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59 results for “Reverts”
SGLT2-Inhibition reverts urinary peptide changes associated with severe COVID-19: an in-silico proof-of-principle of proteomics-based drug repurposing
<p>Severe COVID-19 is reflected by significant changes in urine peptides. Based on this observation, a clinical test predicting COVID-19 severity, CoV50, was developed and registered as in vitro diagnostic in Germany. We have hypothesized that molecular changes displayed by CoV50, likely reflective of endothelial damage, may be reversed by specific drugs. Such an impact by a drug could indicate potential benefits in the context of COVID-19. To test this hypothesis, urinary peptide data from patients without COVID-19 prior to and after drug treatment were collected from the human urinary proteome database. The drugs chosen were selected based on availability of sufficient number of participants in the dataset (n>20) and potential value of drug therapies in the treatment of COVID-19 based on reports in the literature. In these participants without COVID-19, spironolactone did not demonstrate a significant impact on CoV50 scoring. Empagliflozin treatment resulted in a significant change in CoV50 scoring, indicative of a potential therapeutic benefit. The study serves as a proof-of-principle for a drug repurposing approach based on human urinary peptide signatures. The results support the initiation of a randomised control trial testing a potential positive effect of empagliflozin for severe COVID-19, possibly via endothelial protective mechanisms.</p>
Data from: Recent decadal drought reverts warming–triggered growth enhancement in contrasting climates in the southern Andes treeline
Aims: Rising temperature and declining summer precipitation due to the 1970s-climate shift in southern South America have reduced forest productivity at dry sites. Here, we worked with the most widespread Southern Hemisphere treeline species, Nothofagus pumilio, across contrasting climatic conditions and determined whether rising atmospheric CO2 concentrations as well as warmer and drier climatic conditions provoked by the 70s-climatic shift have been causing systematic changes in treeline growth rates and intrinsic water-use efficiency (iWUE).Location: 36–54° S, southern Andes. Time period: 1950–2010. Major taxa studied: Nothofagus pumilio. Methods: We worked at five disparate climatic treeline locations, spanning 18 degrees of latitude; at each location, we sampled trees at four different elevations, including treeline elevation. We quantified the variation of annual tree-ring width (TRW) as a function of climate, elevation, tree age, size, annual CO2 concentrations, and location, using linear mixed-effects models and interpreted TRW trends in relation to iWUE and isotope (δ13C and δ18O) signalling. Results: Across locations, the patterns of treeline growth occurring in the 1980–2010 period exhibited a clear and significant negative trend, in contrast to the previous 1950–1980 period. We found an increase of iWUE and δ18O across time and locations. Given that an increase in δ18O indicates a decrease in stomatal conductance, we assert that drought-induced stomatal closure appears to be causing the reduction in growth. Main conclusions: We show unequivocal evidence that warmer and drier summer conditions translated into a decrease of growth rates along the elevational treeline of the southern Andes, reverting previous growth improvements linked to climate warming. An improvement in iWUE at all locations is most likely explained by decreased stomatal conductance given the rising δ18O signal. An iWUE–growth decoupling may act as an ecological strategy to respond to drought.
Understanding Transaction-Reverting Faults in Smart Contracts
<div> <h1>Understanding Transaction-Reverting Faults in Smart Contracts</h1> </div> <p>This project aims to provide a benchmark for smart contract developers and researchers to enhance their understanding of transaction-reverting faults (TR faults) in smart contracts. The project is associated with a paper titled <strong>Understanding Transaction-Reverting Faults in Smart Contracts</strong>.</p> <div> <h2>Dataset Description</h2> </div> <div> <h3>Overview</h3> </div> <p>We identify 301 real-world TR faults from open-source GitHub project and categorize them into machine auditable and machine unauditable faults. Among these faults, 224 (74.4%) fall into the machine auditable category, while the remaining 77 (25.6%) fall into the machine unauditable category. For detailed information on these 301 TR fault contracts, please refer to the <a href="../api/records/11889080/draft/files/TRFaults.zip/content" target="_blank" rel="noopener noreferrer">TRFaults.zip</a>. For more details, please refer to our GitHub repo. </p> <div> <h3>Folder Structure</h3> </div> <p>The dataset is structured into four distinct sections within the <a href="../api/records/11889080/draft/files/TRFaults.zip/content" target="_blank" rel="noopener noreferrer">TRFaults.zip</a> :</p> <ul> <li>machine_auditable_faults: includes the buggy and patched version of the 224 machine auditable faults.</li> <li>machine_unauditable_faults: includes the buggy and patched version of the 77 machine unauditable faults.</li> <li>machine_auditable_faults.csv: contains detailed information of each machine auditable fault, including the commit URL, category, and project type.</li> <li>machine_unauditable_faults.csv: contains the detailed information of each machine unauditable fault, including the commit URL, category, and project type.</li> </ul>
Critical transitions and evolutionary hysteresis in movement: Habitat fragmentation can cause abrupt shifts in dispersal that are difficult to revert
<p>Under habitat fragmentation, plant species' survival hinges on the ability of individuals to disperse from one habitat patch to another. While there is evidence that severe habitat fragmentation leads to evolution of reduced dispersal ability and that such decreased mobility is generally detrimental for species' survival, it is unknown whether species adapt via a gradual loss in dispersal ability or via a sudden shift from frequent to infrequent dispersal between patches (i.e., a critical transition). Using both a spatially explicit deterministic and individual-based stochastic model of hydrochorous seed dispersal, we show that a small increase in inter-patch distance can generate an abrupt shift in plant seed dispersal strategy from long to short distances. Most importantly, we found that a substantial increase in connectivity between habitat fragments is required to reverse this loss of long-distance dispersal, due to an evolutionary hysteresis effect. Our theory prompts for re-consideration of the eco-evolutionary consequences of habitat fragmentation as restoring habitat connectivity may require restoration of much higher connectivity levels than currently assumed.</p>
Relieving Vasomotor Symptoms Effectively With Bioidentical Hormone Replacement Therapy: The REVERT Study
ClinicalTrials.gov study NCT01862861. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Dementias and Microbiota Composition: Is Possible to Revert the Dementia Symptoms Reverting the Microbiota Composition?
ClinicalTrials.gov study NCT05943925. IPD Sharing: UNDECIDED. Countries: 1. Publications: 23.
Critical transitions and evolutionary hysteresis in movement: Habitat fragmentation can cause abrupt shifts in dispersal that are difficult to revert
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Data from: Recent decadal drought reverts warming–triggered growth enhancement in contrasting climates in the southern Andes treeline
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Data from: Alzheimer Disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal
<p>Objective: To identify potential predictors for outcome in individuals with mild cognitive impairment (MCI) who have reverted to normal cognition (NC).</p> <p>Methods: We selected individuals with MCI, who reverted at follow-up to NC, with follow-up after reversion from ADNI. Common clinical markers, AD biomarkers, and neurodegeneration imaging markers were used to compare MCI reverters based on subsequent clinical outcome (i.e. subsequent decline or stable reversion). For independent comparison, findings of the clinical Amsterdam Dementia Cohort are presented.</p> <p>Results: Seventy-seven (10%) out of 757 individuals with MCI reverted to NC and 61 individuals of these had follow-up data available. After 3.2±2.2 years 16 (24%) progressed to MCI, and 3 (5%) to dementia. Those who declined were older and had a higher amyloid PET burden and higher cerebrospinal fluid (CSF) tau levels.</p> <p>Conclusion: In MCI reverters, abnormal biomarkers for AD pathology are associated with subsequent decline. AD biomarkers may aid in the prognosis of reverting MCI.</p>
Data from: Reverting ontogeny: rapid phenotypic plasticity of color vision in cichlid fish
Phenotypic plasticity, particularly during development, allows organisms to rapidly adjust to different environmental conditions. Yet, it is often unclear whether the extent and direction of plastic changes are restricted by an individual's ontogeny. Many species of cichlid fishes go through ontogenetic changes in visual sensitivity, from short to long wavelengths, by switching expression of cone opsin genes crucial for color vision. During this progression, individuals often exhibit phenotypic plasticity to the ambient light conditions. However, it is commonly assumed that once an adult visual phenotype is reached, reverting to an earlier ontogenetic state with higher sensitivity at shorter wavelengths is not common. In this study, we experimentally demonstrate that four-month-old Midas cichlid fish (Amphilophus astorquii) show plasticity in single cone opsin expression after experiencing drastic changes in light conditions. Resulting shifts of visual sensitivity occurred presumably in an adaptive direction - towards shorter or longer wavelengths when exposed to short or long wavelength light, respectively. Single cone opsin expression changed within only a few days and went through a transitional phase of co-expression. When the environment was experimentally enriched in long wavelength light, the corresponding change occurred gradually along a dorsoventral gradient within the retina. This plasticity allowed individuals to revert earlier ontogenetic changes and return to a more juvenile visual phenotype demonstrating previously unrecognized insights into temporal and spatial dynamics of phenotypic plasticity of the visual system in response to ambient light.
NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy
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Data of study "Time-restricted feeding obesogenic food is sufficient to revert neurocognitive deficits
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Data from: Alzheimer Disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal
Open the record for dataset details and reuse information.
Data from: Reverting ontogeny: rapid phenotypic plasticity of color vision in cichlid fish
Open the record for dataset details and reuse information.
small RNA libraries from petals of Antirrhinum majus (sulf mutant and wild-type revertants)
GEO Series GSE91378. Antirrhinum majus. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer
GEO Series GSE297099. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
After demyelination in the adult CNS, oligodendrocyte precursor cells revert to an immature mRNA profile and express immune cues favoring their migration
GEO Series GSE48872. Mus musculus. 18 samples. Type: Expression profiling by array.
Exchange of subtelomeric regions between chromosomes 4q and 10q: a novel way to revert the FSHD genotype and phenotype
GEO Series GSE254310. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
AMPK activation reverts mouse epiblast stem cells to naïve state
GEO Series GSE157087. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
AMPK activation reverts mouse epiblast stem cells to naïve state
GEO Series GSE175610. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.