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7 results for “STRA6”
STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
<p><span><strong>Background</strong>: </span><span>Metastasis has emerged to be an important cause for poor prognosis of thyroid carcinoma (TC) and its molecular mechanisms are not fully understood. STRA6 is a multifunctional membrane protein widely expressed in embryonic and adult tissues. The function and mechanism of STRA6 in TC remain elusive.</span></p> <p><strong><span>Objective</span></strong><span>: We aimed to explore the role of STRA6 in TC progression and provide a therapeutic target for TC.</span></p> <p><span><strong>Methods</strong>: </span><span>The expression and clinicopathological relevance of STRA6 were explored in TC. Stable STRA6-knockdown TC cells were established and used to determine the biological function of STRA6 <em>in</em> <em>vitro</em> and <em>in</em> <em>vivo</em>. RNA-sequencing and Co-immunoprecipitation were performed to unveil the molecular mechanism of STRA6 in TC progression. The potential of STRA6 as a therapeutic target was evaluated by lipid nanoparticles (LNPs) containing siRNA.</span></p> <p><span><strong>Results</strong>:</span><span> STRA6 was upregulated in TC and correlated with aggressive clinicopathological features including extrathyroidal extension and lymph node metastasis, which contributed to the poor prognosis of TC. STRA6 facilitated TC progression by enhancing proliferation and metastasis <em>in</em> <em>vitro</em> and <em>in</em> <em>vivo</em>. Mechanistically, STRA6 could interact with ILK and subsequently activate the AKT/mTOR signaling pathway. We further unveiled that STRA6 reprogrammed lipid metabolism through SREBP1, which was crucial for the metastasis of TC. Moreover, STRA6 siRNA delivered by LNP significantly inhibited cell growth in xenograft tumor models.</span></p> <p><span><strong>Conclusions</strong>:</span><span> Our study demonstrates the critical roles of STRA6 contributing to TC progression via the ILK/AKT/mTOR axis, which may provide a novel prognostic marker as well as a promising therapeutic target for aggressive TC.</span></p>
STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
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Bulk RNA-seq of eyes isolated from wildtype and Stra6 knockout mice maintained on either a vitamin A sufficient or deficient diet
GEO Series GSE219252. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Gene expression following myocardial infarction in mice with Stimulated by retinoic acid gene 6 (Stra6) germline deletion, Vitamin A deficiency, and the combination of both
GEO Series GSE307187. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
The retinol-binding protein receptor STRA6 contributes to the pathogenesis of adenomyosis via Wnt/β-catenin pathway depression [microRNA]
GEO Series GSE242148. Oryctolagus cuniculus. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The retinol-binding protein receptor STRA6 contributes to the pathogenesis of adenomyosis via Wnt/β-catenin pathway depression [RNA]
GEO Series GSE242145. Oryctolagus cuniculus. 9 samples. Type: Expression profiling by high throughput sequencing.
The retinol-binding protein receptor STRA6 contributes to the pathogenesis of adenomyosis via Wnt/β-catenin pathway depression
GEO Series GSE242149. Oryctolagus cuniculus. 18 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
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