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147 results for “Somatostatin”
Dataset for the manuscript "ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the central canal"
<p>Description: Dataset that supports the expansion-STED and light sheet microscopy methods in spinal cord and support the findings in the manuscript: ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the central canal (Elham Jalalvand, Jonatan Alvelid, Giovanna Coceano, Steven Edwards, Brita Robertson, Sten Grillner, Ilaria Testa).</p> <p>The software used to open the files and perform the analysis: Imspector v0.10_rev8575 and ImageJ 1.52i.</p> <p>The preprint of the manuscript can be found here: https://doi.org/10.1101/2021.08.17.456595</p>
Pasireotide in Patients With Acromegaly Inadequately Controlled With First Generation Somatostatin Analogues
ClinicalTrials.gov study NCT02354508. IPD Sharing: YES. Countries: 15. Publications: 1.
A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours
ClinicalTrials.gov study NCT01578239. IPD Sharing: YES. Countries: 8. Publications: 4.
Long-lasting, subtype-specific regulation of somatostatin interneurons during sensory learning
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Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories
<p>Spatial transcriptomic data with 94 gene panels on P5 mouse neocortex. Files here include raw tiff files, results/spot counts, DAPI files for ROI segmentation, ROI segmented, final measurement with annotated region and counts. </p>
Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development
<p>During brain development, neural circuits undergo major activity-dependent restructuring. Circuit wiring mainly occurs through synaptic strengthening following the Hebbian “fire together, wire together” precept. However, select connections, essential for circuit development, are transient. They are effectively connected early in development, but strongly diminish during maturation. The mechanisms by which transient connectivity recedes are unknown. To investigate this process, we characterize transient thalamocortical inputs, which depress onto somatostatin inhibitory interneurons during development, by employing optogenetics, chemogenetics, transcriptomics and CRISPR-based strategies. We demonstrate that in contrast to typical activity-dependent mechanisms, transient thalamocortical connectivity onto somatostatin interneurons is non-canonical and involves metabotropic signaling. Specifically, metabotropic-mediated transcription, of guidance molecules in particular, supports the elimination of this connectivity. Remarkably, we found that this developmental process impacts the development of normal exploratory behaviors of adult mice.</p>
Data and code for: Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior
<p>Our dataset reflects the data and code used in Brockway et al., Cell Reports. We sought to characterize the unique role of somatostatin (SST) in the prelimbic (PL) cortex. We perform slice electrophysiology in pyramidal and GABAergic neurons to characterize the pharmacological mechanism of SST signaling, and fiber photometry of GCaMP6f fluorescent calcium signals from SST neurons to characterize the activity profile of SST neurons during exploration of an elevated plus maze (EPM) and open field test (OFT). We used local delivery of a broad SST receptor (SSTR) agonist and antagonist to test causal effects of SST signaling. SSTR activation hyperpolarizes layer 2/3 pyramidal neurons, an effect that is recapitulated with optogenetic stimulation of SST neurons. SST neurons in PL are activated during EPM and OFT exploration, and SSTR agonist administration directly into the PL enhances open-arm exploration in the EPM. This work describes a broad ability for SST peptide signaling to modulate microcircuits within the prefrontal cortex and related exploratory behaviors.</p>
Comparison of Oral Octreotide Capsules to Injectable Somatostatin Analogs in Acromegaly
ClinicalTrials.gov study NCT02685709. IPD Sharing: NO. Countries: 13. Publications: 3.
A Phase II Study of Ramucirumab With Somatostatin Analog Therapy in Patients With Advanced, Progressive Carcinoid Tumors
ClinicalTrials.gov study NCT02795858. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Application Study of [123I]Metaiodobenzylguanidine and Somatostatin Receptor-Targeted Imaging in the Diagnosis and Staging of Neuroblastoma
ClinicalTrials.gov study NCT07064746. IPD Sharing: YES. Countries: 1. Publications: 28.
Imaging of Patients With Known or Suspected Somatostatin Receptor Positive Neuroendocrine Tumors Using Cu64-DOTATATE
ClinicalTrials.gov study NCT03673943. IPD Sharing: NO. Countries: 1. Publications: 1.
Somatostatin Analogue SOM230 (Pasireotide) in Healthy Male Volunteers
ClinicalTrials.gov study NCT01128192. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome)
ClinicalTrials.gov study NCT01677910. IPD Sharing: Not stated. Countries: 12. Publications: 6.
Clinical Application of Somatostatin Receptor and Norepinephrine Transporter Targeted Imaging for Diagnosis and Staging of Neuroblastoma and Pheochromocytoma/Paraganglioma
ClinicalTrials.gov study NCT07195500. IPD Sharing: YES. Countries: 1. Publications: 10.
Central amygdala somatostatin neurons modulate stress-induced sleep-onset insomnia
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Data from: Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network
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Data and code for: Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior
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The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development
<p><span>Glucose homeostasis is maintained by hormones secreted from different cell types of the pancreatic islets and controlled by manifold input including signals mediated through G protein-coupled receptors (GPCRs). RNA-seq analyses revealed expression of numerous GPCRs in mouse and human pancreatic islets, among them <em>Gpr116</em>/<em>Adgrf5</em>. GPR116 is an adhesion GPCR mainly found in lung and required for surfactant secretion. Here, we demonstrate that GPR116 is involved in the somatostatin release from pancreatic delta cells using a whole-body as well as a cell-specific knock-out mouse model. Interestingly, the whole-body GPR116 deficiency causes further changes such as decreased beta-cell mass, lower number of small islets, and reduced pancreatic insulin content. Glucose homeostasis in global GPR116-deficient mice is maintained by counter-acting mechanisms modulating insulin degradation. Our data highlight an important function of GPR116 in controlling glucose homeostasis. </span></p>
Somatostatin Analogues as a Volume Reducing Treatment of Polycystic Livers (RESOLVE)
ClinicalTrials.gov study NCT01354405. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Recurrence Rates of Type I Gastric Neuroendocrine Tumors Treated With Long-acting Somatostatin Analogs
ClinicalTrials.gov study NCT03812939. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.