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21 results for “Sphingosine 1-phosphate”
Dataset for the Sphingosine 1-phosphate receptor 1 (S1PR1) antibody screening study
<p><strong><span>This antibody characterization dataset is related to the F1000 research article openly available at F1000Research.</span></strong></p> <p><em>This project contains the following underlying data included in a study aimed at characterizing nine commercial antibodies against Sphingosine 1-phosphate receptor 1 (S1PR1) protein, encoded by S1PR1 gene. The study is available on Zenodo (<a href="https://doi.org/10.5281/zenodo.10819189">https://doi.org/10.5281/zenodo.10819189</a>).</em></p> <p><em>The Dataset is in the format of a zip file. Once downloaded, please expand the zip file to access the folders containing the underlying data for Western blot (Wb), immunoprecipitation (IP) and immunofluorescence (IF).</em></p>
Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal neovascularization
<p>Sphingosine-1-phosphate (S1P), the circulating HDL-bound lipid mediator that acts via S1P receptors (S1PR), is required for normal vascular development. The role of this signaling axis in vascular retinopathies is unclear. Here we show in a mouse model of oxygen-induced retinopathy (OIR) that endothelial overexpression of <em>S1pr1</em> suppresses while endothelial knockout of <em>S1pr1</em> worsens neovascular tuft formation. Furthermore, neovascular tufts are increased in <em>Apom<sup>-/-</sup> </em>mice which lack HDL-bound S1P while they are suppressed in <em>Apom<sup>TG</sup> </em>mice which has more circulating HDL-S1P. These results suggest that circulating HDL-S1P activation of endothelial S1PR1 suppresses neovascular pathology in OIR. Additionally, systemic administration of ApoM-Fc-bound S1P or a small molecule Gi-biased S1PR1 agonist suppressed neovascular tuft formation. Circulating HDL-S1P activation of endothelial S1PR1 may be a key protective mechanism to guard against neovascular retinopathies that occur not only in premature infants but also in diabetes and aging.</p>
Role of supraspinal sphingosine-1-phosphate receptor 1 in neuropathic pain
<p><span>An unbiased transcriptomic analysis of the RVM was used to identify genes affected by nerve injury and the impact of S1PR1 antagonism. </span></p>
A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers.
ClinicalTrials.gov study NCT01466322. IPD Sharing: YES. Countries: 1. Publications: 4.
Data from: Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication
Open the record for dataset details and reuse information.
Sphingosine 1-phosphate receptor signaling establishes AP-1 transcriptional factor gradients and permits retinal endothelial specialization
GEO Series GSE141440. Mus musculus. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Sphingosine 1-phosphate maintains naïve T cell by regulating apoptotic signaling
GEO Series GSE221482. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
GEO Series GSE139065. Mus musculus. 25 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Blood-borne sphingosine 1-phosphate maintains vascular resistance and cardiac function.
GEO Series GSE289865. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Role of Urinary Sphingosine 1-Phosphate as a Biomarker for Detrusor Hyperactivity in Multiple Sclerosis
ClinicalTrials.gov study NCT06161376. IPD Sharing: NO. Countries: 1. Publications: 0.
Proximod, a Selective Sphingosine-1-phosphate Receptor 1 Modulator in Patients With Moderate-to-severe Active Rheumatoid Arthritis: a Double-blind, Randomised, Placebo-controlled, Phase 2 Trial.
ClinicalTrials.gov study NCT07335952. IPD Sharing: YES. Countries: 1. Publications: 0.
Ichthyosis associated with sphingosine 1-phosphate lyase insufficiency syndrome is due to aberrant calcium and sphingolipid regulation
GEO Series GSE207499. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Sphingosine 1-phosphate effect on glioblastoma cells in vitro
GEO Series GSE4817. Homo sapiens. 6 samples. Type: Expression profiling by array.
A Sphingosine 1-Phosphate 1 Receptor Agonist Modulates Brain Death-Induced Neurogenic Pulmonary Injury
GEO Series GSE22531. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
GEO Series GSE60761. Mus musculus. 12 samples. Type: Expression profiling by array.
Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis
GEO Series GSE40368. Mus musculus. 10 samples. Type: Expression profiling by array.
The Role of Sphingosine 1 Phosphate Receptor 2 Signaling in Chronic Glucocorticoid Exposure Induced Hepatic Steatosis and Hypertriglyceridemia
GEO Series GSE286363. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis and Embryogenesis
<p>Lipidomics and Proteomics data sets referred in preprint: 10.1101/2021.08.12.456080</p> <p> </p>
Effects of Sphingosine 1-Phosphate on Gene Expression in C3H10T1/2 Cells via RNA-seq
GEO Series GSE108681. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Sphingosine-1 phosphate receptor 1 (S1PR1) is crucial for maintaining the stem cell properties of acute myeloid leukemia stem cells
GEO Series GSE230423. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.