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10 results for “SOS response”
Data from: The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic
Exposure to antibiotics induces the expression of mutagenic bacterial stress–response pathways, but the evolutionary benefits of these responses remain unclear. One possibility is that stress–response pathways provide a short-term advantage by protecting bacteria against the toxic effects of antibiotics. Second, it is possible that stress-induced mutagenesis provides a long-term advantage by accelerating the evolution of resistance. Here, we directly measure the contribution of the Pseudomonas aeruginosa SOS pathway to bacterial fitness and evolvability in the presence of sublethal doses of ciprofloxacin. Using short-term competition experiments, we demonstrate that the SOS pathway increases competitive fitness in the presence of ciprofloxacin. Continued exposure to ciprofloxacin results in the rapid evolution of increased fitness and antibiotic resistance, but we find no evidence that SOS-induced mutagenesis accelerates the rate of adaptation to ciprofloxacin during a 200 generation selection experiment. Intriguingly, we find that the expression of the SOS pathway decreases during adaptation to ciprofloxacin, and this helps to explain why this pathway does not increase long-term evolvability. Furthermore, we argue that the SOS pathway fails to accelerate adaptation to ciprofloxacin because the modest increase in the mutation rate associated with SOS mutagenesis is offset by a decrease in the effective strength of selection for increased resistance at a population level. Our findings suggest that the primary evolutionary benefit of the SOS response is to increase bacterial competitive ability, and that stress-induced mutagenesis is an unwanted side effect, and not a selected attribute, of this pathway.
Data from: The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic
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ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD
GEO Series GSE197978. Caulobacter vibrioides. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Listeria monocytogenes SOS response determined after mitomycin C exposure
GEO Series GSE12634. Listeria monocytogenes EGD-e. 16 samples. Type: Expression profiling by array.
Integrated transcriptional regulatory network of quorum sensing, replication, and SOS response in Dinoroseobacter shibae
GEO Series GSE122111. Dinoroseobacter shibae. 27 samples. Type: Expression profiling by high throughput sequencing.
Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction
GEO Series GSE311073. Caulobacter vibrioides. 8 samples. Type: Expression profiling by high throughput sequencing.
Defining the Pseudomonas aeruginosa SOS Response and its Role in the Global Response to the Antibiotic Ciprofloxacin
GEO Series GSE5443. Pseudomonas aeruginosa. 14 samples. Type: Expression profiling by array.
Genome-wide tracking of Escherichia coli DNA polymerase V to the lagging strand during the SOS response
GEO Series GSE158570. Escherichia coli. 51 samples. Type: Other.
An ancestral transmembrane transcription factor couples cell envelope regulation and the SOS response in Caulobacter crescentus
GEO Series GSE310922. Caulobacter vibrioides. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Characterization of the SOS response of Pseudomonas fluorescens strain DC454 using whole genome transcript analysis
GEO Series GSE5653. Pseudomonas fluorescens. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.