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20 results for “Rift Valley fever”
Continuous phylogeography analysis of Rift Valley fever virus (RVFV) in Africa and the Arabian Peninsula
<p>Spatiotemporal-explicit Bayesian phylogenetic trees and MCMC log files for Rift Valley fever virus large, medium and non-structural genetic sequences generated by BEAST v1.10</p> <ol> <li>Log files (logs.zip)</li> <li>Tree files (trees.zip)</li> </ol>
Reanalysis of the 2000 Rift Valley fever outbreak in Southwestern Arabia
<p>The first documented Rift Valley hemorrhagic fever outbreak in the Arabian Peninsula occurred in northwestern Yemen and southwestern Saudi Arabia from August 2000 to September 2001. This Rift Valley fever outbreak is unique because the virus was introduced into Arabia during or after the 1997-1998 East African outbreak and before August 2000, either by wind-blown infected mosquitos or by infected animals, both from East Africa. A wet period from August 2000 into 2001 resulted in a large number of amplification vector mosquitoes, these mosquitos fed on infected animals, and the outbreak occurred. More than 1,500 people were diagnosed with the disease, at least 215 died, and widespread losses of domestic animals were reported. Using a combination of satellite data products, including 2 x 2 m digital elevation images derived from commercial satellite data, we show rainfall and potential areas of inundation or water impoundment were favorable for the 2000 outbreak. However, favorable conditions for subsequent outbreaks were present in 2007 and 2013, and very favorable conditions were also present in 2016-2018. The lack of subsequent Rift Valley fever outbreaks in this area suggests that Rift Valley fever has not been established in mosquito species in Southwest Arabia, or that strict animal import inspection and quarantine procedures, medical and veterinary surveillance, and mosquito control efforts put in place in Saudi Arabia following the 2000 outbreak have been successful. Any area with Rift Valley fever amplification vector mosquitos present is a potential outbreak area unless strict animal import inspection and quarantine procedures are in place.</p>
Data from: Modelling vaccination strategies against Rift Valley fever in livestock in Kenya: model code
The impacts of vaccination on the transmission of Rift Valley fever virus (RVFV) have not been evaluated. We have developed a RVFV transmission model comprising two hosts -- cattle as a separate host and sheep and goats as one combined host (herein after referred to as sheep) -- and two vectors -- Aedes species (spp) and Culex spp -- and used it to predict the impacts of: (1) reactive vaccination implemented at various levels of coverage at pre-determined time points, (2) targeted vaccination involving either of the two host species, and (3) a periodic vaccination implemented biannually or annually before an outbreak. Methodology/Principal Findings: The model comprises coupled vector and host modules where the dynamics of vectors and hosts are described using a system of difference equations. Vector populations are structured into egg, larva, pupa and adult stages and the latter stage is further categorized into three infection categories: susceptible, exposed and infectious mosquitoes. The survival rates of the immature stages (egg, larva and pupa) are dependent on rainfall densities extracted from the Tropical Rainfall Measuring Mission (TRMM) for a Rift Valley fever (RVF) endemic site in Kenya over a period of 1827 days. The host populations are structured into four age classes comprising young, weaners, yearlings and adults and four infection categories including susceptible, exposed, infectious, and immune categories. The model reproduces the 2006/2007 RVF outbreak reported in empirical surveys in the target area and other seasonal transmission events that are perceived to occur during the wet seasons. Mass reactive vaccination strategies greatly reduce the potential for a major outbreak. The results also suggest that the effectiveness of vaccination can be enhanced by increasing the vaccination coverage, targeting vaccination on cattle given that this species plays a major role in the transmission of the virus, and using both periodic and reactive vaccination strategies. Conclusion/Significance: Reactive vaccination can be effective in mitigating the impacts of RVF outbreaks but practically, it is not always possible to have this measure implemented satisfactorily due to the rapid onset and evolution of RVF epidemics. This analysis demonstrates that both periodic and reactive vaccination ought to be used strategically to effectively control the disease.
A Study to Assess the New Candidate Rift Valley Fever Virus Vaccine in Healthy Adults
ClinicalTrials.gov study NCT04672824. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Modelling vaccination strategies against Rift Valley fever in livestock in Kenya: model code
Open the record for dataset details and reuse information.
Rift Valley Fever reported outbreaks from 2006 to January 2020
<p>This is a movie map showing the Rift Valley Fever outbreaks in animals and humans reported by OIE and WHO respectively since 2006 until January 2020.</p>
Safety and Immunogenicity Study of Rift Valley Fever Vaccine
ClinicalTrials.gov study NCT00584194. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety/Immunogenicity/Genetic Drift of MP-12 Rift Valley Fever Vaccine
ClinicalTrials.gov study NCT00415051. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Temporal alterations in the HSAEC transcriptome following infection by virulent and attenuated strains of Rift Valley Fever Virus
GEO Series GSE102481. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis
GEO Series GSE241547. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Correlative gene expression to protective seroconversion in Rift Valley Fever vaccinates
GEO Series GSE71417. Bos taurus. 45 samples. Type: Expression profiling by high throughput sequencing.
Alteration in the Culex pipiens transcriptome reveals the implication of the mosquito immune system during Rift Valley fever phlebovirus infection
GEO Series GSE142339. Culex pipiens. 18 samples. Type: Expression profiling by high throughput sequencing.
MAVS mediates a protective immune response in the brain to Rift Valley fever virus
GEO Series GSE200881. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effects of Rift Valley fever virus infection on gene expression and alternative splicing in HEK 293 cells
GEO Series GSE242551. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Characterization of nucleocapsid-RNA interactions in Rift Valley fever virus infected cells
GEO Series GSE186067. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Rift Valley Fever in Kenya
ClinicalTrials.gov study NCT00287014. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated
ClinicalTrials.gov study NCT00869713. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase 2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine
ClinicalTrials.gov study NCT03609398. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Immunogenicity of a Candidate Rift Valley Fever Vaccine (RVF003)
ClinicalTrials.gov study NCT06799234. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of MBT/Pas and BALB/cByJ MEFs response after infection with Rift Valley Fever virus
GEO Series GSE18064. Mus musculus. 12 samples. Type: Expression profiling by array.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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