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18 results for “Stem cell competition”
Radiation-Induced Stem Cell Competition and Dose-Rate Effect
<p>A radiation biological effect of a given dose generally decreases with decreasing radiation dose rate, which is known as a “dose-rate effect”. The dose-rate effect demonstrated by many cellular and animal studies. Additionally, recent epidemiological study in high background radiation area in Kerala, India showed that cancer incidence did not increase with increasing cumulative dose (Jayalekshmi et al. Radiat Environ Med 2021). Tissue stem cells have been considered as a target of radiation-induced carcinogenesis. Radiation biological effect could be reduced if damaged stem cells are eliminated by stem cell competition. ICRP described that stem cell competition at the tissue level leaves an ample possibility for a dose-rate effective factor (DREF) value larger than unity, as in the case of the current dose and dose-rate effective factor (DDREF) value (ICRP Publication 131).</p> <p>Cells expressing Lgr5 are one of the major components of intestinal stem cells. Intestinal organoids are three-dimensional cultured tissue model generated from intestinal stem cells. To evaluate a radiation-induced stem cell competition, we established a quantitative method using mixed-organoid derived from two independent fluorescent protein-expressing Lgr5 stem cells, which one of stem cells were irradiated, for mimicking heterogeneous exposure under low-dose-rate irradiation. The organoid-forming potential (OFP) is one of the indices of the abilities of self-renewal, proliferation, and differentiation of stem cells. We found that irradiated stem cells exhibited a growth disadvantage in the mixed organoid, whereas the OFP of irradiated cells per se did not decrease significantly from that of non-irradiated cells.</p> <p>Additionally, we constructed a mathematical model to assess stem cell competition under low-dose-rate irradiation condition. In our model, a stem cell pool, containing a constant number of cells, was assumed, and changed through transition and turnover event. The intact cells turned into damaged cells through transition event which was assumed as the effect of radiation exposure. In the turnover event, a single cell was divided, and a single cell was eliminated from the stem cell pool. The probability of cell division and elimination depended on the properties of cells. The properties of damaged cells were different from that of intact cells. Under very low-dose-rate conditions, the radiation damage was suppressed when the damaged cells were less reproductive and tended to be eliminated compared to the intact cells.</p> <p>These results suggest the radiation-induced stem cell competition can be occurred in the intestine, and the stem-cell competition plays an important role in suppress carcinogenesis under low-dose-rate irradiation condition.</p>
p53-mediated hematopoietic stem and progenitor cell competition
GEO Series GSE20912. Mus musculus. 12 samples. Type: Expression profiling by array.
Pax7 ablation model enables evaluation of stem cell niche formation in the absence of mouse Pax7 cell competition
GEO Series GSE241368. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
A genome-wide screen identifies competitive growth advantage for human epidermal stem cells with activated YAP
GEO Series GSE79560. Homo sapiens. 24 samples. Type: Other.
Competition between hematopoietic stem and progenitor cells controls the hematopoietic stem cell homeostasis [bulk RNA-seq]
GEO Series GSE171013. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Physiologic expression of Srsf2(P95H) causes myeloid expansion, impaired competitive stem cell function and initiates the myeloproliferative/myelodysplastic syndrome in vivo [WES]
GEO Series GSE99850. Mus musculus. 6 samples. Type: Other.
Competition between hematopoietic stem and progenitor cells controls the hematopoietic stem cell homeostasis.
GEO Series GSE171015. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Competition for mitogens regulates spermatogenic stem cell homeostasis in an open niche
GEO Series GSE118846. Mus musculus. 10 samples. Type: Expression profiling by array.
Physiologic expression of Srsf2(P95H) causes myeloid expansion, impaired competitive stem cell function and initiates the myeloproliferative/myelodysplastic syndrome in vivo.
GEO Series GSE99852. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing; Other.
TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem Cells through Upregulation of Thrombopoietin Receptor Signaling
GEO Series GSE264041. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Axin2 mediates stem cell competition in developing brain
GEO Series GSE178509. Mus musculus. 31 samples. Type: Expression profiling by high throughput sequencing.
Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells
GEO Series GSE150588. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Competition between hematopoietic stem and progenitor cells controls the hematopoietic stem cell homeostasis [scRNA-seq]
GEO Series GSE171014. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Stem cell competition orchestrates skin homeostasis and ageing
GEO Series GSE111825. Mus musculus. 6 samples. Type: Expression profiling by array.
Physiologic expression of Srsf2(P95H) causes myeloid expansion, impaired competitive stem cell function and initiates the myeloproliferative/myelodysplastic syndrome in vivo [RNA-seq]
GEO Series GSE99851. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Physiologic expression of Srsf2(P95H) causes myeloid expansion, impaired competitive stem cell function and initiates the myeloproliferative/myelodysplastic syndrome in vivo [RNA-seq2]
GEO Series GSE104976. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Cell competition regulates the fate decision of neural stem cells
GEO Series GSE223131. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Telomerase reverse transcriptase promotes stem cell competition through MYC
GEO Series GSE145659. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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