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ShareScore release 0.9.0
Dataset results
14 results for “Single neuron function”
Functional interactions among neurons within single columns of macaque V1
<p>Recent developments in high-density neurophysiological tools now make it possible to record from hundreds of single neurons within local, highly interconnected neural networks. Among the many advantages of such recordings is that they dramatically increase the quantity of identifiable, functional interactions between neurons thereby providing an unprecedented view of local circuits. Using high-density, Neuropixels recordings from single neocortical columns of primary visual cortex in nonhuman primates, we identified 1000s of functionally interacting neuronal pairs using established crosscorrelation approaches. Our results reveal clear and systematic variations in the synchrony and strength of functional interactions within single cortical columns. Despite neurons residing within the same column, both measures of interactions depended heavily on the vertical distance separating neuronal pairs, as well as on the similarity of stimulus tuning. In addition, we leveraged the statistical power afforded by the large numbers of functionally interacting pairs to categorize interactions between neurons based on their crosscorrelation functions. These analyses identified distinct, putative classes of functional interactions within the full population. These classes of functional interactions were corroborated by their unique distributions across defined laminar compartments and were consistent with known properties of V1 cortical circuitry, such as the lead-lag relationship between simple and complex cells. Our results provide a clear proof-of-principle for the use of high-density neurophysiological recordings to assess circuit-level interactions within local neuronal networks.</p>
Functional interactions among neurons within single columns of macaque V1
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Single-cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures
GEO Series GSE192405. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Single-cell functional transcriptomics of mouse DRG mechanosensory neurons
GEO Series GSE168032. Mus musculus. 53 samples. Type: Expression profiling by high throughput sequencing.
Functional characterization of a single nucleotide polymorphism associated with Alzheimer’s Disease in a hiPSC-based neuron model.
GEO Series GSE239367. Homo sapiens. 100 samples. Type: Expression profiling by high throughput sequencing.
Somatosensory Neuron Types Identified by High-Coverage Single-Cell RNA-Sequencing and Functional Heterogeneity
GEO Series GSE63576. Mus musculus. 209 samples. Type: Expression profiling by high throughput sequencing.
Correlating anatomy and function with gene expression in individual neurons by combining in vivo labeling, patch clamp and single cell RNA-seq
GEO Series GSE90822. Mus musculus. 927 samples. Type: Expression profiling by high throughput sequencing.
Single-cell profiling and functional characterization bridge molecular and functional features of NAc neuron subtype
GEO Series GSE118020. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Striatal cultured neurons single-nucleus RNA-seq dataset for "A dopamine-induced coordinated gene expression program regulates neuronal function and cocaine response"
GEO Series GSE137759. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology
GEO Series GSE159074. Homo sapiens. 56 samples. Type: Expression profiling by high throughput sequencing.
Functional In vivo Recording and Single-cell Transcriptome Analysis Reveals Molecular Properties of Light-Sensitive Neurons in Mouse V1
GEO Series GSE115997. Mus musculus. 63 samples. Type: Expression profiling by high throughput sequencing.
Adult nucleus accumbens single-nucleus RNA-seq dataset for "A dopamine-induced coordinated gene expression program regulates neuronal function and cocaine response"
GEO Series GSE137763. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
A Study of the Higher Cognitive Functions of the Human Brain With Single-neuron Activity Recording
ClinicalTrials.gov study NCT06408415. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Multiplex single cell analysis of serotonergic neuron function in planarians reveals widespread effects in diverse cell types
GEO Series GSE256032. Schmidtea mediterranea. 5 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.