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12 results for “SEIZURE OUTCOME”
A Factor Analysis Model for Dimension Reduction of Outcome Factors in Neonatal Seizure Context-Figure 2. Identified risk factors hierarchy
<p>AED - antiepileptic drug, CP - cerebral palsy, GDD - global developmental delay, GA - gestational age, BW- birth weight, RS - repeated/recurrent seizure, MD - type/mode of delivery, AS1 - Apgar score at 1 minute, AS5 - Apgar score at 5 minute, AS10 - Apgar score at 10 minute, SO - seizure onset, ST_EPI - status epilepticus, UBS - ultrasound brain scan, MSU- maternal substance used, MIS – maternal inflammatory state, PRM- prolonged rupture of membranes, PNN – postnatal neuroimaging, PNS – postnatal seizure. The most frequently identified risk factors were the EEG findings (abnormal / severe electroencephalogram results), seizure characteristics (type, onset, duration, semiology), etiology, birth weight, Apgar score, cerebral ultrasound scan findings (abnormal) (Figure 2).</p>
A Factor Analysis Model for Dimension Reduction of Outcome Factors in Neonatal Seizure Context-A Factor Analysis Model for Dimension Reduction of Outcome Factors in Neonatal Seizure Context
<p>R retrospective, P prospective, CC case – control study, MC multicenter controlled trail, PB populational based, HB hospital based, C clinical, CT computed tomographic scan, MRI cerebral magnetic resonance imaging, CUS cranial ultrasonography / cerebral ultrasound, USG ultrasonography, EEG electroencephalogram (standard), CpH cord Ph, BpH blood Ph, HT therapeutic hypothermia It can be noticed that seizure diagnosis was based on clinical grounds and functional explorations naming neuroimaging and/or EEG procedures (conventional EEG, aEEG, vEEG, CUS, MRI). The minimum number of newborns considered in these studies was 55, while the maximum was 403 with a mean of 148 (SD=86.75, median=112, IQR: (98,175)) and a total of 2226 evaluated cases.</p>
Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery
<p>iEEGnetworksFC: Functional Connectivity Networks</p> <p>iEEGnetworkSCPre: Structural Connectivity Networks before surgery</p> <p>iEEGnetworkSCPost: Structural Connectivity Networks expected after surgery</p> <p>iEEGnetworkSCPre5mm: Structural Connectivity Networks before surgery with alternate ROI size of 5mm at each contact</p> <p> </p>
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy
ClinicalTrials.gov study NCT03590197. IPD Sharing: UNDECIDED. Countries: 1. Publications: 32.
Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
ClinicalTrials.gov study NCT03419260. IPD Sharing: NO. Countries: 1. Publications: 10.
Seizure outcome of pediatric epilepsy surgery: systematic review and meta-analyses
<p><b>Objective:</b> This systematic review and meta-analyses assessed seizure outcome following pediatric epilepsy surgery.</p> <p><b>Methods: </b>MEDLINE, Embase and Cochrane were searched for pediatric epilepsy surgery original research from 1990 to 2017. The outcome was seizure freedom at 12 months or longer follow-up. Using random effects models, the effect sizes for controlled studies, uncontrolled studies on surgery locations (temporal lobe [TL], extra-temporal lobe [ETL] or hemispheric surgery), pathologies, non-lesional epilepsy and incomplete resection were estimated. Meta-regression assessed the relationship between age at surgery, age at seizure onset and seizure outcome. Random-effects network meta-analysis was conducted for surgery locations.</p> <p><b>Results:</b> 258 studies were included. Surgery achieved higher seizure freedom than medical therapy (OR=6.49 [95%CI: 2.87, 14.70], p<0.001). Seizure freedom declined over time after surgery, from 64.8% (95%CI: 51.2%, 76.4%; p=0.034) at 1 year, to 60.3% (95%CI: 52.9%, 67.4%; p=0.007) at 5 years, and 39.7% (95%CI: 28.4%, 52.2%, p=0.106) at 10 years. Seizure freedom was (i) highest for hemispheric surgery, followed by TL, and ETL surgery; and (ii) highest for tumor, and lower for malformations of cortical development. Seizure freedom was lower for non-lesional than lesional epilepsy (OR=0.54 [95%CI: 0.34, 0.88], p=0.013), and incomplete than complete resection (OR=0.13 [95%CI: 0.08, 0.21], p<0.001). Age at surgery and age at seizure onset were associated with seizure freedom for mixed pathologies and surgery locations, and TL surgery.</p> <p><b>Conclusion:</b> Epilepsy surgery was more effective than medical therapy to control seizures. Understanding seizure outcomes of different surgery locations, pathologies, non-lesional epilepsy and incomplete resection will assist with pre-surgical counselling.</p>
VNS and seizure outcomes in pediatric refractory epilepsy: Systematic review and meta-analysis
<p>This data provides supplemental information for the systematic review and Meta-analysis. Supplemental tables report the detailed serach strategy (Supplementary Table <span><span><span><span><span><span><span><span><span>1), details of included studies (</span></span></span></span></span></span></span></span></span>Supplementary Table <span><span><span><span><span><span><span><span><span>2), list of excluded studies (</span></span></span></span></span></span></span></span></span>Supplementary Table <span><span><span><span><span><span><span><span><span>3), 50% Responder Rate in children with Lennox-Gastaut syndrome after VNS insertion (</span></span></span></span></span></span></span></span></span>Supplementary Table <span><span><span><span><span><span><span><span><span>4), 50% Responder Rate in children with Dravet syndrome after VNS insertion (</span></span></span></span></span></span></span></span></span>Supplementary Table 5<span><span><span><span><span><span><span><span><span>), VNS settings and other seizure outcomes reported in the included studies (</span></span></span></span></span></span></span></span></span>Supplementary Table 6<span><span><span><span><span><span><span><span><span>) and Studies reporting a formal Quality of life (QOL) assessment in children post VNS implantation (</span></span></span></span></span></span></span></span></span>Supplementary Table 7<span><span><span><span><span><span><span><span><span>). </span></span></span></span></span></span></span></span></span></p> <p><b>Supplemental figure 1 </b><strong>(S1)</strong> shows the PRISMA flowchart for this systematic review. </p> <p><strong>Supplemental Figure 2</strong><span><span><span><span><span><span><span><span><span> <strong>(S2)</strong>: </span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span>Determinants of Seizure Outcomes. Multivariable regression showed 50%-RR at last reported follow-up to increase with increasing age of onset of seizures and decrease with the number of ASMs tried before VNS implantation (A). Higher 50%-RR 1-year after VNS implantation was seen in patients with shorter duration of epilepsy and fewer number of ASM trials (B). Decline in 50%-RR at 1 and 2 year follow-up in studies with a higher proportion of males (C). Proportion of seizure free patients at last reported follow-up also decreases with a greater number of ASM trials before VNS implantation (D). [50%-RR: 50% Responder Rate, ASM: Anti-seizure Medication, VNS: Vagus Nerve Stimulator; Bubbles represent individual effect size for studies, lines represent ordinary least squares regression models, and<a name="_Hlk61802391"> </a>the shading represents 95% confidence regions.</span></span></span></span></span></span></span></span></span></p> <p><strong>Supplemental figure 3 (S3)</strong>: <span>Forest plots for proportion of seizure free patients. </span><span><span><span><span><span><span><span><span><span>Forest plots for proportion of patients with 50% responder rate at 6 months (B), 1 year (C) and 2 years (D) follow-up summarizing the pooled effect estimate and heterogeneity. </span></span></span></span></span></span></span></span></span></p> <p><strong>Supplemental figure 4 (S4)</strong>: <span>Forest plots for proportion of seizure free patients. </span><span><span><span><span><span><span><span><span><span>Forest plots for proportion of seizure free patients at 6 months (B), 1 year (C) and 2 years (D) follow-up summarizing the pooled effect estimate and heterogeneity.</span></span></span></span></span></span></span></span></span></p>
Seizure and Anatomical Outcomes of Repeat Laser Amygdalohippocampotomy for Temporal Lobe Epilepsy: A Single-Institution Case Series
<p>Subject imaging data.</p>
VNS and seizure outcomes in pediatric refractory epilepsy: Systematic review and meta-analysis
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Seizure outcome of pediatric epilepsy surgery: systematic review and meta-analyses
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Data from: Epilepsy duration and seizure outcome in epilepsy surgery: a systematic review and meta-analysis
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Biomarkers In Seizure To Predict Recurrence and Severe Outcomes
ClinicalTrials.gov study NCT01774500. IPD Sharing: Not stated. Countries: 2. Publications: 0.
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