Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
34
datasets available to search
ShareScore release 0.9.0
Dataset results
34 results for “Steroidogenesis”
Data of Fig 4 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 4 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Figure 5 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 5 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Dataset of Fig 3 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 3 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
FRIEDREICH ATAXIA- STEROIDOGENESIS
ClinicalTrials.gov study NCT07123142. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis
The U.S. Environmental Protection Agency Endocrine Disruptor Screening Program and the Organization for Economic Co-operation and Development (OECD) have used the human adrenocarcinoma (H295R) cell-based assay to predict chemical perturbation of androgen and estrogen production. Recently, a high-throughput H295R (HT-H295R) assay was developed as part of the ToxCast program that includes measurement of 11 hormones, including progestagens, glucocorticoids, androgens, and estrogens. To date, 2012 chemicals have been screened at one concentration; of these, 656 chemicals have been screened in concentration-response. The objectives of this work were to: 1) develop an integrated analysis of chemical-mediated effects on steroidogenesis in the HT-H295R assay; and, 2) evaluate whether the HT-H295R assay predicts estrogen and androgen production specifically via comparison with the OECD-validated H295R assay. To support application of HT-H295R assay data to weight-of-evidence and prioritization tasks, a single numeric value based on Mahalanobis distances was computed for 654 chemicals to indicate the magnitude of effects on the synthesis of 11 hormones. The maximum mean Mahalanobis distance (maxmMd) values were high for strong modulators (prochloraz, mifepristone) and lower for moderate modulators (atrazine, molinate). Twenty-five of 28 reference chemicals used for OECD validation were screened in the HT-H295R assay, and produced qualitatively similar results, with accuracies of 0.90/0.75 and 0.81/0.91 for increased/decreased testosterone and estradiol production, respectively. The HT-H295R assay provides robust information regarding estrogen and androgen production, as well as additional hormones. The maxmMd from this integrated analysis may provide a data-driven approach to prioritizing lists of chemicals for putative effects on steroidogenesis.
Human Chorionic Gonadotropin Stimulation Effects on Steroidogenesis in Men With Klinefelter Syndrome
ClinicalTrials.gov study NCT02788136. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis
Open the record for dataset details and reuse information.
Figure 5 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 5 Histological analysis of the adrenal gland. A. Adrenal gland of control group; B. Adrenal gland of 100 mg chrysin-treated group.
Figure 2 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 2 The expression of target genes in the ovary of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating ΔCt and relative fold gene expression. * P ≤ 0.05. 3β-HSD, 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase.
Figure 1 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 1 The expression of target genes in the adrenal gland of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating ΔCt and relative fold gene expression. * P ≤ 0.05, ** P ≤ 0.01. CYP17A1, cytochrome P450 family 17 subfamily A member 1; P450scc, cholesterol side-chain cleavage enzyme; 3β-HSD, 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase.
Figure 7 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 7 Histological analysis of the adrenal gland medulla. A. Adrenal medulla of control group; B. Adrenal medulla of 100 mg chrysin-treated group.
Figure 4 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 4 Effect of chrysin on adrenal gland histology. Stained section of the control adrenal cortex showing a thin capsule (C) with underlying zona glomerulosa (G) arranged in oval or curved clusters. Zona fasciculata cells (F) are arranged in parallel cords while cells of zona reticularis (R) with anastomosing cords (H & E stain).
Figure 3 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 3 The expression of estrogen receptor-α (ERα) in the uterus of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating of ΔCt and relative fold gene expression.
Figure 6 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 6 Histological analysis of adrenal cortex. A. Adrenal cortex of the control group; B. Adrenal cortex of the 100 mg chrysin-treated group.
Adrenal Abcg1 controls cholesterol flux and steroidogenesis
GEO Series GSE242081. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A Mixture Reflecting Polybrominated Diphenyl Ether (PBDE) Profiles Detected in Human Follicular Fluid Significantly Affects Steroidogenesis and Induces Oxidative Stress in a Human Granulosa Cell L
GEO Series GSE77963. Homo sapiens. 23 samples. Type: Expression profiling by array.
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis
GEO Series GSE292877. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Hyperprolactinemia and Adrenal Steroidogenesis
ClinicalTrials.gov study NCT04146389. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Perturbing local steroidogenesis to improve breast cancer immunity
GEO Series GSE255495. Mus musculus; Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Adropin stimulates proliferation and inhibits adrenocortical steroidogenesis via the TGF-beta mediated pathway in the human adrenal carcinoma (HAC15) cell line.
GEO Series GSE150775. Homo sapiens. 16 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.