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12 results for “Soil-transmitted helminth”
Eco-evolutionary dynamics of anthelmintic resistance in soil-transmitted helminths
<p>Anthelmintic resistance (AR) of helminth parasites against the most widely available drugs is an ongoing concern for both human and livestock-infecting species. Indeed, there has been substantial evidence of AR in livestock but less in humans, which may be due to a variety of reasons. In this paper, we develop an eco-evolutionary model that couples the life cycle of these parasites with their underlying evolution in a single biallelic genetic locus that confers resistance to treatment drugs. We determine the critical treatment frequency needed to effectively eliminate the population, for a fixed drug efficacy (without evolution) and use this to classify three qualitative distinct behaviors of the eco-evolutionary model. Then, we describe how aspects of the life cycle influence which qualitative outcome is achieved and the spread of the resistance allele, comparing across human- and livestock- infecting species. For all but one species, we find that lower fecundity rates and lower contact rates speed the spread of resistance, while lower larval death slows it down. The life cycle parameters of <em>Ancylostoma duodenale</em> and <em>Ostertagia circumcincta</em> are associated with the fastest and slowest spread of resistance, respectively. We discuss the mechanistic reason for these results.</p>
Eco-evolutionary dynamics of anthelmintic resistance in soil-transmitted helminths
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Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
ClinicalTrials.gov study NCT03014167. IPD Sharing: Not stated. Countries: 3. Publications: 19.
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
ClinicalTrials.gov study NCT06736691. IPD Sharing: YES. Countries: 1. Publications: 2.
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
ClinicalTrials.gov study NCT06800248. IPD Sharing: YES. Countries: 1. Publications: 2.
Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya
ClinicalTrials.gov study NCT02397772. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia
ClinicalTrials.gov study NCT00349323. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections
ClinicalTrials.gov study NCT01350271. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The immune response and microbiota profiles during co-infection with P. vivax and soil-transmitted helminths
GEO Series GSE144792. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs
ClinicalTrials.gov study NCT04177654. IPD Sharing: YES. Countries: 8. Publications: 0.
Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene Education
ClinicalTrials.gov study NCT04227834. IPD Sharing: NO. Countries: 1. Publications: 0.
Burden of Schistosomiasis and Soil-transmitted Helminth Infections in Schoolchildren in Banfora, Burkina Faso
ClinicalTrials.gov study NCT06973200. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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