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39 results for “Respiratory physiology”
Supplementary material of the article "OpenModelica-based virtual simulator for the cardiovascular and respiratory physiology of a neonate"
<p>This document contains the adjustment data for the parameters of the model presented in the article: "<strong>OpenModelica-based virtual simulator for the cardiovascular and respiratory physiology of a neonate</strong>"</p>
Whole-body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal
<p>Opioid use in the United States and abroad is an endemic part of society with yearly increases in overdose rates and deaths. As rates of overdose incidence increase, the use of the safe and effective reversal agent, naloxone, in the form of a nasal rescue spray is being fielded and used by emergency medical technicians (EMTs) at a greater and greater rate. Despite advances in the deployment of these rescue products, deaths are continuing to increase. There is evidence that repeated dosing of a naloxone nasal spray (such as Narcan) is becoming more common due to the amount and type of opiate being administered. Despite the benefits of naloxone related to opioid reversals, we lack repeated dosing guidelines as a function of opiates and the amount the patient has taken. Goal-directed rescue dosing, where respiratory markers such as oxygen saturation or end-tidal carbon dioxide, are being used as an indication of the patient's recovery. These rescue methods require time, training, and understanding by the EMT to administer with most patients receiving naloxone doses with no follow-up or additional monitoring. To measure repeat dosing guidelines, we construct a whole-body model of the pharmacokinetics and dynamics of an opiate, fentanyl on respiratory depression. We then construct a model of nasal deposition and administration of naloxone to investigate repeat dosing requirements for large overdose scenarios. We demonstrate that naloxone is highly effective at reversing the respiratory symptoms of the patient and recommend dosing requirements as a function of the fentanyl amount administered. By designing the model to include circulation and respiration we investigate physiological markers that may be used in goal-directed therapy rescue treatments.</p>
Whole-body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal
Open the record for dataset details and reuse information.
The Burden of Reproduction in Lizards: Changes in Respiratory Physiology Associated with Reduced Lung Volume at the Sevilleta National Wildlife Refuge (2007-2008)
Previous morphological work on lizards suggests that the volume of growing eggs may result in a significant decrease in lung volume during gravidity. Iguanid lizard lungs are located within continuous thoracic and abdominal cavities and are highly distensible. Because of their distensible nature and lack of a diaphragm, both naturally occurring and introduced structures within the abdominal and thoracic cavities (i.e. organs, food, eggs) compress them and potentially reduce available lung volume for gas exchange. During reproduction, this decrease comes at a time of increased energetic demands, due to the cost of provisioning eggs and the physical burden of transporting the extra mass before laying. This means that females must increase the oxygen/carbon dioxide exchange with effectively smaller lung capacity than when they are not reproductive. Therefore, the way species compensate for this decrease affects performance, and ultimately the survival of individuals and their offspring.
Physiological Effects of Nebulized Salbutamol in Acute Respiratory Failure Patients on HFNC
ClinicalTrials.gov study NCT06815679. IPD Sharing: NO. Countries: 1. Publications: 3.
Physiological Phenotyping of Respiratory Outcomes in Infants Born Premature
ClinicalTrials.gov study NCT03906708. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Assessment of Physiological Parameters Measurements (Heart Rate, Respiratory Rate, and Oxygen Saturation) by Standard Acquisition System Compared Remote Photoplethysmography Imaging System l
ClinicalTrials.gov study NCT04660318. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Physiologic Effects of High Flow Nasal Therapy in Patients With Acute Hypoxemic Respiratory Failure (OPTIFLOW)
ClinicalTrials.gov study NCT01056952. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Abnormalities in Lung Computed Tomography and Physiological Alterations in Patients With Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT02799940. IPD Sharing: NO. Countries: 1. Publications: 15.
Validation of Study in Respiratory Physiology and it Interactions
ClinicalTrials.gov study NCT01881945. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics
ClinicalTrials.gov study NCT02363920. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers
ClinicalTrials.gov study NCT05512585. IPD Sharing: NO. Countries: 1. Publications: 7.
Analysis of Advanced Physiological Ventilatory Parameters During Spontaneous Breathing Effort in Patients with Acute Hypoxemic Respiratory Failure
ClinicalTrials.gov study NCT06490523. IPD Sharing: NO. Countries: 1. Publications: 17.
Pilot Study of Physiological Effect of High-Flow Nasal Cannula on Respiratory Pattern and Work of Breathing
ClinicalTrials.gov study NCT02514798. IPD Sharing: NO. Countries: 1. Publications: 10.
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
ClinicalTrials.gov study NCT06694311. IPD Sharing: YES. Countries: 1. Publications: 1.
Ultrasound and Respiratory Physiological Signals in Lung Diseases
ClinicalTrials.gov study NCT06068647. IPD Sharing: NO. Countries: 1. Publications: 8.
Evaluation of Respiratory Heast Loss as a Physiologic Patient Monitor for Acute Care Medicine
ClinicalTrials.gov study NCT01808963. IPD Sharing: Not stated. Countries: 1. Publications: 0.
This Study Assess Some Physiological Parameters, Blood Picture, and Hemodynamic Parameters, Blood Pressure, Respiratory Assess by SPO2, During Different Periods in Laparoscopic Surgery
ClinicalTrials.gov study NCT06473194. IPD Sharing: NO. Countries: 0. Publications: 5.
Effects of Inspiratory Muscle Warm-up on Respiratory Variables, Physiological Indices, and 400-meter Performance in Elite Male Runners - Randomized Crossover Trial
ClinicalTrials.gov study NCT06886503. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
ClinicalTrials.gov study NCT05675345. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.