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35
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ShareScore release 0.9.0
Dataset results
35 results for “Single-Cell Pathology”
Molecular and spatial signatures of human and rat corpus cavernosum physio-pathological processes at single-cell resolution
<p><span>The composition and cellular heterogeneity of the corpus cavernosum (CC) microenvironment has been characterized, but the spatial heterogeneity at the molecular level remains unexplored. In this study, we integrate single-cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing to comprehensively chart the spatial cellular landscape of human and rat CC under normal and disease conditions. We observe differences in the proportion of cell subtypes and marker genes between humans and rats. Based on the analysis of the fibroblasts (FB) niche, we also find that the enrichment scores of mechanical force signaling vary across different regions and correlate with the spatial distribution of FB subtypes. In vitro, the soft and hard extracellular matrix (ECM) induces the differentiation of FB into APO+FB and COMP+FB, respectively. In summary, our study provides a cross-species and </span><span>physio-pathological</span><span> </span><span>transcriptomic atlas of the CC, contributing to a further understanding of the molecular anatomy and regulation of penile erection.</span></p>
Cellular and molecular heterogeneities and signatures, and pathological trajectories of fatal COVID-19 lungs defined by spatial single-cell transcriptome analysis
<p>Spatial in-situ data analysis.</p>
Single-cell RNA-seq uncovers the pathological alterations of pancreatic islets in type 2 diabetes mice
GEO Series GSE200531. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infection
GEO Series GSE283518. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia
GEO Series GSE268807. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [Multiome snRNA/snATAC]
GEO Series GSE236903. Gallus gallus. 4 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Single-cell atlas of human infrapatellar fat pad and synovium unravels mechanisms of osteoarthritis-induced joint pathology
GEO Series GSE216651. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases [scRNA-Seq]
GEO Series GSE185696. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during murine atherosclerosis
GEO Series GSE239591. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2 [gene expression levels]
GEO Series GSE164013. Homo sapiens. 80 samples. Type: Expression profiling by high throughput sequencing.
Single-cell Transcriptome Analyses Reveal Unique Microglia Types Associated with Retinal Pathological Angiogenesis
GEO Series GSE199792. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Single-cell analysis of pathology in Klinefelter syndrome and idiopathic male infertility
GEO Series GSE169062. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Deciphering the role of oligodendroglial Serpina3n in EAE pathology using single-cell RNA sequencing
GEO Series GSE287310. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases [RNA-Seq]
GEO Series GSE185710. Mus musculus. 41 samples. Type: Expression profiling by high throughput sequencing.
Distinguishing Keratoacanthoma from Well-Differentiated Cutaneous Squamous Cell Carcinoma Using Single-cell Spatial Pathology
GEO Series GSE235556. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomic analysis reveals alterations to cellular dynamics and paracrine signalling in radiation-induced muscle pathology
GEO Series GSE241675. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during murine atherosclerosis
GEO Series GSE239602. Mus musculus. 82 samples. Type: Expression profiling by high throughput sequencing.
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases
GEO Series GSE185711. Mus musculus. 47 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomic atlas reveals tissue architecture and deciphers pathological reprogramming during retinal ischemia in Macaca fascicularis
GEO Series GSE242229. Macaca fascicularis. 2 samples. Type: Expression profiling by high throughput sequencing.
Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology
GEO Series GSE150672. Homo sapiens; Mus musculus. 438 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.