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Dataset results
65 results for “Risk Tolerance”
Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPR
ClinicalTrials.gov study NCT02476006. IPD Sharing: YES. Countries: 16. Publications: 1.
The biogeography of thermal risk for terrestrial ectotherms: scaling of thermal tolerance with body size and latitude
1. Many organisms are shrinking in size in response to global warming. However, we still lack a comprehensive understanding of the mechanisms linking body size and temperature of organisms across their geographical ranges. Here we investigate the biophysical mechanisms determining the scaling of body temperature with size across latitudes in terrestrial ectotherms. 2. Using biophysical models, we simulated operative temperatures experienced by lizard-like ectotherms as a function of microclimatic variables, body mass and latitude and use them to generate null predictions for the effect of size on temperature across geographical gradients. We then compared model predictions against empirical data on lizards' field body temperature (Tb), and thermal tolerance limits (CTmax and CTmin). 3. Our biophysical models predicted that the allometric scaling of operative temperatures with body size varies with latitude, with a positive relationship at low latitudes that vanishes with increasing latitude. The analyses of thermal traits of lizards show a significant interaction of body size and latitude on Tb and CTmax and no effect of body mass on CTmin, consistent with model's predictions. The estimated scaling coefficients are within the ranges predicted by the biophysical model. The effect of body mass, however, becomes non-significant after controlling for the phylogenetic relatedness between species. 4. We propose that large-bodied terrestrial ectotherms exhibit higher risk of overheating at low latitudes, while size differences in thermal sensitivity vanish towards higher latitudes. 5. Our work highlights the potential of combining mechanistic models with empirical data to investigate the mechanisms underpinning broad-scale patterns and ultimately provide a null model to develop baseline expectations for further empirical research. 08-Jan-2020
A Study to Assess the Safety, Tolerability, and Immunogenicity of RSVpreF in Adults at High Risk of Severe RSV Disease
ClinicalTrials.gov study NCT05842967. IPD Sharing: YES. Countries: 1. Publications: 2.
Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children (GPAC) Study
ClinicalTrials.gov study NCT00346398. IPD Sharing: YES. Countries: 2. Publications: 3.
Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications
ClinicalTrials.gov study NCT01227967. IPD Sharing: Not stated. Countries: 5. Publications: 4.
Safety, Tolerability and Immunogenicity of Three Doses of Novartis Meningococcal B Vaccine When Administered to Healthy At-risk Adults
ClinicalTrials.gov study NCT00560313. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure
ClinicalTrials.gov study NCT01788228. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy, Safety, Tolerability, and Biomarkers of Ibudilast (MN-166) in Patients Hospitalized With COVID-19 at Risk for ARDS
ClinicalTrials.gov study NCT04429555. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigation of Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy of Oral Danirixin in Symptomatic COPD Subjects With Mild to Moderate Airflow Limitation at Risk for Exa
ClinicalTrials.gov study NCT02130193. IPD Sharing: Not stated. Countries: 2. Publications: 1.
CTLA4-Ig (Abatacept)for Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives At -Risk for Type 1
ClinicalTrials.gov study NCT01773707. IPD Sharing: Not stated. Countries: 2. Publications: 2.
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults at Increased Risk for Pneumococcal Disease (V114-017/PNEU-DAY)
ClinicalTrials.gov study NCT03547167. IPD Sharing: YES. Countries: 7. Publications: 1.
Long-term Safety and Tolerability of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY Long Term)
ClinicalTrials.gov study NCT01507831. IPD Sharing: Not stated. Countries: 27. Publications: 6.
Evaluating the Safety and Tolerability of Antiretroviral Drug Regimens Used as Pre-Exposure Prophylaxis to Prevent HIV Infection in At-Risk Men Who Have Sex With Men and in At-Risk Women
ClinicalTrials.gov study NCT01505114. IPD Sharing: Not stated. Countries: 2. Publications: 5.
Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)
ClinicalTrials.gov study NCT02666664. IPD Sharing: Not stated. Countries: 6. Publications: 9.
Promoting Tolerance to Peanut in High-Risk Children
ClinicalTrials.gov study NCT00329784. IPD Sharing: YES. Countries: 1. Publications: 9.
The biogeography of thermal risk for terrestrial ectotherms: scaling of thermal tolerance with body size and latitude
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Data from: Resistance, tolerance and environmental transmission dynamics determine host extinction risk in a load-dependent amphibian disease
Open the record for dataset details and reuse information.
Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension in Subjects at High Risk for Invasive Fungal Infections (P05520)
ClinicalTrials.gov study NCT01075984. IPD Sharing: YES. Countries: 0. Publications: 2.
The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes
ClinicalTrials.gov study NCT01795248. IPD Sharing: Not stated. Countries: 1. Publications: 19.
COVID-19 Study to Evaluate Safety, Tolerability, and Efficacy of REGN14256+Imdevimab for the Treatment of COVID-19 Adult and Adolescent Patients Without Risk Factors for Progression to Severe Disease
ClinicalTrials.gov study NCT05081388. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.