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6 results for “SGS1”
Data from: Controlling meiotic recombinational repair: specifying the roles of ZMMs, Sgs1 and Mus81/Mms4 in crossover formation
Crossovers (COs) play a critical role in ensuring proper alignment and segregation of homologous chromosomes during meiosis. How the cell balances recombination between CO vs. noncrossover (NCO) outcomes is not completely understood. Further lacking is what constrains the extent of DNA repair such that multiple events do not arise from a single double-strand break (DSB). Here, by interpreting signatures that result from recombination genome-wide, we find that synaptonemal complex proteins promote crossing over in distinct ways. Our results suggest that Zip3 (RNF212) promotes biased cutting of the double Holliday-junction (dHJ) intermediate whereas surprisingly Msh4 does not. Moreover, detailed examination of conversion tracts in sgs1 and mms4-md mutants reveal distinct aberrant recombination events involving multiple chromatid invasions. In sgs1 mutants, these multiple invasions are generally multichromatid involving 3–4 chromatids; in mms4-md mutants the multiple invasions preferentially resolve into one or two chromatids. Our analysis suggests that Mus81/Mms4 (Eme1), rather than just being a minor resolvase for COs is crucial for both COs and NCOs in preventing chromosome entanglements by removing 3′- flaps to promote second-end capture. Together our results force a reevaluation of how key recombination enzymes collaborate to specify the outcome of meiotic DNA repair.
Data from: Controlling meiotic recombinational repair: specifying the roles of ZMMs, Sgs1 and Mus81/Mms4 in crossover formation
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Data from: "Blood transcriptome sequencing of Common Crossbills (Loxia curvirostra) experimentally infected by the avian malaria parasite Plasmodium relictum (lineage SGS1)" in Genomic Resources Notes accepted 1 June 2013-31 July 2013
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Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
GEO Series GSE147452. Saccharomyces cerevisiae. 22 samples. Type: Genome binding/occupancy profiling by genome tiling array.
The expression profiles of WT and sgs1△ after tangeretin treatment
GEO Series GSE43799. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by array.
SGS1 synthetic lethality
GEO Series GSE1757. Saccharomyces cerevisiae. 5 samples. Type: Expression profiling by array.
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