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141 results for “Specific risk”
BIDS wildtype data selection from "Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories"
<p>Data package selecting wildtype animals from the “Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories” article, formatted corresponding to the Brain Imaging Data Structure. The relevant publication can be found via DOI <a href="https://doi.org/10.1093/cercor/bhy046">10.1093/cercor/bhy046</a> .</p>
Figure 5 in A simplistic water body-specific risk assessment model for zebra mussel (Dreissena polymorpha) establishment based on physicochemical characteristics
Figure 5. Overall zebra mussel establishment risk categorization of 133 Texas water bodies based on calcium, pH, salinity, and temperature. Major water bodies not included in this study due to lack of TCEQ water quality data are shown for context of the study extent. The Whittier et. al. low calcium/low risk zone delineation is shown to demonstrate level of agreement with that study, which is relatively high with some noteworthy exceptions. The Cypress, Sabine, and Neches River basins referenced in the text are the three East Texas basins with predominantly minimal risk water body categorizations.
Figure 2 in A simplistic water body-specific risk assessment model for zebra mussel (Dreissena polymorpha) establishment based on physicochemical characteristics
Figure 2. pH-based zebra mussel establishment risk categorization of 133 Texas water bodies. Major water bodies not included in this study due to lack of TCEQ water quality data are shown for context of the study extent.
Figure 4 in A simplistic water body-specific risk assessment model for zebra mussel (Dreissena polymorpha) establishment based on physicochemical characteristics
Figure 4. Temperature-based zebra mussel establishment risk categorization of 126 Texas water bodies. Major water bodies not included in this study due to lack of TCEQ water quality data are shown for context of the study extent.
Figure 3 in A simplistic water body-specific risk assessment model for zebra mussel (Dreissena polymorpha) establishment based on physicochemical characteristics
Figure 3. Salinity-based zebra mussel establishment risk categorization of 133 Texas water bodies. Major water bodies not included in this study due to lack of TCEQ water quality data are shown for context of the study extent.
Figure 1 in A simplistic water body-specific risk assessment model for zebra mussel (Dreissena polymorpha) establishment based on physicochemical characteristics
Figure 1. Calcium-based zebra mussel establishment risk categorization of 85 Texas water bodies. Areas to the east of the Whittier et al. (2008) calcium risk delineation were predicted by that study to have ≤ 12 mg/l calcium (i.e., minimal establishment risk); this delineation is shown to demonstrate level of agreement with that study. Major water bodies not included in this study due to lack of TCEQ water quality data are shown for context of the study extent. The Cypress, Sabine, and Neches River basins referenced in the text are the three East Texas basins with predominantly minimal risk water body categorizations.
Form-specific prospective environmental risk assessment of graphene-based materials in European Freshwaters
<p>This dataset is related to the following publication:</p> <p>Title: Form-specific prospective environmental risk assessment fo graphene-based materials in European freshwaters</p> <p>Authors: Hyunjoo Hong, Bernd Nowack </p> <p>The files contain input files and final codes of the fs-MFA and fs-PSSD models.</p>
Data for: Developmental origins of Parkinson’s disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain
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A specific IL6 polymorphic genotype modulates the risk of T. cruzi parasitemia while IL18, IL17A and IL1B variant profiles and HIV infection protect against cardiomyopathy in Chagas disease
<p><strong>Background:</strong> Chagas disease caused by Trypanosoma cruzi (T. cruzi) affects approximately six million individuals worldwide. Clinical manifestations are expected to occur due to the parasite persistence and host immune response. Herein we investigated potential associations between IL1B, IL6, IL17A or IL18 polymorphism profiles and cardiomyopathy or T. cruzi parasitemia, as well as the impact of HIV infection on cardiopathy.</p> <p><strong>Methods:</strong> 206 patients and 90 control individuals were analyzed. IL1B rs1143627 T>C, IL6 rs1800795 C>G, IL17A rs2275913 G>A, IL18 rs187238 C>G, and IL18 rs1946518 C>A SNVs were analyzed by real-time PCR and T. cruzi parasitemia by PCR.</p> <p><strong>Results: </strong>Our data revealed association between a cytokine gene polymorphism and parasitemia never previously reported. The IL6 rs1800795 CG genotype lowered the risk of positive parasitemia (OR=0.45, 95% CI 0.24–0.86, P=0.015). Original findings included associations between IL17A rs2275913 AA and IL18 s1946518 AA genotypes with decreased risk of developing cardiomyopathy (OR=0.27, 95% CI 0.07-0.97, P=0.044; and OR=0.35, 95% CI 0.14-0.87, P=0.023, respectively). IL18 rs1946518 AA and IL1B rs1143627 TC were associated with reduced risk for cardiomyopathy severity, including NYHA (New York Heart Association) class≥ 2 (OR=0.21, 95% CI 0.06-0.68, P=0.009; and OR=0.48, 95% CI 0.24-0.95, P=0.036, respectively) and LVEF (Left Ventricular Ejection Fraction) <45% for IL18 rs1946518 AA (OR=0.22, 95% CI 0.05-0.89, P=0.034). A novel, unexpected protective effect of HIV infection against development/progression of cardiomyopathy was identified, based on a lower risk of developing cardiopathy (OR=0.48, 95% CI 0.23‐0.96, P=0.039), NYHA class≥2 (OR=0.15, 95% CI 0.06‐0.39, P<0.001) and LVEF<45% (OR=0.03, 95% CI 0.00‐0.25, P=0.001). Digestive involvement was negatively associated with NYHA ≥2 and LVEF<45% (OR=0.20, 95% CI 0.09‐0.47, P<0.001; and OR=0.24, 95% CI 0.09-0.62, P=0.004, respectively).</p> <p><strong>Conclusions: </strong>Our data support a protective role of IL17A AA, IL18 AA and IL1B TC genotypes against development/progression of cardiomyopathy and a modulatory effect of the IL6 CG genotype on the risk of parasitemia in Chagas disease. Notably, HIV infection was shown to protect against development/progression of cardiopathy, potentially associated with a synergistic effect of HIV and HAART, attenuating a Th1-mediated response in the myocardium. This proposed hypothesis requires confirmation, however, in larger and more comprehensive future studies.</p>
Pathogen group-specific risk factors for intra-mammary infection in water buffalo
<p>A cross-sectional study was conducted to estimate the prevalence of intra-mammary infection (IMI) associated bacteria and to identify risk factors for pathogen group-specific IMI in water buffalo in Bangladesh. A California Mastitis Test (CMT) and bacteriological cultures were performed on 1,374 quarter milk samples collected from 763 water buffalo from 244 buffalo farms in nine districts in Bangladesh. Quarter, buffalo, and farm-related data were obtained through questionnaires and visual observations. A total of 618 quarter samples were found to be culture-positive. Non-<em>aureus</em> staphylococci were the predominant IMI-associated bacterial species, and <em>Staphylococcus </em>(<em>S.</em>)<em> chromogenes</em>, <em>S. hyicus</em>, and <em>S. epidermidis </em>were the most common bacteria found. The proportion of non-aureus staphylococci or <em>Mammaliicoccus sciuri</em> (NASM), <em>S. aureus</em>, and other bacterial species identified in the buffalo quarter samples varied between buffalo farms. Therefore, different management practices, buffalo breeding factors, and nutrition were considered and further analyzed when estimating the IMI odds ratio (OR). The odds of IMI by any pathogen (OR: 1.8) or by NASM (OR: 2.2) were high in buffalo herds with poor milking hygiene. Poor cleanliness of the hind quarters had a high odds of IMI caused by any pathogen (OR: 2.0) or NASM (OR: 1.9). Twice daily milking (OR: 3.1) and farms with buffalo purchased from another herd (OR: 2.0) were associated with IMI by any pathogen. Asymmetrical udders were associated with IMI-caused by any bacteria (OR: 1.7). A poor body condition score showed higher odds of IMI by any pathogen (OR: 1.4) or by NASM (OR: 1.7). This study shows that the prevalence of IMI in water buffalo was high and varied between farms. In accordance with the literature, our data highlight that IMI can be partly controlled through better farm management, primarily by improving hygiene, milking management, breeding, and nutrition.</p>
Risk Factors of Non-specific Low Back Pain in a Rural Community of Bangladesh
<p><strong>Risk Factors of Non-specific Low Back Pain in a Rural Community of Bangladesh</strong></p>
HLA epitopic mismatch and risk of developing Donor Specific Antibodies in pediatric kidney transplantation
<p>The aim of this study was to evaluate the correlation between epitopic HLA mismatches and the risk of developing DSA in pediatric kidney recipients. There are very few publications concerning epitope HLA mismatch in pediatric kidney transplantation although this topic has been growing in scientific articles in recent years and is promising in adult recipients. The majority of children with chronic renal failure will require multiple kidney transplants during their lifetime and it is therefore important that we can limit the risk of antibody development in order to give them the best chance of survival for their future kidney transplants.</p>
Regional and global climate risks for reef corals: incorporating species-specific vulnerability and exposure to climate hazards
<p>Climate change is driving rapid and widespread erosion of the environmental conditions that formerly supported species persistence. Existing projections of climate change typically focus on forecasts of acute environmental anomalies and global extinction risks. The current projections also frequently consider all species within a broad taxonomic group together without differentiating species-specific patterns. Consequently, we still know little about the explicit dimensions of climate risk (i.e., species-specific vulnerability, exposure and hazard) that are vital for predicting future biodiversity responses (e.g., adaptation, migration) and developing management and conservation strategies. Here, we use reef corals as model organisms (n = 741 species) to project the extent of regional and global climate risks of marine organisms into the future. We characterise species-specific vulnerability based on the global geographic range and historical environmental conditions (1900–1994) of each coral species within their ranges and quantify the projected exposure to climate hazard beyond the historical conditions as climate risk. We show that many coral species will experience a complete loss of pre-modern climate analogs at the regional scale and across their entire distributional ranges, and such exposure to hazardous conditions is predicted to pose substantial regional and global climate risks to reef corals. Although high-latitude regions may provide climate refugia for some tropical corals until the mid-21st century, they will not become a universal haven for all corals. Notably, high-latitude specialists and species with small geographic ranges remain particularly vulnerable as they tend to possess limited capacities to avoid climate risks (e.g., via adaptive and migratory responses). Predicted climate risks are amplified substantially under the SSP5-8.5 compared with the SSP1-2.6 scenario, highlighting the need for stringent emission controls. Our projections of both regional and global climate risks offer unique opportunities to facilitate climate action at spatial scales relevant to conservation and management.</p>
Location specific risk factors for intracerebral hemorrhage: Systematic review and meta-analysis
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Sex-specific foraging of an apex predator puts females at risk of human-wildlife conflict
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Pathogen group-specific risk factors for intra-mammary infection in water buffalo
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Regional and global climate risks for reef corals: incorporating species-specific vulnerability and exposure to climate hazards
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A specific IL6 polymorphic genotype modulates the risk of T. cruzi parasitemia while IL18, IL17A and IL1B variant profiles and HIV infection protect against cardiomyopathy in Chagas disease
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Data from: Colonization across gradients of risk and reward: nutrients and predators generate species-specific responses among aquatic insects
1. Predation risk and resource abundance are two primary characteristics that determine species abundances and community composition. Colonizing organisms should attempt to minimize the risk of mortality and maximize growth through selection of patches with the highest expected fitness. However, maximizing fitness across multiple gradients of patch quality involves accurate cue assessment, integration, and behavioral responses that consider multiple factors that affect fitness simultaneously. 2. Our goal was to simultaneously and factorially assess the effects of predation risk and resource abundance among an assemblage of aquatic insects to determine the relative importance of each factor, and whether the two factors interact to affect colonization, oviposition, and community assembly. 3. We conducted a field mesocosm experiment in which we crossed predator density (0, 1, 2 fish, Fundulus chrysotus) with supplemental nutrient abundance (0, 4, 8 g rabbit chow) in a 3 × 3 factorial design. We then assayed colonization by natural populations of aquatic beetles and oviposition by Culex mosquitoes. 4. We observed species-specific responses, with many species avoiding fish and some selecting habitats with more nutrients. Nutrients and predator presence only interactively affected oviposition by Culex mosquitoes, and the effect of fish presence exceeded that of nutrients in all but one analysis. 5. Our results illustrate the primacy of predation risk in generating colonization patterns and structuring communities in aquatic habitats, but that colonization responses to variation in multiple components of patch quality are often species-specific. Simultaneous assessments of multiple aspects of patch quality allow for the determination of potential interactions among cue sources and the relative importance of various patch characteristics to colonizers.
Data from: Risks of 23 specific malformations associated with prenatal exposure to ten antiepileptic drugs
Objective: To assess the association between exposure to monotherapy with 10 different antiepileptic drugs (AED) during the first two months of pregnancy and the risk of 23 major congenital malformations (MCMs). Methods: This nationwide cohort study, based on the French healthcare databases, included all pregnancies&[ge]20 weeks and ending between January 2011 and March 2015. Women were considered to be exposed when an AED had been dispensed between one month before and two months after the beginning of pregnancy. The reference group included pregnant women with no reimbursement for AEDs. MCMs were detected up to 12 months after birth (24 months for microcephaly, hypospadias and epispadias). Odds ratios were adjusted for potential confounders for MCMs with at least five cases. Otherwise, we calculated crude ORs with exact confidence intervals. Results: The cohort included 1,886,825 pregnancies, 2,997 of which were exposed to lamotrigine, 1,671 to pregabalin, 980 to clonazepam, 913 to valproic acid, 579 to levetiracetam, 517 to topiramate, 512 to carbamazepine, 365 to gabapentin, 139 to oxcarbazepine and 80 to phenobarbital. Exposure to valproic acid was associated with 8 specific types of MCMs (e.g. spina bifida, OR=19.4[8.6-43.5]) and exposure to topiramate was associated with an increased risk of cleft lip (6.8[1.4-20.0]). We identified three other signals. We found no significant association for lamotrigine, levetiracetam, carbamazepine, oxcarbazepine and gabapentin. Conclusions: These results confirm the teratogenicity of valproic acid and topiramate. Because of the small numbers of cases and possible confounding, the other three signals should be interpreted with appropriate caution.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.