Find research datasets worth reusing

Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 2

ClinicalTrials.gov study NCT02660359. IPD Sharing: YES. Countries: 16. Publications: 1.

Multimodal Exercises to Improve Leg Function After Spinal Cord Injury

ClinicalTrials.gov study NCT01740128. IPD Sharing: YES. Countries: 1. Publications: 2.

Neurogenic Detrusor Overactivity Following Spinal Cord Injury or Multiple Sclerosis

ClinicalTrials.gov study NCT01357980. IPD Sharing: YES. Countries: 5. Publications: 1.

Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury

ClinicalTrials.gov study NCT03854214. IPD Sharing: YES. Countries: 1. Publications: 4.

Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1

ClinicalTrials.gov study NCT02660138. IPD Sharing: YES. Countries: 10. Publications: 1.

opencc-by-4.0Feb 2024View details →

Datasets related to the manuscript 'Hypothalamic deep brain stimulation augments walking after spinal cord injury'

The deposited datasets consist in the following: Supplementary Table 1: All kinematics data and statistical analyses Supplementary Table 2: All differential analyses and statistics for the quantification of transcriptional activity (cFos) and spinal cord-projecting neurons (Rabies) from the contralesional (right) lateral hypothalamus (n = 3 per group).

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Contours of the caregiver experience: Social resources and health behaviors in caregiving partners of persons with a spinal cord injury

Background and rationale: Informal caregiving is highly prevalent in Switzerland and in the long-term associated with chronic stress as evidenced by its negative effects on caregivers health and well-being. To date, most of research on informal caregiving has been focused on the elderly. Yet, the evidence from these studies may not be applicable and misinform policy in context of physical disabilities, which may further concerns younger-aged caregivers. Spinal cord injury (SCI) is an exemplary condition for the enforced need of long-term informal care that oftentimes occurs in middle-age. To better understand the mechanisms behind the health-adverse effects of caregiving, a improved understanding of the interplay between social and behavioral factors and the caregiver experience is needed. This project was a follow-up of the longitudinal pro-WELL study (pro-WELL 1), which investigated associations of productive activities and social relationships with health and well-being in persons with SCI and their caregiving partners (SNSF Project 100017_153256/1). Using the follow-up funding by SNF (pro-WELL 2) we further explored the pro-WELL data to foster a comprehensive understanding of the caregiver experience, also to promote the discussion and transfer of the gained knowledge to stakeholders. Objectives: The overall objective of this pro-WELL follow-up study ("pro-WELL 2") was to explore the relationship of social and behavioral factors with the caregiver experience to better understand the causal pathway linking the caregiver experience with health and well-being of the caregiving partners of persons with SCI. The specific aims were to investigate 1) whether socioeconomic conditions shape the caregiver experience, 2) whether social relationships moderate the association between the caregiver experience and health, and 3) whether the caregiver experience has an effect on health behaviors in the caregiving partners of persons with SCI. Using the evidence gained by pro-WELL 1 and 2, we aimed to conduct stakeholder dialogues in order to develop strategies to support burdened caregivers within the network of the Swiss Paraplegic Group. Methods: Pro-WELL is an observational longitudinal survey with three measurement waves. Data collection was completed in January 2017 and n=133, n=123, and n=119 couples participated at baseline, month 6 and month 12, respectively. The analyses were based on longitudinal dyadic data from the caregiving partners of persons with SCI that completed at least two waves (n=123). We applied multivariable regression modelling and path analysis to explore the research questions. Results: We demonstrated that caregivers with lower socioeconomic status reported a higher burden of care (Tough, Brinkhof, Siegrist, Fekete 2020, Int J Equity Health), provided evidence that social support moderates the association between the caregiver burden and health (Tough, Brinkhof, Fekete. submitted), and showed that the caregiver burden negatively affects specific health behaviors (Tough, Brinkhof, Fekete 2020, Health Psychology Behav Med). Discussion: This study was among the first to investigate the social and behavioral factors related to the caregiver experience, and to evaluate possible pathways through which the caregiver experience may impact upon health and well-being in middle-aged caregivers of persons with a physical disability. This study identified targets for interventions aimed at improving the caregiver experience with the ultimate goal to contribute to caregivers' health and well-being. The results of the pro-WELL 2 study were used to inform stakeholder dialogues on the current needs and potential actions to improve the situation of informal caregivers in Switzerland.

opencc-zeroNov 2021View details →

opencc-by-4.0Dec 2021View details →

Comparing natural hydrogels to self-assembling peptides in spinal cord injury treatment: a systematic review

Abstract Background: In many cases, central nervous system (CNS) injury is unchanging due to the absence of neuronal regeneration and repair capabilities. In recent years, regenerative medicine, and especially hydrogels, have reached a significant amount of attention for their promising results for the treatment of spinal cord injury (SCI) currently considered permanent. Hydrogels are categorized based on their foundation: synthetic, natural, and combination. The objective of this study was to compare the properties and efficacy of commonly used hydrogels, like collagen, and other natural peptides with synthetic self-assembling peptide hydrogels in the treatment of SCI.  Methods: Articles were searched in PubMed, Scopus, Web of Science, and Embase. All studies from 1985 until January 2020 were included in the primary search. Eligible articles were included based on the following criteria: administering hydrogels (both natural and synthetic) for SCI treatment,  soley foucsing on spinal cord injury treatment, and published in a peer-reviewd journal. Data surronding xonal regeneration, revascularization, elasticity, drug delivery efficacy, and porosity were extracted. Results: A total of 24 articles were included for full-text review and data extraction. There were only one experimental study directly comparing Collagen I (as natural hydorgel) and PEG (as synthetic hydrogels) in an in vitro setting. The included study suggested PEG’s cell behavior is more expectable in the injury site, which makes it a more reliable scaffold. Conclusions: There is limited research comparing and evaluating both types of natural and self-assembling peptides (SAPs) in the same animal or in vitro study, despite its importance. Although we assume that the remodeling of natural scaffolds may lead to a stable hydrogel, there was not a definitive conclusion that synthetic hydrogels are more beneficial than natural hydrogels in neuronal regeneration.

opencc-by-4.0Jun 2024View details →

Colonic contractility recordings following spinal cord injury in mice with dietary fiber interventions

Here, we performed colonic contractility measurements in mice following spinal cord injury, with or without a dietary fiber intervention at 2 weeks post-injury. Provided here are is a .zip file containing the raw ABF measurement files necessary for analysis of the frequency and amplitude of contractions. Breifly, data were acquired using AxoClamp 900A (Axon Instruments). Each tissue segment was recorded for at least 30min in 5min gap-free files. 15min of stable recordings were selected from the middle of each recording session for analysis. Using Clampfit software (Molecular Devices, RRID:SCR_011323), data files were filtered at 300Hz (Bessel 8-pole) and reduced by a factor of 100. Files were concatenated and the baseline was adjusted based on overall slope. Amplitude was calculated by subtracting the minimum value of the whole trace from the value of the peak being assessed.

opencc-by-4.0Dec 2018View details →

A novel use of virtual reality in the treatment of cognitive and motor deficit in spinal cord injury

Aim of this study is to evaluate the cognitive and motor outcomes after a combined rehabilitative training using a standard cognitive approach and virtual reality (VR), in a patient with spinal cord injury (SCI). A 60-year-old right-handed man, affected by incomplete cervical SCI, came to our observation for a moderate tetraparesis, mainly involving the left side, after about 6-months from the acute event. The neurological examination showed imbalance with upper limb incoordination, besides the paresis mainly involving the left side. At a neuropsychological evaluation, he presented important impairment in cognitive and behavioural status, with temporal and spatial disorientation, a reduction of attention and memory process, deficit of executive function and a severe depression of mood, which was not detected during the previous recovery. Motor and cognitive deficits in SCI. The patient was 1st submitted to standard cognitive training and traditional physiotherapy, and then to a combined therapeutic approach, in which virtual reality training was provided by means of the virtual reality rehabilitation system (VRRS, Khymeia, Italy). After the combined therapeutic approach with the VRRS training, we observed a significant improvement in different cognitive domains, a notable reduction of anxiety and depressive symptoms, as well as motor performance, and balance improvement. Virtual reality can be considered a promising tool for the rehabilitation of different neurological disorders, including patients with both motor and cognitive deficits following SCI.

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Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)

Background: Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. A neuroprotective compound, ACTH4-10Pro8-Gly9-Pro10 also known as Semax has shown neuroprotective and anti-inflammatory properties. ACTH4-10Pro8-Gly9-Pro10 also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of ACTH4-10Pro8-Gly9-Pro10 in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI. Method: We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. ACTH4-10Pro8-Gly9-Pro10 was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. The preparations tissue sample were fixed in formalin and examined for immunohistochemistry. Quantitative measurement of anti-inflammatory cytokine (IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies. Result: Rats with mild SCI that were given ACTH4-10Pro8-Gly9-Pro10 shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH4-10Pro8-Gly9-Pro10 group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group. Conclusion: Administration of ACTH4-10Pro8-Gly9-Pro10 intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.

opencc-zeroDec 2022View details →

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Feasibility of using remotely delivered Spring Forest Qigong to reduce neuropathic pain in adults with spinal cord injury: A pilot study

Introduction: Approximately 69% of 299,000 Americans with spinal cord injury (SCI) suffer debilitating chronic neuropathic pain, which is intractable to treatment. The aim of this study is to determine feasibility, as the primary objective, and estimates of efficacy of a remotely delivered Qigong intervention in adults with SCI-related neuropathic pain, as the secondary objective. Methods: We recruited adults with SCI-related neuropathic pain, with SCI ≥3 months, with complete or incomplete SCI, and highest neuropathic pain level of >3 on the Numeric Pain Rating Scale (NPRS), using nationwide volunteer sampling. Using a non-randomized controlled trial design, participants practiced Spring Forest Qigong's "Five Element Qigong Healing Movements" (online video) by combining movement to the best of their ability with kinesthetic imagery, at least 3x/week for 12 weeks. Adherence was automatically tracked through the Spring Forest Qigong website. Outcomes of neuropathic pain intensity (NPRS) were assessed weekly, and SCI-related symptoms were assessed at baseline, 6, and 12 weeks of Qigong practice and at 6-week and 1-year follow-ups. Results: We recruited 23 adults with chronic SCI (7/2021–2/2023). In total, 18 participants started the study and completed all study components, including the 6-week follow-up. Twelve participants completed the 1-year follow-up assessment. Feasibility was demonstrated through participants' willingness to participate, adherence, and acceptability of the study. Mean age of the 18 participants was 60 ± 12 years, and they were 15 ± 11 years post-SCI with the highest baseline neuropathic pain of 7.94 ± 2.33, which was reduced to 4.17 ± 3.07 after 12 weeks of Qigong practice (Cohen's d = 1.75). This pain relief remained at 6-week and 1-year follow-ups. Participants reported reduced spasm frequency (change score 1.17 ± 1.20, d = 0.98) and severity (0.72 ± 1.02, d = 0.71), reduced interference of neuropathic pain on mood (3.44 ± 2.53, d = 1.36), sleep (3.39 ± 2.40, d = 1.41), daily activities (3.17 ± 2.77, d = 1.14), greater ability to perform functional activities (6.68 ± 3.07, d = 2.18), and improved mood (2.33 ± 3.31, d = 0.70) after Qigong. Discussion: Remote Spring Forest Qigong's "Five Element Qigong Healing Movements" practice is feasible in adults with SCI-related neuropathic pain, with promising prolonged results of neuropathic pain relief and improvement in SCI-related symptoms after Qigong practice. Clinical trial registration: <a href="https://www.clinicaltrials.gov/ct2/show/NCT04917107">https://www.clinicaltrials.gov/ct2/show/NCT04917107</a>, identifier NCT04917107

opencc-zeroSep 2023View details →

Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury

ClinicalTrials.gov study NCT03302793. IPD Sharing: Not stated. Countries: 1. Publications: 1.

Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury

ClinicalTrials.gov study NCT00833105. IPD Sharing: Not stated. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →

Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury

ClinicalTrials.gov study NCT03083366. IPD Sharing: NO. Countries: 1. Publications: 1.

Spinal Cord Injury Vocational Integration Program (SCI-VIP)

ClinicalTrials.gov study NCT00117806. IPD Sharing: Not stated. Countries: 1. Publications: 12.

closedIPD-NOFeb 2026View details →

Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury

ClinicalTrials.gov study NCT02878850. IPD Sharing: NO. Countries: 1. Publications: 2.

Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation

ClinicalTrials.gov study NCT03458871. IPD Sharing: Not stated. Countries: 1. Publications: 1.