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60 results for “Streptomyces coelicolor”
Data from: Identification of glucose kinase dependent and independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics
Members of the soil-dwelling prokaryotic genus Streptomyces are indispensable for the recycling of complex polysaccharides, and produce a wide range of natural products. Nutrient availability is a major determinant for the switch to development and antibiotic production in streptomycetes. Carbon catabolite repression (CCR), a main signaling pathway underlying this phenomenon, was so far considered fully dependent on the glycolytic enzyme glucose kinase (Glk). Here we provide evidence of a novel Glk-independent pathway in Streptomyces coelicolor, using advanced proteomics that allowed the comparison of the expression of some 2,000 proteins, including virtually all enzymes for central metabolism. While CCR and inducer exclusion of enzymes for primary and secondary metabolism and precursor supply for natural products is mostly mediated via Glk, enzymes for the urea cycle, as well as for biosynthesis of the γ-butyrolactone Scb1 and the responsive cryptic polyketide Cpk are subject to Glk-independent CCR. Deletion of glkA led to strong downregulation of biosynthetic proteins for prodigionin and calcium-dependent antibiotic (CDA) in mannitol-grown cultures. Repression of bldB, bldN, and its target bldM explains the poor development of S. coelicolor on solid-grown cultures containing glucose. A new model for carbon catabolite repression in streptomycetes is presented.
Data from: Identification of glucose kinase dependent and independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics
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RNA-Seq analysis reveals a six-gene SoxR regulon in Streptomyces coelicolor
GEO Series GSE57268. Streptomyces coelicolor. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide binding site profiling of NdgR in Streptomyces coelicolor
GEO Series GSE59010. Streptomyces coelicolor. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Effects of cAMP supplementation on the transcriptome of Streptomyces coelicolor M145 strain
GEO Series GSE158810. Streptomyces coelicolor. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiles of Streptomyces coelicolor A3(2) wild type treated with kanamycin and iron
GEO Series GSE168567. Streptomyces coelicolor. 8 samples. Type: Expression profiling by high throughput sequencing.
Time-course transcriptome analysis of non-antibiotics producer and actinorhodin over-producing Streptomyces coelicolor strain
GEO Series GSE155796. Streptomyces coelicolor. 20 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide identification of WblC (WhiB7) binding sites in Streptomyces coelicolor A3(2) treated with tetracycline
GEO Series GSE136166. Streptomyces coelicolor. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Streptomyces coelicolor M600 BldD ChIP-chip comparison of wild-type with bldD null mutant
GEO Series GSE23401. Streptomyces coelicolor. 4 samples. Type: Genome binding/occupancy profiling by array.
Expression time-series from Streptomyces coelicolor germination
GEO Series GSE44415. Streptomyces coelicolor A3(2). 37 samples. Type: Expression profiling by array.
Gene expression in a Streptomyces coelicolor strain defective in sco1423 encoding a polyprenol phosphate mannose synthase (Ppm1) compared to the complemented mutant and the wild type parent
GEO Series GSE107982. Streptomyces coelicolor A3(2). 9 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of Streptomyces coelicolor Cvn8 mutants on ISP2 agar in isolation or in an interaction [2020RNAseqData]
GEO Series GSE167965. Streptomyces coelicolor. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiles of Streptomyces coelicolor A3(2) wild type and wblC (whiB7) mutant treated with tetracycline
GEO Series GSE136167. Streptomyces coelicolor. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of Streptomyces coelicolor Cvn8 mutants on ISP2 agar in isolation or in an interaction
GEO Series GSE167966. Streptomyces coelicolor. 42 samples. Type: Expression profiling by high throughput sequencing.
Effects of cAMP supplementation on the transcriptome of Streptomyces coelicolor M1146 strain
GEO Series GSE158811. Streptomyces coelicolor. 9 samples. Type: Expression profiling by high throughput sequencing.
Time course of Streptomyces coelicolor: M145 Control vs. wblA deletion mutant
GEO Series GSE24396. Streptomyces coelicolor. 6 samples. Type: Expression profiling by array.
Deletion of MtrA inhibits cellular development of Streptomyces coelicolor and alters expression of developmental regulatory genes
GEO Series GSE104263. Streptomyces coelicolor. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome and translatome landscape of Streptomyces coelicolor M145
GEO Series GSE69350. Streptomyces coelicolor. 14 samples. Type: Expression profiling by high throughput sequencing; Other.
Cytosolic copper concentration modulates spore germination and secondary metabolism in Streptomyces coelicolor
GEO Series GSE111126. Streptomyces coelicolor. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-Sequencing of Streptomyces coelicolor A3(2) (M145) in timeseries
GEO Series GSE132487. Streptomyces coelicolor A3(2). 27 samples. Type: Expression profiling by high throughput sequencing.
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