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4,078 results for “SARS”
Transcriptomic response of human cells to SARS-CoV-2, RSV and H1N1 (STAR + StringTie)
<p>These data represent results from:</p> <ol> <li>Processing reads from 20 experiments (part of GSE147507) by following a standard approach, which includes using STAR to align the reads to GRCh38 and StringTie to calculate the (raw) counts per experiment. These results depict the transcriptomic response of human cells to SARS-CoV-2, RSV and H1N1, and enrichment analyses based on genes differentially expressed in SARS-CoV-2 but not in RSV or H1N1. (Authors: V.A.-P., M.G.F. and A.G.)</li> <li>Aligning to SARS-CoV-2 and quantifying reads by using HISAT2 and StringTie. (Author: C.R.-A.)</li> </ol> <p>Disclaimer: These results were obtained during the virtual BioHackathon 2020. As such, they are subject to ongoing research and have thus NOT yet undergone any scientific peer-review. That is, none of the contents can be considered to be free of errors and must be taken with caution!</p>
Data for At-home testing to characterize SARS-CoV-2 seroprevalence among children and adolescents
<div> <div>This repository contains the data used to reproduce *At-home testing to characterize SARS-CoV-2 seroprevalence among children and adolescents* by Ahmed et al.</div> </div>
Data for SARS-CoV-2 Reinfection Trends in South Africa: Monthly Report (2022-12-07)
<p>This version contains a single file, with time series data for the most recent <a href="https://www.nicd.ac.za/diseases-a-z-index/disease-index-covid-19/surveillance-reports/sarscov2-reinfection-trends-in-south-africa-monthly-report/">monthly report on SARS­-CoV-­2 Reinfection Trends in South Africa</a>:</p> <ul> <li><code>ts_data.csv</code> - national daily time series of newly detected putative primary infections (<code>cnt</code>), suspected second infections (<code>reinf</code>), suspected third infections (<code>third</code>), and suspected fourth infections (<code>fourth</code>) by specimen receipt date (<code>date</code>)</li> </ul> <p>Note: There may be some inconsistencies with the numbers of infections through time in earlier versions of this data set due to back-filling of late-arriving data.</p> <p> </p> <p>Note: Earlier versions of this data set included data files for Pulliam, JRC, C van Schalkwyk, B Lombard, N Govender, A von Gottberg, C Cohen, MJ Groome, J Dushoff, K Mlisana, and H Moultrie. <a href="https://www.science.org/doi/10.1126/science.abn4947">Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa</a>. DOI: 0.1126/science.abn4947</p> <p>For code and more details see: <a href="https://github.com/jrcpulliam/reinfections/releases/tag/v3.0">https://github.com/jrcpulliam/reinfections/releases/tag/v3.0</a> or <a href="https://zenodo.org/record/6108448">10.5281/zenodo.6108448</a></p> <p>The version of this data set associated with the publication (available via the links above) included the following files:</p> <ul> <li><code>ts_data.csv</code> - national daily time series of newly detected putative primary infections (<code>cnt</code>), suspected second infections (<code>reinf</code>), suspected third infections (<code>third</code>), and suspected fourth infections (<code>fourth</code>) by specimen receipt date (<code>date</code>)</li> <li><code>demog_data.csv</code> - counts of individuals eligible for reinfection (<code>total</code>), who have 0 suspected reinfections (<code>no_reinf</code>) or >0 suspected reinfections (<code>reinf</code>) by province (<code>province</code>), age group (5-year bands, <code>agegrp5</code>), and sex (M = Male, F = Female, U = Unknown, <code>sex</code>)</li> <li><code>posterior_90_null.RData</code> - posterior samples from the MCMC fitting procedure (as used in the manuscript)</li> <li><code>sim_90_null.RDS</code> - simulation results (as used in the manuscript)</li> <li><code>emp_haz_sens_an.RDS</code> - output of sensitivity analysis of relative empirical hazard estimation to assumed observation probabilities (as used in the manuscript)</li> </ul>
Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention
<p>Single cell RNA seq datasets used for analysis in the Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention</p>
UShER performance statistics, SARS-CoV-2 daily builds 2021-2023
<p>For each day from 2021-01-07 through 2023-08-01 on which the daily build update of the UShER tree of SARS-CoV-2 genomes completed, the number of new sequences added to the tree, the number of sequences in the updated tree, the number of parallel usher jobs (original usher through 2022-04-27, usher-sampled starting 2022-04-29), the number of CPU cores per usher job, and approximate runtime of the usher batch in hours are listed. The number of sequences in the updated tree is "n/a" for most dates prior to 2021-03-11 because before that point, daily updates were for the public-sequence-only tree and the comprehensive GISAID and public sequence tree was updated only occasionally. On and after 2021-03-11, the comprehensive tree and public tree were updated daily. The runtime figures are approximate because they are calculated by subtracting the file modification date of the VCF input to usher from the file modification date of the MAT output of usher. On most days, that was a good proxy for usher runtime, but occasionally there was a crash that required debugging and/or restart, and the "runtime" includes those delays.</p>
Public sequence accessions from INSDC, COG-UK and CNCB and EPI_SET from GISAID for SARS-CoV-2 genome sequences in 2023-08-01 UShER tree
<p>Genome sequences and metadata for the accessions in the .tsv.gz (gzip-compressed tab-separated text) files are freely available from their corresponding sources:</p><ul><li>insdc.accessionNameDate.tsv.gz: INSDC (GenBank, ENA, DDBJ) sequences and metadata may be downloaded using NCBI Datasets: https://www.ncbi.nlm.nih.gov/datasets/taxonomy/2697049/ (7,361,734 accessions used on 2023-08-01)</li><li>cog.accessionNameDate.tsv.gz: COG-UK sequences and metadata may be downloaded from https://cog-uk.s3.climb.ac.uk/phylogenetics/latest (as of publication); most COG-UK sequences have been submitted to ENA and are available from INSDC/NCBI Datasets as well. (724,978 accessions used on 2023-08-01)</li><li>cncb.accessionNameDate.tsv.gz: Sequences and metadata from several databases at the China National Center for Bioinformation (CNCB) may be downloaded from GenBase: https://ngdc.cncb.ac.cn/genbase/ (26,604 accessions used on 2023-08-01)</li></ul><p>GISAID data are subject to restrictions on sharing described in https://gisaid.org/terms-of-use/. Genome sequences and metadata are available to registered GISAID users as part of EPI_SET_231106ax at https://doi.org/10.55876/gis8.231106ax (7,718,061 accessions used on 2023-08-01).</p>
Supplementary Datasets for the publication "Increased Susceptibility of Rousettus aegyptiacus Bats to Respiratory SARS-CoV-2 Challenge Despite Its Distinct Tropism for Gut Epithelia in Bats"
<p>Increasing evidence suggests bats are the ancestral hosts of the majority of coronaviruses. In gen-eral, coronaviruses primarily target the gastrointestinal system, while some strains, especially Be-tacoronaviruses with the most relevant representatives SARS-CoV, MERS-CoV, and SARS-CoV-2, also cause severe respiratory disease in humans and other mammals. We previously reported the susceptibility of Rousettus aegyptiacus (Egyptian fruit bats) to intranasal SARS-CoV-2 infection. Here, we compared their permissiveness to an oral infection versus respiratory challenge (in-tranasal or orotracheal) by assessing virus shedding, host immune responses, tissue-specific pa-thology, and physiological parameters. While respiratory challenge with a moderate infection dose of 1 × 104 TCID50 caused a systemic infection with oral and nasal shedding of replica-tion-competent virus, the oral challenge only induced nasal shedding of low levels of viral RNA. Even after a challenge with a higher infection dose of 1 × 106 TCID50, no replication-competent vi-rus was detectable in any of the samples of the orally challenged bats. We postulate that SARS-CoV-2 is inactivated by HCl and digested by pepsin in the stomach of R. aegyptiacus, thereby decreasing the efficiency of an oral infection. Therefore, fecal shedding of RNA seems to depend on systemic dissemination upon respiratory infection. These findings may influence our general understanding of the pathophysiology of coronavirus infections in bats.</p>
Observatorium serologischer Studien zu SARS-CoV-2 in Deutschland
<p>Die seit 2019 auftretende Infektionskrankheit COVID-19, hervorgerufen durch das neuartige SARS-CoV-2-Virus, führte zu gesundheitspolitischen und gesamtgesellschaftlichen Herausforderungen. Um geeignete Maßnahmen zur Eindämmung der Pandemie ergreifen zu können und neue Erkenntnisse über die Pandemie zu gewinnen, gibt es vermehrt Forschungsbedarfe zu COVID-19. Ein Ansatzpunkt hierfür sind die gewonnenen Blutproben von infizierten sowie von nicht infizierten Personen, die in Laboren auf Antikörper gegen das SARS-CoV-2-Virus getestet und analysiert werden. Sie geben Aufschluss über den Anteil der Bevölkerung, der bereits eine Infektion mit SARS-CoV-2 durchgemacht hat, und schließen dabei nicht erkannte Infektionen (Untererfassung) ein.<br>Das Projekt 'Observatorium serologischer Studien zu SARS-CoV-2 in Deutschland' (SERO-OBS Corona) gibt eine Übersicht zu Antikörper-Studien (sogenannte seroepidemiologische Studien) in Deutschland. Die seroepidemiologischen Studien basieren auf Blutproben von Bürgerinnen und Bürgern, die zu unterschiedlichen Zeitpunkten der Pandemie auf Antikörper gegen das SARS-CoV-2-Virus getestet wurden. Dabei sollen z. B. folgende Fragen beantwortet werden: Wie ist die Häufigkeit von SARS-CoV-2-Infektionen in verschiedenen Bevölkerungsgruppen? Wie hoch ist der Untererfassungsfaktor, der zeigt, wie viel Mal mehr Infektionen im Vergleich zu den bislang bekannten (gemeldeten) Fällen aufgetreten sind? In dem vorliegenden Projekt werden in Deutschland durchgeführte seroepidemiologische Studien zu SARS-CoV-2 seit dem Frühjahr 2020 über systematische Recherchen in Studienregistern, Literaturdatenbanken einschließlich Vorveröffentlichungen sowie Medienberichten fortlaufend identifizier und Studieninformationen sowie Ergebnisübersichten verfügbar gemacht.</p> <p>Die Ergebnisse des Projektes SERO-OBS-Corona werden auf der Webseite <a href="http://www.rki.de/covid-19-ak-studien">www.rki.de/covid-19-ak-studien</a>, auf Deutsch, sowie der Webseite <a href="http://www.rki.de/covid-19-serostudies-germany">www.rki.de/covid-19-serostudies-germany</a>, auf Englisch, bereitgestellt und regelmäßig aktualisiert.</p>
SMDP: SARS-CoV-2 Mutation Distribution Profiler for rapid estimation of mutational histories of unusual lineages
<p>Supplementary information relating to the manuscript titled "SMDP: SARS-CoV-2 Mutation Distribution Profiler for rapid estimation of mutational histories of unusual lineages" that has been published on the preprint server arXiv.</p> <ul> <li>PersistentInfectionScore.nb: Mathematica code used to process the data and generate Figure 2</li> <li>PersistentInfectionScore.pdf: pdf version of the above file</li> <li>Supplementary_tables_Harari_et_al_2022.xlsx: raw data from (<a href="https://www.nature.com/articles/s41591-022-01882-4#Sec19">Harari et al. 2022</a>) that was used to generate mutation distributions</li> </ul>
Terrasar measurement data of "Sar Super-Resolution Using Physics-Aware Adaptive Compressed Sensing"
<p>This data set was used to test of the method described in "Sar Super-Resolution Using Physics-Aware Adaptive Compressed Sensing". It consists of the related Terrasar data and a MATLAB file to import the data into MATLAB.</p>
Supraglacial lakes derived from Sentinel-1 SAR imagery over the Watson basin on the Greenland Ice Sheet.
<p>An experimental dataset produced for the 4D-Greenland project, one of the Polar+ projects funded by the European Space Agency. The dataset provides a classification of supraglacial lake extent, derived using Sentinel-1 SAR imagery, over the Watson case study site. The dataset is produced using a dynamic thresholding approach (Miles et al 2018). </p> <p>The dataset is produced for the period May 2017- Sept 2019. The temporal resolution of the dataset is approximately fortnightly (subject to methodological limitations) and is delivered as rasters in GeoTIFF format (epsg:3413). Raster pixels are denoted as: 0 where no surface water was detected; 1 where either HH or HV polarisation detected a backscatter signature representative of surface water; 2 where both HH and HV polarisations detected a backscatter signature representative of surface water; or 999 where the signal has been saturated and the output cannot distinguish if the signal is due to melt or other surface characteristics with the same backscattered signature. </p> <p>The naming convention indicates the original SAR tile used in the analysis and is identified by the sequence of fields described here:</p> <p><product_type>_<mission>_<mode>_<product>_<polarisation>_<starttime>_<endtime>_<orbitnumber>_<dataID>_<image>.fileextension</p> <p>For example:</p> <p>extent_S1B_EW_GRDH_1SDH_20180811T202931_20180811T203031_012220_016839_916F.tif</p>
Fastq data for Vero E6 cell infeceted with SARS CoV 2
<p>Vero cells infected with SARS-CoV 2 and the transcriptome sequenced by dRNAseq on nanopore.</p>
Genome-wide structure and function modeling of SARS-COV-2
<p>Homology models and function annotation for all proteins in the SARS-CoV-2 genome. For a description of each file, follow <a href="https://zhanglab.ccmb.med.umich.edu/COVID-19/">this link</a>. </p>
SIRAH-CoV2 initiative: co-factor complex of NSP7 and the C-terminal domain of NSP8 from SARS CoV-2 (PDBid:6WIQ)
<p>This dataset contains the trajectory of a 10 microseconds-long coarse-grained molecular dynamics simulation of the co-factor complex of NSP7 and the C-terminal domain of NSP8 from SARS CoV-2 (PDBid:6WIQ). Simulations have been performed using the SIRAH force field running with the Amber18 package at the Uruguayan National Center for Supercomputing (ClusterUY) under the conditions reported in <a href="https://pubs.acs.org/doi/10.1021/acs.jctc.9b00006">Machado et al. JCTC 2019</a>, adding 150 mM NaCl according to <a href="https://pubs.acs.org/doi/10.1021/acs.jctc.9b00953">Machado & Pantano JCTC 2020</a>. </p> <p>The files 6WIQ_SIRAHcg_rawdata_0-5us.tar, and 6WIQ_SIRAHcg_rawdata_5-10us.tar, contain all the raw information required to visualize (on VMD), analyze, backmap, and eventually continue the simulations using Amber18 or higher. Step-By-Step tutorials for running, visualizing, and analyzing CG trajectories using <a href="https://academic.oup.com/bioinformatics/article/32/10/1568/1743152">SirahTools</a> can be found at www.sirahff.com.</p> <p>Additionally, the file 6WIQ_SIRAHcg_10us_prot.tar contains only the protein coordinates, while 6WIQ_SIRAHcg_10us_prot_skip10ns.tar contains one frame every 10ns.</p> <p>To take a quick look at the trajectory:</p> <p>1- Untar the file 6WIQ_SIRAHcg_10us_prot_skip10ns.tar</p> <p>2- Open the trajectory on VMD using the command line:</p> <p>vmd 6WIQ_SIRAHcg_prot.prmtop 6WIQ_SIRAHcg_prot.ncrst 6WIQ_SIRAHcg_10us_prot_skip10ns.nc -e sirah_vmdtk.tcl</p> <p>Note that you can use normal VMD drawing methods as vdw, licorice, etc., and coloring by restype, element, name, etc. </p> <p>This dataset is part of the SIRAH-CoV2 initiative.</p> <p>For further details, please contact Florencia Klein (fklein@pasteur.edu.uy) or Sergio Pantano (spantano@pasteur.edu.uy).</p>
All-atom 500-nano seconds Molecular Dynamics Simulations of SARS-CoV-2 Spike Receptor-binding Domain bound with ACE2
<p>Data includes all of the trajectories (1000) of classical all-atom molecular dynamics (MD) simulations of of SARS-CoV2 Spike Protein/ACE2 complex (PDB ID: 6M0J). In order to decrease the size of the file only protein rajectories were provided. Simulation has been performed with Desmond. Protein was placed in the cubic boxes with explicit TIP3P water models that have 10.0 Å thickness from surfaces of protein. The system is neutralized by adding counter ions, and salt solution of 0.15M NaCl was also used to adjust the concentration of the systems. The long-range electrostatic interactions were calculated by the particle mesh Ewald method. A cutoff radius of 9.0 Å was used for both van der Waals and Coulombic interactions. The temperature was set as 310K initially, and Nose–Hoover thermostat was used for adjustment. Martyna–Tobias–Klein protocol was employed to control the pressure, which was set at 1.01325 bar. The time-step was assigned as 2.0 fs. The default values were used for minimization and equilibration steps, and finally 500 nano-seconds (ns) production run was performed for the simulation.</p>
Dynamics of SARS-CoV-2 spike protein in open and closed states and identification of key structural perturbations upon mutations
<p>The SARS-Cov-2 spike protein resides on the exterior surface of the coronavirus, and therefore, acts as the first point of contact that mediates cell attachment and fusion. During this process, it undergoes dramatic conformational changes upon host receptor binding. We are leveraging high-performance computing to identify these structural perturbations in wildtype and mutant spike protein models. The files contain structures from molecular dynamics simulations of closed SARS-Cov-2 spike protein embedded in POPC membrane.</p>
Data and code for the analysis in "Assessing the impact of non-pharmaceutical interventions on SARS-CoV-2 transmission in Switzerland"
<p>Data and code used for the analysis in <em>Assessing the impact of non-pharmaceutical interventions on SARS-CoV-2 transmission in Switzerland</em> (Lemaitre et al., Swiss Medial Weekly 2020).</p>
SARS-COV2 Spike Glycopeptide Mass-Retention Time PCDL database
<p>Contains accurate mass, HPLC retention time, peptide sequence, glycan structure and mass spectra for over 400 glycopeptides from elastase digestion of SARS-COV2 Spike antigen and receptor binding domain. The database is used as part of the Mass-Retention Time Fingerprinting method to characterise Spike glycans as described in the BioRxiv preprint “Identification, Mapping and Relative Quantitation of SARS-Cov2 Spike Glycopeptides by Mass-Retention Time Fingerprinting”</p>
SARS-CoV-2 main protease 3D print model
<p>A 3D model for printing SARS-CoV-2 main protease from our paper on FAIR sharing molecular visualization experiences.</p>
Simulation results for Sars-CoV2 3C-like main protease: TRAPP analysis of the binding site flexibility and results of the docking study
<p>Collection of data and scripts related to the paper:</p> <p>Jonas Gossen et al. "A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics" </p> <p>https://www.biorxiv.org/content/10.1101/2020.12.14.422634v2 doi: https://doi.org/10.1101/2020.12.14.422634</p> <p>ACS Pharmacology and Translational Science 2021 DOI: 10.1021/acsptsci.0c00215</p> <p> </p> <p> </p> <p><strong>1. TRAPP simulation results for Sars-CoV2 3C-like main protease:</strong></p> <p>include simulation of the binding pocket druggability, physical-chemical properties, and the binding site composition</p> <p><a href="https://zenodo.org/api/files/f6c0a0ae-d53a-4e78-aaaf-b3ff674171a5/Protease_clean.ipynb">Protease_clean.ipynb</a> - Jupyter Notebook containing analysis of the generated data</p> <p><a href="https://zenodo.org/api/files/f6c0a0ae-d53a-4e78-aaaf-b3ff674171a5/allTables.zip">allTables.zip</a> - results of TRAPP simulations of the binding site flexibility using LRIP and tConcoord methods</p> <p><a href="https://zenodo.org/api/files/f6c0a0ae-d53a-4e78-aaaf-b3ff674171a5/Every10-ligand_6LU7_R3.5.zip">Every10-ligand_6LU7_R3.5.zip</a> - results of TRAPP pocket analysis on the MD frames</p> <p><a href="https://zenodo.org/api/files/f6c0a0ae-d53a-4e78-aaaf-b3ff674171a5/PDB-Giulia.zip">PDB-Giulia.zip</a> - TRAPP pocket analysis of 40 PDB complexes of main protease</p> <p><a href="https://zenodo.org/api/files/f6c0a0ae-d53a-4e78-aaaf-b3ff674171a5/TRAPP_properties_PDB.xlsx">TRAPP_properties_PDB.xlsx</a> - binding pocket properties for 40 PDB complexes of main protease summarized in a table</p> <p><a href="https://zenodo.org/api/files/f6c0a0ae-d53a-4e78-aaaf-b3ff674171a5/DrugPDB_3structures.xlsx">DrugPDB_3structures.xlsx</a> - binding pocket properties for 3 PDB structures </p> <p><strong>2. Docking & Screening Results</strong></p> <p><a href="https://zenodo.org/api/files/9165535d-aec5-4f1e-8ad1-6ca11a90e595/TRAPP_secondSelection_VS.csv">TRAPP_secondSelection_VS.csv</a> - docking/screening of selected structures from TRAPP analysis</p> <p><a href="https://zenodo.org/api/files/9165535d-aec5-4f1e-8ad1-6ca11a90e595/Fred_VS.csv">Fred_VS.csv</a> - docking of PDB structures using Fred</p> <p><a href="https://zenodo.org/api/files/9165535d-aec5-4f1e-8ad1-6ca11a90e595/Glide_VS.csv">Glide_VS.csv</a> - docking of PDB structures using Glide</p> <p><a href="https://zenodo.org/api/files/77b1679d-ccc9-4e30-add2-5f7420e04ed1/TableS1.xlsx">TableS1.xlsx</a> - Available structures of SARS-CoV-2 Mpro selected for binding site analyses. </p> <p><a href="https://zenodo.org/api/files/77b1679d-ccc9-4e30-add2-5f7420e04ed1/TableS2A.xlsx">TableS2A.xlsx</a> - SiteScore analysis of all the deposited X-ray crystal structures for the Mpro.</p> <p><a href="https://zenodo.org/api/files/77b1679d-ccc9-4e30-add2-5f7420e04ed1/TableS2B.xlsx">TableS2B.xlsx</a> - SiteScore analysis of the MSM ensemble (4-macrostates).</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.