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220 results for “SMA”
SMA-TB Clinical trial: video & electronic informed consent
<p>The first SMA-TB video has been produced aiming a better understanding of SMA-TB Randomized Clinical Trial (RCT) objectives and procedures. This RCT is work package 1 of SMA-TB project. It is entitled <em>"Phase 2b Randomized double-blind, placebo controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen (SMA-TB)”, </em>and is registered in ClinicalTrials.gov data under identifier NCT04575519</p> <p>This video has been conceptualized as an e-informed consent for TB patients aiming their participation in SMA-TB CTs in Georgia and South Africa, as well as for anyone wanting to learn about the SMA-TB CT. The video explains in a very comprehensive way the rationale of SMA-TB concept, how the CT will be performed, what is expected from the patient, which are potential benefits, as well as side effects. The message is produced both in English and in Georgian.</p>
Data to publication: Fibre optic measurements and model uncertainty quantification for Fe-SMA strengthened concrete structures
<p>This dataset contains the results of an experimental campaign, presented in the publication "Fibre optic measurements and model uncertainty quantification for Fe-SMA strengthened concrete structures". The publication covers fibre optic measurements inside large-scale specimens subjected to external load. The specimens comprised reinforced concrete slabs, strengthened with reinforcement bars made from iron-based shape memory alloy.</p>
REsolved ALMA and SMA Observations of Nearby Stars (REASONS)
<p>This is the data release of the REASONS survey, a sample of planetesimal belts around nearby stars resolved interferometrically (see journal article for full details). Every tar file corresponds to a planetary system, and contains:<br>Data:<br>1 - the calibrated continuum visibility data in CASA .ms format<br>2 - a FITS file with the non-primary-beam-corrected image of the system. <br>3 - a PDF image of the system<br>Visibility modelling results:<br>4 - an ASCII file ('*_fitresults.txt') containing the results of the MCMC visibility fitting, as reported in Table X in the article but containing extra parameters fitted (such as background sources, extra astrometry for fits of multiple datasets/pointings, weight-rescaling factors)<br>5 - an ASCII notes ('*_fitnotes.txt') file, which should always be consulted when interpreting the fit results, as it typically points out peculiarities in the posterior probability distributions.<br>6 - a PDF of the triangle ('corner') plot of the N-dimensional posterior probability distribution of the fitted parameters, which should be consulted to get a better idea of the results reported in the ASCII files.<br>7 - a PDF image (targetstar_imagecombo.pdf) showing the data, model, residuals and visibility data+model curves, to visually evaluate the goodness of the visibility fit.<br>8 - a PDF image (targetstar.pdf) showing the multiwavelength photometry for the planetary system and a star+belt modified-blackbody fit, with parameters reported in the journal article.<br>Please refer to the journal article for more details on the methods used to obtain these data and modelling results.</p>
Dataset for: DECaPS and SMA discovery of a highly-inclined class I YSO with an outflow: IRAS 08235-4316
<p>This repository provides the dataset for the paper "DECaPS and SMA discovery of a highly-inclined class I YSO with an outflow: IRAS 08235-4316" by Joshua Bennett Lovell et al. It is associated with manuscript number AJ AAS57883.</p> <p>All data and code for the project stored here.</p> <p>A jupyter notebook file is included which provides the script to reproduce all presented figures in the paper.</p> <p>A set of .fits extension files are provided, which include the SMA 12CO cube, associated moment map images, the SMA continuum image, and the DECaPS RGB cube.</p>
SMA TB Clinical trial - Soweto site - Short story
<p>In this video a nurse from SMA-TB clinical trial research team from South Africa shows one working day from Soweto, Baragwanath Hospital. She also gives insight about challenges of running a clinical trial during the COVID-19 pandemic. </p> <p>SMA-TB project has received funding from the European Union's Horizon 2020 research and innovation programme under grant ageement No 847762.</p>
SMA-TB Clinical trial research team's thoughts and opinions
<p>In this video SMA-TB Clinical trial research team members from Georgia and South Africa share their thoughts and opinions regarding the SMA-TB project and its impact both at scientific and personal level. </p> <p>SMA-TB team comprises of doctors, nurses, laboratory technicians and administrative. This video gives opportunity to look at and think of SMA-TB project from different perspectives. </p> <p>SMA-TB project has received funding from the European Union's Horizon 2020 research and innovation programme under grant ageement No 847762</p>
Dataset related to article "SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples"
<p>mice survival after treatment with anti-miR-181a-5p; mice weight after treatment with anti-miR-324-5p</p>
P10 2B/- SMA Mice Righting Reflex
<p> </p> <p><strong>Supplemental Video 1:</strong> Righting reflex of control and Smn<sup>2B/-</sup> mice at P10.</p> <p><strong>DOI:</strong> 10.1152/jn.00652.2018</p> <p><strong>Hyperexcitability precedes motoneuron loss in the Smn<sup>2B/-</sup> mouse model of spinal muscular atrophy.</strong></p> <p>Quinlan KA<sup>1*</sup>, Reedich E<sup>2*</sup>, Arnold WD<sup>3</sup>, Puritz A<sup>4</sup>, Cavarsan CF<sup>1</sup>, Heckman CJ<sup>5</sup>, DiDonato CJ<sup>6</sup>.</p> <p>*These authors contributed equally to this work. </p> <p>1 Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, United States.</p> <p>2 Lurie Childrens/Northwestern Univ., United States.</p> <p>3 The Ohio State University, United States.</p> <p>4 Northwestern University, United States.</p> <p>5 Physiology, Physical Medicine and Rehabilitation, Physical Therapy and Human Movement Sciences, Northwestern University, United States.</p> <p>6 Lurie Children's Hospital, United States.</p>
Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or Ris
ClinicalTrials.gov study NCT05386680. IPD Sharing: YES. Countries: 9. Publications: 1.
An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)
ClinicalTrials.gov study NCT02268552. IPD Sharing: UNDECIDED. Countries: 7. Publications: 1.
Efficacy and Safety of Intrathecal OAV101 (AVXS-101) in Pediatric Patients With Type 2 Spinal Muscular Atrophy (SMA)
ClinicalTrials.gov study NCT05089656. IPD Sharing: YES. Countries: 13. Publications: 1.
Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA)
ClinicalTrials.gov study NCT04851873. IPD Sharing: YES. Countries: 9. Publications: 1.
Pre-Symptomatic Study of Intravenous Onasemnogene Abeparvovec-xioi in Spinal Muscular Atrophy (SMA) for Patients With Multiple Copies of SMN2
ClinicalTrials.gov study NCT03505099. IPD Sharing: YES. Countries: 6. Publications: 3.
Continuum u-v tables for NGC 1333 IRAS 2A (PdBI, 203 GHz), NGC 1333 IRAS 4A (SMA, 335), NGC 1333 IRAS 4B (PdBI, 203), and VLA 1623 (ALMA, 219)
<p>This archive is currently hosted at zenodo.com by Magnus Persson. If <br /> you downloaded it from elsewhere, please send me an <br /> email (magnusp@vilhelm.nu).</p> <p>This data was observed at the IRAM Plateau de Bure Interferometer <br /> (now NOEMA), Atacama Large (sub-)Millimeter Array (ALMA) and <br /> SubMillimter Array (SMA). Any publication arising from this data <br /> should have the appropriate notice that is provided by the <br /> instititue in question (see http://iram.fr, http://almascience.org <br /> or http://sma1.sma.hawaii.edu/).</p> <p>The data is provided as is, however, with this data it is possible <br /> to reproduce the results presented in the paper(s) : "Constraining <br /> the physical structure of the inner few 100 AU scales of <br /> deeply-embedded low-mass protostars.", Authors: M. V. Persson, D. <br /> Harsono, J. J. Tobin, E. F. van Dishoeck, J. K. Jørgensen, N. <br /> Murillo, and S.-P. Lai, journal Astronomy & Astrohpysics</p> <p><br /> This dataset currently contains the continuum subtracted UV-tables, <br /> in UVFITS format written by GILDAS MAPPING for the sources NGC 1333 <br /> IRAS 2A (203 GHz), NGC 1333 IRAS 4A (335), NGC 1333 IRAS 4B (203), <br /> and VLA 1623 (219).</p> <p> </p>
REsolved ALMA and SMA Observations of Nearby Stars (REASONS): Observation Logs
<p>Observation Details for millimetre-wavelength data gathered and modelled as part of the REsolved ALMA and SMA Observations of Nearby Stars (REASONS) paper (same DOI as this table). For the processed data and modelling results, see https://doi.org/10.5281/zenodo.12583396.</p> <ul> <li>Table A.1 refers to targets observed as part of the REASONS <em>Observational</em> ALMA program</li> <li>Table A.2 refers to targets observed as part of the REASONS <em>Observational</em> SMA program</li> <li>Table A.3 refers to targets previously observed whose raw data was retrieved from the ALMA archive and reanalysed as part of REASONS.</li> </ul>
CB491 sma-3(e491)III | 2011-09-22T12:28:59+01:00
<blockquote> <p>This experiment is part of the <em>C.elegans behavioural database</em>. For more information and the complete collection of experiments visit http://movement.openworm.org</p> </blockquote> <ul> <li><b>preview link</b> : https://www.youtube.com/watch?v=9189l-nhcos</li> <li><b>strain</b> : CB491</li> <li><b>timestamp</b> : 2011-09-22T12:28:59+01:00</li> <li><b>gene</b> : sma-3</li> <li><b>chromosome</b> : III</li> <li><b>allele</b> : e491</li> <li><b>strain_description</b> : sma-3(e491)III</li> <li><b>sex</b> : hermaphrodite</li> <li><b>stage</b> : adult</li> <li><b>ventral_side</b> : clockwise</li> <li><b>media</b> : NGM agar low peptone</li> <li><b>arena</b> : <ul> <li><b>style</b> : petri</li> <li><b>size</b> : 35</li> <li><b>orientation</b> : away</li> </ul> </li> <li><b>food</b> : OP50</li> <li><b>habituation</b> : 30m wait</li> <li><b>who</b> : Laura Grundy</li> <li><b>protocol</b> : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li><b>lab</b> : <ul> <li><b>name</b> : William R Schafer</li> <li><b>location</b> : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li><b>software</b> : <ul> <li><b>name</b> : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li><b>version</b> : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li><b>featureID</b> : @OMG</li> </ul> </li> <li><b>base_name</b> : sma-3 (e491)III on food L_2011_09_22__12_28_59___1___5</li> <li><b>total time (s)</b> : 899.0</li> <li><b>frames per second</b> : 30.03</li> <li><b>video micrometers per pixel</b> : 4.44972</li> <li><b>number of segmented skeletons</b> : 24413</li> </ul>
CB502 sma-2(e502)III | 2011-10-18T15:42:56+01:00
<blockquote> <p>This experiment is part of the <em>C.elegans behavioural database</em>. For more information and the complete collection of experiments visit http://movement.openworm.org</p> </blockquote> <ul> <li><b>preview link</b> : https://www.youtube.com/watch?v=l-d1zx2aGik</li> <li><b>strain</b> : CB502</li> <li><b>timestamp</b> : 2011-10-18T15:42:56+01:00</li> <li><b>gene</b> : sma-2</li> <li><b>chromosome</b> : III</li> <li><b>allele</b> : e502</li> <li><b>strain_description</b> : sma-2(e502)III</li> <li><b>sex</b> : hermaphrodite</li> <li><b>stage</b> : adult</li> <li><b>ventral_side</b> : clockwise</li> <li><b>media</b> : NGM agar low peptone</li> <li><b>arena</b> : <ul> <li><b>style</b> : petri</li> <li><b>size</b> : 35</li> <li><b>orientation</b> : away</li> </ul> </li> <li><b>food</b> : OP50</li> <li><b>habituation</b> : 30m wait</li> <li><b>who</b> : Laura Grundy</li> <li><b>protocol</b> : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li><b>lab</b> : <ul> <li><b>name</b> : William R Schafer</li> <li><b>location</b> : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li><b>software</b> : <ul> <li><b>name</b> : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li><b>version</b> : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li><b>featureID</b> : @OMG</li> </ul> </li> <li><b>base_name</b> : sma-2 (e502) on food L_2011_10_18__15_42_56___8___10</li> <li><b>total time (s)</b> : 898.967</li> <li><b>frames per second</b> : 30.03</li> <li><b>video micrometers per pixel</b> : 4.9828</li> <li><b>number of segmented skeletons</b> : 26997</li> </ul>
CB491 sma-3(e491)III | 2011-09-20T11:43:06+01:00
<blockquote> <p>This experiment is part of the <em>C.elegans behavioural database</em>. For more information and the complete collection of experiments visit http://movement.openworm.org</p> </blockquote> <ul> <li><b>preview link</b> : https://www.youtube.com/watch?v=ztiKN7GIjfk</li> <li><b>strain</b> : CB491</li> <li><b>timestamp</b> : 2011-09-20T11:43:06+01:00</li> <li><b>gene</b> : sma-3</li> <li><b>chromosome</b> : III</li> <li><b>allele</b> : e491</li> <li><b>strain_description</b> : sma-3(e491)III</li> <li><b>sex</b> : hermaphrodite</li> <li><b>stage</b> : adult</li> <li><b>ventral_side</b> : anticlockwise</li> <li><b>media</b> : NGM agar low peptone</li> <li><b>arena</b> : <ul> <li><b>style</b> : petri</li> <li><b>size</b> : 35</li> <li><b>orientation</b> : away</li> </ul> </li> <li><b>food</b> : OP50</li> <li><b>habituation</b> : 30m wait</li> <li><b>who</b> : Laura Grundy</li> <li><b>protocol</b> : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li><b>lab</b> : <ul> <li><b>name</b> : William R Schafer</li> <li><b>location</b> : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li><b>software</b> : <ul> <li><b>name</b> : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li><b>version</b> : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li><b>featureID</b> : @OMG</li> </ul> </li> <li><b>base_name</b> : sma-3 (e491)III on food R_2011_09_20__11_43_06___8___2</li> <li><b>total time (s)</b> : 898.967</li> <li><b>frames per second</b> : 30.03</li> <li><b>video micrometers per pixel</b> : 4.99919</li> <li><b>number of segmented skeletons</b> : 26816</li> </ul>
CB491 sma-3(e491)III | 2011-09-22T11:12:19+01:00
<blockquote> <p>This experiment is part of the <em>C.elegans behavioural database</em>. For more information and the complete collection of experiments visit http://movement.openworm.org</p> </blockquote> <ul> <li><b>preview link</b> : https://www.youtube.com/watch?v=j9sLwfom194</li> <li><b>strain</b> : CB491</li> <li><b>timestamp</b> : 2011-09-22T11:12:19+01:00</li> <li><b>gene</b> : sma-3</li> <li><b>chromosome</b> : III</li> <li><b>allele</b> : e491</li> <li><b>strain_description</b> : sma-3(e491)III</li> <li><b>sex</b> : hermaphrodite</li> <li><b>stage</b> : adult</li> <li><b>ventral_side</b> : anticlockwise</li> <li><b>media</b> : NGM agar low peptone</li> <li><b>arena</b> : <ul> <li><b>style</b> : petri</li> <li><b>size</b> : 35</li> <li><b>orientation</b> : away</li> </ul> </li> <li><b>food</b> : OP50</li> <li><b>habituation</b> : 30m wait</li> <li><b>who</b> : Laura Grundy</li> <li><b>protocol</b> : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li><b>lab</b> : <ul> <li><b>name</b> : William R Schafer</li> <li><b>location</b> : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li><b>software</b> : <ul> <li><b>name</b> : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li><b>version</b> : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li><b>featureID</b> : @OMG</li> </ul> </li> <li><b>base_name</b> : sma-3 (e491)III on food R_2011_09_22__11_12_19___8___1</li> <li><b>total time (s)</b> : 898.967</li> <li><b>frames per second</b> : 30.03</li> <li><b>video micrometers per pixel</b> : 4.99919</li> <li><b>number of segmented skeletons</b> : 26997</li> </ul>
CB502 sma-2(e502)III | 2011-10-06T12:15:29+01:00
<blockquote> <p>This experiment is part of the <em>C.elegans behavioural database</em>. For more information and the complete collection of experiments visit http://movement.openworm.org</p> </blockquote> <ul> <li><b>preview link</b> : https://www.youtube.com/watch?v=CgaxziW1NpA</li> <li><b>strain</b> : CB502</li> <li><b>timestamp</b> : 2011-10-06T12:15:29+01:00</li> <li><b>gene</b> : sma-2</li> <li><b>chromosome</b> : III</li> <li><b>allele</b> : e502</li> <li><b>strain_description</b> : sma-2(e502)III</li> <li><b>sex</b> : hermaphrodite</li> <li><b>stage</b> : adult</li> <li><b>ventral_side</b> : clockwise</li> <li><b>media</b> : NGM agar low peptone</li> <li><b>arena</b> : <ul> <li><b>style</b> : petri</li> <li><b>size</b> : 35</li> <li><b>orientation</b> : away</li> </ul> </li> <li><b>food</b> : OP50</li> <li><b>habituation</b> : 30m wait</li> <li><b>who</b> : Laura Grundy</li> <li><b>protocol</b> : Method in E. Yemini et al. doi:10.1038/nmeth.2560. Worm transferred to arena 30 minutes before recording starts.</li> <li><b>lab</b> : <ul> <li><b>name</b> : William R Schafer</li> <li><b>location</b> : MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK</li> </ul> </li> <li><b>software</b> : <ul> <li><b>name</b> : tierpsy (https://github.com/ver228/tierpsy-tracker)</li> <li><b>version</b> : cbfc23eb4f1ac2f29be75ade7a937eed58a5b219</li> <li><b>featureID</b> : @OMG</li> </ul> </li> <li><b>base_name</b> : sma-2 (e502)III on food L_2011_10_06__12_15_29__5</li> <li><b>total time (s)</b> : 898.967</li> <li><b>frames per second</b> : 30.03</li> <li><b>video micrometers per pixel</b> : 3.9146</li> <li><b>number of segmented skeletons</b> : 26750</li> </ul>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.