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411 results for “Radiation dose”
figure data for "Radiation environment and doses on Mars at Oxia Planum and Mawrth Vallis: support for exploration at sites with biosignature preservation potential", by F. Da Pieve, G. Gronoff, J. Guo et al (2020)
<p>The data are the tabular format of the plots in figures 2-7 of the paper submitted.</p> <p> </p>
Low dose rate radiation induced secretion of TGF-β3 together with an activator in small extracellular vesicles modifies low dose hyper-radiosensitivity through ALK1 binding
<p>This is a collection of results from all clonogenic assays on T-47D cells used in the manuscript "Low dose rate radiation induced secretion of TGF-β3 together with an activator in small extracellular vesicles modifies low dose hyper-radiosensitivity through ALK1 binding". </p> <p>T-47D cells were subjected to various pretreatments: low dose rate priming (0.1-0.3 Gy/h for 1 hour), small extracellular vesicles from irradiated or control cells, irradiated or control cell conditioned medium, MMP/ADAM inhibitor TAPI-2, recombinant TGF-B3, inhibitors of ALK1, ALK2, ALK5 or TGF-BRII, iNOS inhibitor 1400W, recombinant FKBP4, recombinant MMP14 and combinations of these. All pretreatments except low dose rate priming was administered for 24 hours. </p> <p>After pretreatments, cells were seeded to colonies and irradiated with 220 kV x-rays at a dose rate of 22.5 Gy/h or gamma rays from a Co-60 source at a dose rate of 20-25 Gy/h. </p> <p>Colonies were cultured for 2-3 weeks before fixation and manual counting. </p>
Evaluation of background ionizing radiation dose variation in Ploiesti city area, 2022
<p>Measurements of background ionizing radiation dose rate, done in Ploiesti city area in 2022 (Romania), by the student Tripac Flavius Gabriel under supervision of Prof. Dr. Adrian Iftime as part of a diploma thesis project (C.Davila University of Medicine and Pharmacy). </p> <p>A graphical overview of the values is included (ploiesti_values_2022.png). <br> </p>
Evaluation of background ionizing radiation dose variation in Bucharest city area, 2022
<p>Measurements of background ionizing radiation dose rate, done in Bucharest city area in 2022, by the student Damalan Daria Liana under supervision of prof. Adrian Iftime as part of a diploma thesis project.</p> <p>A graphical overview of the values is included (bucharest_values_2022.png).</p>
Dataset related to article "Phantom‑based analysis of variations in automatic exposure control across three mammography systems: implications for radiation dose and image quality in mammography, DBT, and CEM"
<p>The dataset comprises information from several DICOM tags extracted from digital mammography (DM), digital breast tomosynthesis (DBT), and contrast-enhanced mammography (CEM) images acquired in a phantom study aimed at characterizing the automatic exposure control (AEC) behavior of diverse mammography equipment. The final ten columns of the datasets encompass signal (mena pixel values, MPV) and noise (standard deviation, SD) measurements derived from phantom images. These measurements are used to compute several image quality metrics, including contrast, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), CNR relative difference in comparison to the 45 mm reference thickness, and a figure of merit (FOM) obtained by diving the squared CNR by the mean glandular dose (MGD).</p>
Data from: Non-invasive estimation of absorbed ionizing radiation dose in mice using Near-Infrared Spectroscopy (NIRS) and aquaphotomics
<p>Accurate measurement of ionizing radiation exposure, whether therapeutic or accidental, is of utmost importance in various scenarios. This paper presents a study that addresses this critical need by utilizing near-infrared (NIR) spectroscopy and aquaphotomics to estimate radiation dose exposure in mouse models subjected to X-ray irradiation. The analysis of NIR spectra acquired from the mouse abdomen enabled non-invasive estimation of radiation doses ranging from 0.5 to 6.5 Gy, immediately following the irradiation exposure. The findings were consistent with the impact of total body irradiation in mice, as evidenced by measures such as animal survival rate, alterations in body weight observed over a 30-day post-exposure period, and changes in hematocrit levels. The spectroscopic measurements were based on detecting changes in the molecular structure of body water after radiation exposure, utilizing the water spectral pattern as a multidimensional biomarker. While further validation in nonhuman primates is necessary, the findings demonstrate a simple, non-destructive, and rapid method that holds promise for the estimation of radiation exposure across a range of doses, applicable to both clinical applications and catastrophic radiation events. These advancements in radiation dose quantification have significant implications for the timely and precise assessment of radiation exposure in humans.</p>
Text-fig. 3. CT slices on Block 3. Invertebrate moulds (a, c) and remains of their hard skeletons (a, b). Large areas of limestone matrix hold either only a few scattered invertebrates or no fossil at all (b, c). Ring artefacts seen close to the isocentre of the scan (b, c) are a well-known phenomenon caused by the X-ray beams traversing the block at an insufficient radiation dose (as expected in such a large block of dense material), and are not part of any physical structure present therein (Triche et al. 2019). in Hidden Treasures Uncovered: Successful Detection Of Fossils Below The Surface In Large Limestone Blocks Using A Standard Medical X-Ray Ct Scanner
Text-fig. 3. CT slices on Block 3. Invertebrate moulds (a, c) and remains of their hard skeletons (a, b). Large areas of limestone matrix hold either only a few scattered invertebrates or no fossil at all (b, c). Ring artefacts seen close to the isocentre of the scan (b, c) are a well-known phenomenon caused by the X-ray beams traversing the block at an insufficient radiation dose (as expected in such a large block of dense material), and are not part of any physical structure present therein (Triche et al. 2019).
Data from: Non-invasive estimation of absorbed ionizing radiation dose in mice using Near-Infrared Spectroscopy (NIRS) and aquaphotomics
Open the record for dataset details and reuse information.
TG 91: Radiation Risk Inference at Low-Dose and Low-Dose Rate Exposure for Radiological Protection Purposes
<p>The detriment-adjusted nominal risk coefficients recommended by ICRP have been based, to a large extent, on data obtained from the atomic bomb survivors in Japan. ICRP introduced a Dose and Dose-Rate Effectiveness Factor (DDREF) of 2 to include in calculations of these risk coefficients for application at the low doses and low-dose rate exposures typical in radiological protection. The DDREF was included to account for the survivors’ single acute exposure, and because a linear quadratic instead of a linear risk to dose response was thought to be the most plausible biological model.</p> <p>This paper summarizes the recent work of ICRP Task Group 91 on this topic. Task Group activities have included reviews of the history of low-dose and low-dose-rate effects, various exposure scenarios and their doses and dose rates, radiation-induced effects at the molecular, cellular, animal, and human level, and biologically-based mechanistic models of carcinogenesis. The Task Group performed a meta-analysis of low-dose-rate epidemiological studies, and re-analyses of published results on radiation-induced effects among animal models and among Japanese atomic bomb survivors.</p>
Radiation-Induced Stem Cell Competition and Dose-Rate Effect
<p>A radiation biological effect of a given dose generally decreases with decreasing radiation dose rate, which is known as a “dose-rate effect”. The dose-rate effect demonstrated by many cellular and animal studies. Additionally, recent epidemiological study in high background radiation area in Kerala, India showed that cancer incidence did not increase with increasing cumulative dose (Jayalekshmi et al. Radiat Environ Med 2021). Tissue stem cells have been considered as a target of radiation-induced carcinogenesis. Radiation biological effect could be reduced if damaged stem cells are eliminated by stem cell competition. ICRP described that stem cell competition at the tissue level leaves an ample possibility for a dose-rate effective factor (DREF) value larger than unity, as in the case of the current dose and dose-rate effective factor (DDREF) value (ICRP Publication 131).</p> <p>Cells expressing Lgr5 are one of the major components of intestinal stem cells. Intestinal organoids are three-dimensional cultured tissue model generated from intestinal stem cells. To evaluate a radiation-induced stem cell competition, we established a quantitative method using mixed-organoid derived from two independent fluorescent protein-expressing Lgr5 stem cells, which one of stem cells were irradiated, for mimicking heterogeneous exposure under low-dose-rate irradiation. The organoid-forming potential (OFP) is one of the indices of the abilities of self-renewal, proliferation, and differentiation of stem cells. We found that irradiated stem cells exhibited a growth disadvantage in the mixed organoid, whereas the OFP of irradiated cells per se did not decrease significantly from that of non-irradiated cells.</p> <p>Additionally, we constructed a mathematical model to assess stem cell competition under low-dose-rate irradiation condition. In our model, a stem cell pool, containing a constant number of cells, was assumed, and changed through transition and turnover event. The intact cells turned into damaged cells through transition event which was assumed as the effect of radiation exposure. In the turnover event, a single cell was divided, and a single cell was eliminated from the stem cell pool. The probability of cell division and elimination depended on the properties of cells. The properties of damaged cells were different from that of intact cells. Under very low-dose-rate conditions, the radiation damage was suppressed when the damaged cells were less reproductive and tended to be eliminated compared to the intact cells.</p> <p>These results suggest the radiation-induced stem cell competition can be occurred in the intestine, and the stem-cell competition plays an important role in suppress carcinogenesis under low-dose-rate irradiation condition.</p>
Dose Escalation Trial of AZD1775 and Gemcitabine (+Radiation) for Unresectable Adenocarcinoma of the Pancreas
ClinicalTrials.gov study NCT02037230. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer
ClinicalTrials.gov study NCT02254278. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN
ClinicalTrials.gov study NCT03085719. IPD Sharing: NO. Countries: 1. Publications: 0.
SIR-Spheres Study to Calculate the Radiation-Absorbed Dose of 99mTc-MAA
ClinicalTrials.gov study NCT05848947. IPD Sharing: NO. Countries: 1. Publications: 3.
Study of SD-101 in Combination With Localized Low-dose Radiation in Patients With Untreated Low-grade B-cell Lymphoma
ClinicalTrials.gov study NCT02266147. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Evaluate the Safety, Biodistribution, Internal Radiation Dosimetry, and Effective Dose of DaTSCAN™ Ioflupane (123I) Injection in Chinese Healthy Volunteers.
ClinicalTrials.gov study NCT04564092. IPD Sharing: NO. Countries: 1. Publications: 1.
Protection of Rectum From High Radiation Doses
ClinicalTrials.gov study NCT01601691. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT02888743. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed Medulloblastoma
ClinicalTrials.gov study NCT00031590. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Breast Displacement and CT Radiation Dose
ClinicalTrials.gov study NCT01261559. IPD Sharing: Not stated. Countries: 1. Publications: 7.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.