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48 results for “Siglecs”
In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission
<p>Early events in retrovirus transmission are determined by interactions between incoming viruses and frontline cells near entry sites. Despite their importance for retroviral pathogenesis, very little is known about these events. We developed a bioluminescence imaging (BLI)-guided multiscale imaging approach to study these events <i>in vivo</i>. Engineered murine leukemia reporter viruses allowed us to monitor individual stages of retrovirus life cycle including virus particle flow, virus entry into cells, infection and spread for retroorbital, subcutaneous and oral routes. BLI permitted temporal tracking of orally administered retroviruses along the gastrointestinal tract as they traversed the lumen through Peyer's Patches to reach the draining mesenteric sac. Importantly, capture and acquisition of lymph-, blood- and milk-borne retroviruses spanning three routes, was promoted by a common host factor, the I-type lectin CD169, expressed on sentinel macrophages. These results highlight how retroviruses co-opt the immune surveillance function of tissue resident sentinel macrophages for establishing infection.</p>
In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission
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PET Imaging of Cancer Patients Using 68Ga-DOTA-Siglec-9
ClinicalTrials.gov study NCT05212103. IPD Sharing: NO. Countries: 1. Publications: 1.
Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis, Vasculitis or Pulmonary Sarcoidosis
ClinicalTrials.gov study NCT03755245. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Evolution of the exclusively human-pathogen Neisseria gonorrhoeae: human-specific engagement of immunoregulatory Siglecs
Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhea exclusively in humans and uses multiple strategies to infect, including acquisition of host sialic acids that cap and mask lipooligosaccharide termini, while restricting complement activation. We hypothesized that gonococci selectively target human anti-inflammatory sialic acid-recognizing Siglec receptors on innate immune cells to blunt host responses, and that pro-inflammatory Siglecs and SIGLEC pseudogene polymorphisms represent host evolutionary adaptions to counteract this interaction. N. gonorrhoeae can indeed engage multiple human but not chimpanzee CD33rSiglecs expressed on innate immune cells and in the genitourinary tract––including Siglec-11 (inhibitory) and Siglec-16 (activating), which we detected for the first time on human cervical epithelium. Surprisingly, in addition to LOS-sialic acid, we found that gonococcal porin (PorB) mediated binding to multiple Siglecs. PorB also bound preferentially to human Siglecs and not chimpanzee orthologs, modulating host immune reactions in a human-specific manner. Lastly, we studied the distribution of null SIGLEC polymorphisms in a Namibian cohort with a high prevalence of gonorrhea, and found that uninfected women preferentially harbor functional SIGLEC16 alleles encoding an activating immune receptor. These results contribute to the understanding of the human specificity of N. gonorrhoeae and how it evolved to evade the human immune defense.
Data from: Evolution of the exclusively human-pathogen Neisseria gonorrhoeae: human-specific engagement of immunoregulatory Siglecs
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The Receptor Binding Domain of SARS-CoV-2 Omicron Subvariants Targets Siglec-9 to Decrease the Immunogenicity by Preventing Phagocytosis of Macrophages
GEO Series GSE251973. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Human primary macrophages derived in vitro from circulating monocytes comprise adherent and non-adherent subsets with differential expression of Siglec-1 and CD4 and permissiveness to HIV-1 infection
GEO Series GSE103666. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A genetic screen in fetal liver-derived alveolar-like macrophages (FLAMs) identifies new regulators of Siglec-F surface expression
GEO Series GSE195868. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The lectin Siglec-G functions as an inhibitory receptor in CD8+ T cell and can be targeted to enhance therapeutic antitumor immunity.
GEO Series GSE255336. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
γδ+ T cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F+ neutrophil development in PPE-induced emphysema
GEO Series GSE297403. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Plasmacytoid dendritic cell precursors give rise to conventional dendritic cells via a Siglec-H+ Zbtb46+ Ly6D+ intermediary stage
GEO Series GSE189780. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tumor-derived kynurenine induces Siglec-15 expression and promotes CD8+T cell exhaustion in oral squamous cell carcinoma
GEO Series GSE222673. Homo sapiens. 138 samples. Type: Expression profiling by high throughput sequencing.
Human-Specific Elimination of Epithelial Siglec-XII Suppresses the Risk of CRC Initiation and Progression [baseline]
GEO Series GSE262086. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Siglec-E is a Critical Inhibitory Receptor Controlling APC Activation and T Cell-Mediated Transplant Rejection
GEO Series GSE271770. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The Siglec-sialic acid-axis is a target for innate immunotherapy of glioblastoma
GEO Series GSE212616. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Siglec-9 acts as an immune checkpoint molecule on macrophages in glioblastoma, restricting T cell priming and immunotherapy response [scRNA-seq]
GEO Series GSE235676. Homo sapiens; Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
Effect of deficiency of Siglec-15 during osteoclast differentiation of murine bone marrow macrophages
GEO Series GSE218768. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Siglec-9 acts as an immune checkpoint molecule on macrophages in glioblastoma, restricting T cell priming and immunotherapy response [ST]
GEO Series GSE235672. Homo sapiens. 20 samples. Type: Other.
Tuberculosis-associated IFN-I induces Siglec-1 on microtubule-containing tunneling nanotubes and favors HIV-1 spread in macrophages
GEO Series GSE139511. Homo sapiens. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.