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5 results for “Reward anticipation”
Data Set related to Synaptic inhibition in the lateral habenula shapes reward anticipation.
<p>The lateral habenula (LHb) supports learning processes enabling the prediction of upcoming rewards. While reward-related stimuli decrease the activity of LHb neurons, whether this anchors on synaptic inhibition to guide reward-driven behaviors remains poorly understood. Here, we combine in vivo two-photon calcium imaging with Pavlovian conditioning in mice and report that anticipatory licking emerges along with decreases in cue-evoked calcium signals in individual LHb neurons. In vivo multiunit recordings and pharmacology reveal that the cue-evoked reduction in LHb neuronal firing relies on GABA<sub>A</sub>-receptor activation. In parallel, we observe a postsynaptic potentiation of GABA<sub>A</sub>-receptor-mediated inhibition, but not excitation, onto LHb neurons together with the establishment of anticipatory licking. Finally, strengthening or weakening postsynaptic inhibition with optogenetics and GABA<sub>A</sub>-receptor manipulations enhances or reduces anticipatory licking, respectively. Hence, synaptic inhibition in the LHb shapes reward anticipation.</p>
Temporally specific patterns of neural activity in interconnected corticolimbic structures during reward anticipation
<p>Temporally specific patterns of neural activity in interconnected corticolimbic structures during reward anticipation</p> <p>Megan E. Young, Camille Spencer-Salmon, Clayton Mosher, Sarita Tamang, Kanaka Rajan, and Peter H. Rudebeck</p> <p>This dataset contains peripheral physiology (heart rate) and single neuron activity data from the paper entitled “Temporally specific patterns of neural activity in interconnected corticolimbic structures during reward anticipation” by Young, Spencer-Salmon and colleagues.</p> <p>The study investigated how neurons in macaque subcallosal anterior cingulate cortex, basolateral amygdala, and rostromedial striatum encoded anticipated reward during Pavlovian and instrumental tasks.</p> <p>Heart rate data were pre-processed using methods described in the paper and were downsampled to 50 Hz for analysis. Neural activity data were pre-processed using steps as described in the paper.</p> <p>The dataset is saved as .MAT files.</p> <p>Files included:</p> <p>‘Pavlovian_task_neurons.mat’ – single neuron data from the Pavlovian task. Each of the 656 rows represents a single neuron and its associated information.</p> <p>‘Instrumental_task_neurons.mat’ – single neuron data from the instrumental task. Each of the 425 rows represents a single neuron and its associated information.</p> <p>“heart_rate.mat” – heart rate data from monkeys D and H.</p> <p><br> File structure and information:</p> <p>Pavlovian_task_neurons.mat</p> <p>Structure “Pavlovian_task_neurons”<br> - “Pavlovian_task_neurons.unit_name” – neuron specific identifier<br> - “Pavlovian_task_neurons.monkeynumber” – subject specific #<br> - “Pavlovian_task_neurons.monkeyname” – subject specific name<br> - “Pavlovian_task_neurons.date” – date on which data were recorded<br> - “Pavlovian_task_neurons.session” – session identifier from date (a-d)<br> - “Pavlovian_task_neurons.channel” – recording channel data recorded from<br> - “Pavlovian_task_neurons.wavemark” – waveform number (a-e)<br> - “Pavlovian_task_neurons.brainarea” – brain area where neuron recorded (SC = subcallosal ACC, AMY = basolateral amygdala, VS = rostromedial striatum).<br> - “Pavlovian_task_neurons.areanum” – # brain area (subcallosal ACC = 1, BLA = 2, rostromedial striatum = 3)<br> - “Pavlovian_task_neurons.condition” – condition # from Monkey Logic for each of the trials (1 by n trials)<br> - “Pavlovian_task_neurons.stimspikes” – smoothed spike rate from -600 to 2500ms after stimulus onset (trials by time matrix)<br> - “Pavlovian_task_neurons.rewardspikes” – smoothed spike rate from -600 to 2500ms after reward onset (trials by time matrix)<br> - “Pavlovian_task_neurons.stimID” – stimulus shown on that trial (1 = neutral, 3 = CS+ juice, 4 = CS+ water, 5 = CS-) (1 by n trials).</p> <p><br> Instrumental_task_neurons.mat</p> <p>Structure “Instrumental_task_neurons”<br> - “instrumental_task_neurons.unit_name” – neuron specific identifier<br> - “instrumental_task_neurons.monkeynumber” – subject specific #<br> - “instrumental_task_neurons.monkeyname” – subject specific name<br> - “instrumental_task_neurons.date” – date on which data were recorded<br> - “instrumental_task_neurons.session” – session identifier from date (a-d)<br> - “instrumental_task_neurons.channel” – recording channel data recorded from<br> - “instrumental_task_neurons.wavemark” – waveform number (a-e)<br> - “instrumental_task_neurons.brainarea” – brain area where neuron recorded (SC = subcallosal ACC, AMY = basolateral amygdala, VS = rostromedial striatum).<br> - “instrumental_task_neurons.areanum” – # brain area (subcallosal ACC = 1, BLA = 2, rostromedial striatum = 3)<br> - “instrumental_task_neurons.condition” – condition 7-18 from Monkey Logic for each of the trials (1 by n trials). CNDs 7,8,13,14= CS+ juice vs CS+ water; CNDs 9,10,15,16= CS+ juice vs CS-; CNDs 11,12,17,18= CS+ water vs CS-.<br> - “instrumental_task_neurons.choice” – outcome associated with chosen option (0=nothing, 1=juice, 2=water) (1 by n trials)<br> - “instrumental_task_neurons.unchosen” - outcome associated with unchosen option (0=nothing, 1=juice, 2=water) (1 by n trials)<br> - “instrumental_task_neurons.chosenside” – side of the screen chosen (left [0] or right [1]) (1 by n trials)<br> - “instrumental_task_neurons.stimspikes” – smoothed spike rate from -600 to 2500ms after stimulus onset (trials by time matrix)<br> - “instrumental_task_neurons.rewardspikes” – smoothed spike rate from -600 to 2500ms after reward onset (trials by time matrix)</p> <p>heart_rate.mat</p> <p>Structures – “monkey_d_hr” – monkey D heart rate data<br> – “monkey_h_hr” – monkey H heart rate data</p> <p>Structure of monkey_d/h_hr<br> - “monkey_d/h_hr.trial_type” – trial type presented (1 = neutral, 2 = unsignaled, 3 = CS+ juice, 4 = CS+ water, 5 = CS-) (1 by n trials).<br> - “monkey_d/h_hr.trials” – number of trials in each session by trial type<br> - “monkey_d/h_hr.session – percent change in heart rate for each trial from -200 ms to 3500ms after stimulus onset. Column 1 = session; Column 2 = trial type; Column 3 = trial number; Columns 4 – 3703 = percent change in heart rate.</p> <p> </p>
Gut microbiome in ADHD and its relation to neural reward anticipation (PLOS ONE, 2017)
<p>fMRI group data belonging to publication Gut microbiome in ADHD and its relation to neural reward anticipation (PLOS ONE, 2017)</p>
The Role of Consumption and Anticipation in Dopamine Release to Food Reward
ClinicalTrials.gov study NCT03447561. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Chronic stress deficits in reward behaviour co-occur with low nucleus accumbens dopamine activity during reward anticipation specifically
GEO Series GSE268460. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
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