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59 results for “Radiation Protection”
figure data for "Subsurface radiation environment of Mars and its implication for shielding protection of future habitats" by L.Röstel, J.Guo et al. 2020
<pre>This data of dose rates at different elevations above and below the Martian surface was modeled using the GEANT4-based AtRIS toolkit. Please refer to the following paper for reference and a detailed description of the model and scaling: „Subsurface radiation environment of Mars and its implication for shielding protection of future habitats“, L.Röstel, J.Guo et al. 2020 JGR: planets. List of files: AbsorbedDosePrimariesAR.txt - figures 2 in the paper EquivalentDosePrimariesAR.txt - figure 3 AbsorbedDoseSiliconSlabScenarios.txt - figure 4 AbsorbedDoseWaterSphereScenarios.txt - figure 5 EquivalentDoseWaterSphereScenarios.txt - figure 6 NeutronFlux.txt - figure 7 RequiredShieldingDepth.txt - figure 8</pre>
Protection from radiation-induced neuroanatomical deficits by CCL2-deficiency is dependent on sex
<p>This project investigated the impact of Ccl2 genotype status (+/+, +/-, -/-) on the brain structure changes induced by cranial radiation. Mn-enhanced MR images were acquired at P14, P23, P42, P63 and P98. Radiation (7-Gy) was delivered on P16 to the whole head, with a lead shield used to limit dose to the rest of the body. Further details are available in the manuscript.</p> <p>For the image processing, the registration was accomplished using the pydpiper toolkit (version 2.0.9), available on GitHub (https://github.com/Mouse-Imaging-Centre/pydpiper/tree/v2.0.9). A two-level registration was used. Key elements of that registration output are provided in this data posting.</p>
Supplemental Material: Study of radiation protection for the BELLA A-Cave
<p><strong>General description</strong></p> <p>Compressed archive containing the macro files and the scripts to run and analyze the results of the simulations of dose deposition in the BELLA A-Cave.</p> <p>The Geant4 scripts contain the parameters of the initial beam and of the computational mesh where the dose equivalent is deposited, the python scripts extract the data from the resulting OpenPMD files.</p> <p>The scripts include two possible configurations of shielding (Configuration 1 and Configuration 2) and the two initial beams investigated: a "realistic" distribution and an idealized 8 MeV monochromatic beam that represent the maximum point operationally achievable.</p> <p><strong>Configurations</strong></p> <p><em>Configuration 1:</em><strong> </strong></p> <p>It includes the following permanent shielding</p> <ul> <li><strong>Wall</strong>: the Cave A concrete walls, along with wall penetrations towards Cave B. All walls of Cave A are made of 36” thick concrete, except for the roof, the east wall and the entrance compartment walls which have a thickness of 24”. The penetrations for the beamline (from 1 to 3) and penetrations for the services (service penetrations in north, south, and east walls) are included in the simulations.</li> <li><strong>Pb1</strong> and <strong>Pb2</strong>: 8” thick Pb shielding filling the two wall penetrations towards Cave B which are closest to the Cave A interaction chamber.</li> <li><strong>Pb3</strong>: A Pb plate (10” width, 10” height, 1” thickness) positioned at the exit of the interaction chamber, perpendicular to the beam axis. The plate has a square hole (4 cm side) centered at the position of the electron beam axis. </li> <li><strong>Pb4</strong>: A Pb plate (20” width, 20” height, 1” thickness) placed at the west wall of Cave A, centered at the position of the electron beam axis.</li> <li><strong>SS1</strong> and <strong>SS2</strong>: stainless steel plates (2” thickness, 6” width, 2’ height) placed on both sides of the east wall, near the edges of penetration 3. The plates cover 3” of the window and 3” of the wall on both sides. The height of the plates is equal to the height of the opening.</li> </ul> <p><em>Configuration 2:</em></p> <p>In addition to the permanent shielding from Configuration 1, a tungsten (W) X-ray converter (0.5” width, 0.5” height, 2 mm thickness) is placed 3 cm downstream from the electron beam source. A 1”-wide and 4 cm long Pb shielding around the converter is considered.</p> <p><strong>Description of the archive</strong></p> <p>The archive is structure as follows</p> <pre><code class="language-bash">inputs_and_macros ├── Configuration_1__8MeV │ ├── input.mac │ ├── plot_dose_1_100_mrem_per_hour.py │ └── print_dose_values.py ├── Configuration_1__exp_distribution │ ├── input.mac │ ├── khz_energy.dat │ ├── plot_dose_1_100_mrem_per_hour.py │ └── print_dose_values.py ├── Configuration_2__8MeV │ ├── input.mac │ ├── plot_dose_1_100_mrem_per_hour.py │ └── print_dose_values.py └── Configuration_2__exp_distribution ├── input.mac ├── khz_energy.dat ├── plot_dose_1_100_mrem_per_hour.py └── print_dose_values.py</code></pre>
ATTENUATE (rAdpad proTecTion drapE iN redUcing rAdiaTion Exposure) Trial
ClinicalTrials.gov study NCT06233578. IPD Sharing: YES. Countries: 1. Publications: 0.
TG 91: Radiation Risk Inference at Low-Dose and Low-Dose Rate Exposure for Radiological Protection Purposes
<p>The detriment-adjusted nominal risk coefficients recommended by ICRP have been based, to a large extent, on data obtained from the atomic bomb survivors in Japan. ICRP introduced a Dose and Dose-Rate Effectiveness Factor (DDREF) of 2 to include in calculations of these risk coefficients for application at the low doses and low-dose rate exposures typical in radiological protection. The DDREF was included to account for the survivors’ single acute exposure, and because a linear quadratic instead of a linear risk to dose response was thought to be the most plausible biological model.</p> <p>This paper summarizes the recent work of ICRP Task Group 91 on this topic. Task Group activities have included reviews of the history of low-dose and low-dose-rate effects, various exposure scenarios and their doses and dose rates, radiation-induced effects at the molecular, cellular, animal, and human level, and biologically-based mechanistic models of carcinogenesis. The Task Group performed a meta-analysis of low-dose-rate epidemiological studies, and re-analyses of published results on radiation-induced effects among animal models and among Japanese atomic bomb survivors.</p>
Radiation Protection Perspective to Recurrent Medical Radiological Imaging
<p>The topic of recurrent radiological imaging of patients attracted attention due to the recent studies indicating the magnitude of this phenomenon and the associated higher cumulated individual exposure to be more extensive than previously known. Recurrent imaging is used for managing various health conditions and chronic diseases such as malignancies, trauma, end-stage kidney disease, cardiovascular diseases, Crohn’s disease, urolithiasis, cystic pulmonary disease. The published studies, although available from only a part of the world, triggered discussion at international level, including two IAEA technical meetings with representatives of the IAEA Member states and international organization. The conclusions to date were reflected in the published Joint Position Statement and Call for Action by nine international organizations aimed to prompt greater dialogue and engage different stakeholders in developing and implementing strategies and solutions focused upon improved radiation protection of patients with medical conditions which prompt more frequent imaging procedures. Such actions include improved access to dose saving imaging technologies; improved imaging strategies and appropriateness process; specific optimization tailored to the clinical condition and patient habitus; wider utilization of the automatic exposure monitoring systems with an integrated option for individual exposure tracking in standardized patient-specific risk metrics; improved training and communication. These might need strengthening in the radiation protection framework to ensure that patients with medical conditions which prompt more frequent imaging procedures receive needed medical care, without undue exposure to ionizing radiation. Standardized and easily available dose information in patient-specific metrics is needed to improve risk quantification. Consensus is still lacking on the proper utilization of the dose information from the previous procedures, and the concern of misuse and misinterpretation, especially by referring physicians and patients, needs to be addressed. Like any other aspect of medical uses of ionizing radiation, the competence and awareness of users of dose information is paramount, and this is linked to the knowledge, education, training and communication. The integration of the clinical and exposure history data will support research studies and improved knowledge about radiation risks from low doses and individual radiosensitivity. The radiation protection framework will need to respond to the challenge of recurrent imaging and high individual doses. The radiation protection perspective complements the clinical perspective, and the risk to benefit analysis must account in holistic for all incidental and long-term benefits and risks for patients, their clinical history and specific needs. This is a step toward the patient-centric healthcare.</p>
Data Visualization and Gendered Questions in Radiation Protection
<p>Recognition that age and biological sex are key factors in outcome of radiation exposure is reflected in the Discussion Paper on The Future of Radiological Protection. Use of a hypothetical "fixed" or universal exposure level in visualization of exposure outcomes in a large population such as the A bomb survivors, and application of a lifecycle model as compared to the population model are explored. The author is an evolutionary biologist with decades of national and global policy engagement, and she examines the efficacy of the idea of multiple standards from the perspective of the need for reparation.</p>
Attitudes of Staff Involved in Dental Radiological Procedures in Georgia Towards Radiation Protection and Safety: A Questionnaire-Based Study
<p>Objectives: To investigate dentist’s perceptions and attitudes regarding radiation safety in dental practices in Georgia.</p> <p>Methods: More than 100 dentists involved in dental X-ray diagnostic procedures across the country participated in this study. The questionnaire was submitted via Google form, a total of 17 key questions with relevant sub-questions. Further data were evaluated according to the frequency distribution. An anonymous survey was conducted regarding the following areas: years of practice, types and characteristics of the radiography equipment, knowledge of BSS and national regulations, prescription of dental radiographs, use of radiation protection equipment, participation in the radiation safety training program and etc.</p> <p>Results: The obtained data are presented in the form of tables and diagrams. Analysis of the answers showed a fairly high level of knowledge and responsibility for radiation safety among all survey participants. A certain difference in the answers depends both on work experience, education and on a number of other factors, for the study of which additional research is needed.</p> <p>Conclusions: This article is the first study in Georgia conducted jointly by a scientific organization, a national regulatory authority, as well as educational and professional structures. The analysis of the results of the presented questionnaire, on the one hand, allows the assessment of mandatory knowledge of radiation protection and safety issues of the target personnel. On the other hand, such feedback based on statistical data is a prerequisite for the revision of possible further regulatory requirements. Staff awareness issues involve the involvement of the relevant professional associations, which will allow it to strengthen the requirements for its members in the long run, as well as better analyze existing practices.</p>
Raw data fort the article: FLUOROSCOPY-GUIDED BILIARY PROCEDURES IN A PREGNANT, LIVER TRANSPLANT PATIENT: FETUS RADIATION PROTECTION
<p>We report three cases of clinically necessary, fluoroscopy-guided, percutaneous biliary procedures performed safely in a pregnant, liver transplant recipient using three different angiography suites. The uterine cumulative equivalent dose was 0.25 mSv, a value obtained by adding the doses of the three procedures described above, and which is relatively low when compared with the naturally occurring background radiation exposure for a 9-month pregnancy (~0.5-1 mSv). Our experience shows that staff knowledge, awareness and liaison promote the application of all dose reduction strategies possible while still achieving the clinical aim despite using different angiographic equipment.</p>
X-ray scattering datasets and simulations associated with the publication "Bio-SAXS of Single-Stranded DNA-Binding Proteins: Radiation Protection by the Compatible Solute Ectoine"
<p>This dataset contains the processed and analysed small-angle X-ray scattering data associated with all samples from the publications "Bio-SAXS of Single-Stranded DNA-Binding Proteins: Radiation Protection by the Compatible Solute Ectoine" (<a href="https://doi.org/10.1039/D2CP05053F">https://doi.org/10.1039/D2CP05053F</a>)</p> <p>Files associated with McSAS3 analyses are included, alongside the relevant SAXS data, with datasets labelled in accordance to the protein (G5P), its concentration (1, 2 or 4 mg/mL), and if Ectoine is present (Ect) or absent (Pure). PEPSIsaxs simulations of the GVP monomer (PDB structure: 1GV5 ) and dimer are also included.[1]</p> <p>TOPAS-bioSAXS-dosimetry extension for TOPAS-nBio based particle scattering simulations can be obtained from <a href="https://github.com/MarcBHahn/TOPAS-bioSAXS-dosimetry">https://github.com/MarcBHahn/TOPAS-bioSAXS-dosimetry</a> which is further described in <a href="https://doi.org/10.26272/opus4-55751">https://doi.org/10.26272/opus4-55751</a>.</p> <p>This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under grant number 442240902 (HA 8528/2-1 and SE 2999/2-1). We acknowledge Diamond Light Source for time on Beamline B21 under Proposal SM29806. This work has been supported by iNEXT-Discovery, grant number 871037, funded by the Horizon 2020 program of the European Commission.</p> <p>[1] S. Su, Y.-G. Gao, H. Zhang, T. C. Terwilliger and A. H.-J. Wang, Protein Science, 1997, 6, 771–780.</p> <p> </p> <p><br> </p>
Water is a radiation protection agent for ionised pyrrole
<p>Data and scripts for the manuscript with the title: Water is a radiation protection agent for ionised pyrrole</p>
Does the egg capsule protect against chronic UV-B radiation? A study based on encapsulated and decapsulated embryos of cuttlefish Sepia officinalis
<p>Although the egg capsule plays a crucial role in the embryonic development of cephalopods, its ability to protect embryos from Ultraviolet (UV) radiation is unknown. Our study evaluated the photoprotection mechanisms of <em>Sepia officinalis</em> to UV-B radiation and estimated the ability of the black capsule to act as a physical shield against it. Embryos with (BC) and without capsule (WC) and juveniles were exposed to four experimental UVB conditions for 55 days. The effects of different UVB doses were evaluated in terms of morphological abnormalities and differences in gene expression between each group. We observed that the development might be severely impaired in embryos exposed to UVB without capsule protection and these effects were time- and UVB-dose-dependent. In addition, we found variations in gene expression levels (light-sensitive, stress response, and DNA repair) in different tissues as a function of UVB doses. We suggest a relationship between morphological abnormalities and the limit of molecular regulation. These results suggest that the quantitative differences in expression are essential for defining the survivability of the embryo face to UVB. Thus, we demonstrated that the egg capsule could ensure successful embryonic development of the cuttlefish <em>S. officinalis</em> even at high doses of UVB.</p>
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Chil
ClinicalTrials.gov study NCT03989102. IPD Sharing: NO. Countries: 1. Publications: 7.
Protection of Rectum From High Radiation Doses
ClinicalTrials.gov study NCT01601691. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Radiation ProtEction for Dose RedUction in the Cardiac CathEter Lab Study: The REDUCE Trial
ClinicalTrials.gov study NCT06875583. IPD Sharing: YES. Countries: 1. Publications: 2.
Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adu
ClinicalTrials.gov study NCT03510481. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Does the egg capsule protect against chronic UV-B radiation? A study based on encapsulated and decapsulated embryos of cuttlefish Sepia officinalis
Open the record for dataset details and reuse information.
N-Acetylcysteine Protection Against Radiation Induced Cellular Damage
ClinicalTrials.gov study NCT04154982. IPD Sharing: NO. Countries: 1. Publications: 15.
EXTended pRotective Curtain Under Table to Reduce Operator RAdiation Dose in Percutaneous Coronary Procedures
ClinicalTrials.gov study NCT03259126. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali
ClinicalTrials.gov study NCT02627456. IPD Sharing: Not stated. Countries: 1. Publications: 4.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.