMMPCAN (Chemical and Mesoscale Mechanisms of Polar Cell Aerosol Nucleation) 2018-2019 voyages. The MARCUS voyages included a limited number of CAMMPCAN instruments while the CAMMPCAN voyages included the full suite of instruments. </p> <p>The model version used was ACCESS-AM2 (Australian Community Climate and Earth-System Simulator - Atmospheric Model Version 2) run with CMIP6 AMIP configuration, nudged with ERA5 reanalysis and full chemistry switched on. The model was configured with a horizontal resolution of 1.25◦ latitude and 1.875◦ longitude and 85 vertical levels. ACCESS-AM2 uses the UK Met Office’s Unified Model Global Atmosphere (UM10.6 GA7.1) as the atmosphere module, the Community Atmosphere Biosphere Land Exchange model version 2.5 (CABLE2.5) as the land-surface module and the Global Model of Aerosol Processes (GLOMAP-mode) as the aerosol module. More information on the ACCESS-AM2 model can be found at <a href="https://doi.org/10.1071/ES19033">https://doi.org/10.1071/ES19033</a>.</p> <p>The data is at daily means spanning 29-10-2017 to 26-03-2018 (149 days) for MARCUS, and 25-10-2018 to 24-03-2019 (151 days) for CAMMPCAN.</p> <p>Files included in this upload include:</p> <ul> <li>aa1718_cg893_track.nc: aerosol, chemistry, and meteorology model data for the MARCUS voyages</li> <li>cg893_daily_mean_MARCUS_size_distributions.nc: calculated aerosol size distribution model data for the MARCUS voyages </li> <li>aa1819_cg893_track.nc: aerosol, chemistry, and meteorology model data for the CAMMPCAN voyages</li> <li>cg893_daily_mean_CC_size_distributions.nc: calculated aerosol size distribution model data for the CAMMPCAN voyages</li> </ul> <p>File names refer to Aurora Australis, voyage years (either 2017-2018 or 2018-2019), followed by the model run and data type.</p> <p>An overview of the variable field names, variable long names, height profile availability and units available in the dataset is provided in VariablesOverview.xlsx. </p> <p>A Jupyter Notebook is also included and contains scripts that can be used to create figures for preliminary analysis using the model data.</p> <p>Additional information:</p> <ul> <li>MARCUS details: <a href="https://asr.science.energy.gov/meetings/stm/presentations/2017/473.pdf">https://asr.science.energy.gov/meetings/stm/presentations/2017/473.pdf</a></li> <li>CAMMPCAN details: <a href="https://findanexpert.unimelb.edu.au/project/102792-cammpcan-%E2%80%93-chemical-and-mesoscale-mechanisms-of-polar-cell-aerosol-nucleation">https://findanexpert.unimelb.edu.au/project/102792-cammpcan-%E2%80%93-chemical-and-mesoscale-mechanisms-of-polar-cell-aerosol-nucleation</a></li> <li>MARCUS Observations: <a href="https://doi.org/10.26179/5e54ab5e5d56f">https://doi.org/10.26179/5e54ab5e5d56f</a></li> <li>CAMMPCAN Observations: <a href="https://doi.org/10.26179/5e546f452145d">https://doi.org/10.26179/5e546f452145d</a> </li> </ul> <p>The GitHub repository containing the code used to produce these datasets can be found here: <a href="https://github.com/llamprey/aurora_voyages">https://github.com/llamprey/aurora_voyages</a></p> <p> </p> <p>Versions:</p> <p>1.0.0: Initial Version.</p> <p>1.1.0: Fixed bug where CN and CCN fields were incorrectly calculated.</p> <p>1.2.0: Updated aerosol size distribution files</p>
Safety, Tolerability, and Pharmacokinetics of RSV Monoclonal Antibody RSM01 in Healthy Adults
ClinicalTrials.gov study NCT05118386. IPD Sharing: YES. Countries: 1. Publications: 3.
Study of a Single Intramuscular Dose of Nirsevimab in the Prevention of Hospitalizations Due to Respiratory Syncytial Virus (RSV) Infection in Healthy Term and Preterm Infants During the First Year of
ClinicalTrials.gov study NCT05437510. IPD Sharing: YES. Countries: 3. Publications: 2.
Search strategies for a rapid review for economic modelling studies on RSV immunisation
<p>The dataset includes the complete, reproducible search strategies for all bibliographic databases searched during this project. The search strategies were designed to answer the following research question: </p> <p>What approaches are taken to modelling the expected costs and benefits of RSV immunisation in children and/or adults in high-income countries (as defined by the OECD)?</p> <p> </p>
RSV subgroup A direct RNA seq of infected MRC5 cells and mock infected MRC5 cells mRNA on nanopore
<p>Fastq files of mRNA sequenced by direct RNAseq on Oxford nanopore device and associated data for the paper</p>
Infant RSV immunoprophylaxis changes nasal epithelial DNAmethylation at 6 years of age
<p>Respiratory syncytial virus (RSV) infection has been associated with childhood wheeze and asthma, and potential mechanisms include persistent epigenetic effects. In the randomized, placebo-controlled MAKI trial (ISRCTN registry, number ISRCTN73641710), preterm infants randomly received RSV immunoprophylaxis with palivizumab or placebo during their first RSV season. DNA methylation in cells obtained by nasal brushes at age 6 was measured by Illumina MethylationEPIC array.</p> <p>This dataset contains summary statistics for the methylome-wide association study using DNAm data collected from 274 Children at age 6.</p> <p>The corresponding paper can be found here: https://pubmed.ncbi.nlm.nih.gov/34473906/.</p> <p>Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a Zenodo DOI generated for you go to ewascatalog.org/upload.</p>
Databases for NEXT-RSV-SEQ (RSV, HMPV, PIV)
<div> <div> <div> <div> <div> <div> <div> <div> <div> <div> <div> <div> <p>Here, we provide databases ready for use in sequencing read decontamination with our Next-RSV-SEQ pipeline (<a href="https://gitlab.com/rki_bioinformatics/next-rsv-seq" target="_new" rel="noreferrer">https://gitlab.com/rki_bioinformatics/next-rsv-seq</a>), designed for viral genome assembly using Illumina data.</p> <p><strong>Available Databases:</strong></p> <ul> <li><strong>Human orthopneumovirus / Human respiratory syncytial virus (RSV)</strong>: [RSV_GRCh38_2022-04-06.zip]</li> <li><strong>Human metapneumovirus (HMPV)</strong>: [HMPV_2022-05-28.zip]</li> <li><strong>Parainfluenza virus (PIV)</strong>: [PIV_2022-05-28.zip]</li> </ul> <p>These databases were created using <a href="https://github.com/DerrickWood/kraken2">Kraken2</a> and are based on all complete viral genome sequences available on NCBI Reference Sequence Database (<a href="https://www.ncbi.nlm.nih.gov/refseq/">RefSeq</a>) as of April 6, 2022 (for RSV), and May 28, 2022 (for HMPV and PIV). The RSV database also includes the human genome sequence GRCh38 (Genome Reference Consortium Human Build 38). The databases have been compressed into zip format for easy downloading. <strong>Before use, please unpack the respective zip archive.</strong></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div>
A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Adenovirus Serotype 26 Based Respiratory Syncytial Virus Pre-fusion (Ad26.RSV.Pre-F) Vaccine in RSV-Seronegative Toddlers 12 to 24
ClinicalTrials.gov study NCT03606512. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Safety and Reactogenicity Study of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3003891A) in Healthy Women
ClinicalTrials.gov study NCT02753413. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥50 Years of Age
ClinicalTrials.gov study NCT05330975. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study to Assess the Safety, Tolerability, and Immunogenicity of RSVpreF in Adults at High Risk of Severe RSV Disease
ClinicalTrials.gov study NCT05842967. IPD Sharing: YES. Countries: 1. Publications: 2.
A Study to Determine the Safety and Efficacy of the RSV F Vaccine to Protect Infants Via Maternal Immunization
ClinicalTrials.gov study NCT02624947. IPD Sharing: Not stated. Countries: 11. Publications: 1.
A Study to Evaluate the Safety and Immunogenicity of an Adjuvanted RSV Vaccine in Healthy Older Adults
ClinicalTrials.gov study NCT03572062. IPD Sharing: YES. Countries: 2. Publications: 1.
A Study to Assess the Safety, Reactogenicity and Immune Response of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3844766A) in Older Adults
ClinicalTrials.gov study NCT03814590. IPD Sharing: YES. Countries: 2. Publications: 1.
MEDI-524 (Motavizumab) for the Prevention of Respiratory Sycytial Virus (RSV) Disease Among Native American Indian Infants in the Southwestern United States
ClinicalTrials.gov study NCT00121108. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study on the Safety and Immune Response to an Unadjuvanted RSV Maternal Vaccine, in High Risk Pregnant Women Aged 15 to 49 Years and Infants Born to the Vaccinated Mothers
ClinicalTrials.gov study NCT04980391. IPD Sharing: YES. Countries: 9. Publications: 0.
Study of MEDI-524 (Motavizumab) for the Prophylaxis of Serious Respiratory Syncytial Virus (RSV) Disease in High-Risk Children
ClinicalTrials.gov study NCT00129766. IPD Sharing: Not stated. Countries: 24. Publications: 1.
Study of Safety, Reactogenicity and Immunogenicity of GlaxoSmithKline's (GSK)Respiratory Syncytial Virus (RSV)Maternal Unadjuvanted Vaccine in Healthy Pregnant Women (Aged 18 to 40 Years) and Their In
ClinicalTrials.gov study NCT04126213. IPD Sharing: YES. Countries: 9. Publications: 1.
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