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15 results for “Strongyloidiasis”
Metabolic alterations in Strongyloidiasis stool samples unveil potential biomarkers of infection_dataset
<p>Strongyloidiasis, a parasitosis caused by <em>Strongyloides stercoralis</em> in humans, is a very prevalent infection in tropical or subtropical areas. Gaps on public health strategies corroborates to the high global incidence of strongyloidiasis especially due to challenges involved on its diagnosis. Based on the lack of a gold-standard diagnostic tool, we aimed to present a metabolomic study for the assessment of stool metabolic alterations. Stool samples were collected from 25 patients segregated into positive for strongyloidiasis (n = 10) and negative control (n = 15) and prepared for direct injection high-resolution mass spectrometry analysis. Using metabolomics workflow, 18 metabolites were annotated increased or decreased in strongyloidiasis condition, from which a group of 5 biomarkers comprising caprylic acid, mannitol, glucose, lysophosphatidylinositol and hydroxy-dodecanoic acid demonstrated accuracy over 89% to be explored as potential markers. The observed metabolic alteration in stool samples indicates involvement of microbiota remodeling, parasite constitution, and host response during <em>S. stercoralis</em> infection.</p>
Fig. 2 in Strongyloidiasis in humans and dogs in Southern Italy: an observational study
Fig. 2 (MAP 2): Geographic distribution of positive dogs (n=6) and humans (n=9). Different colours as in map 1 are indicative of the different habits (red= kennels, blue= agricultural farms; violet= livestock farm). None of the kennels/farms positive for dogs were positive for humans and vice-versa
Fig. 1 in Strongyloidiasis in humans and dogs in Southern Italy: an observational study
Fig. 1 (MAP 1): Distribution of sampled farms and kennels differentiated by colours (red=kennels; violet=livestock farms; Blue=agricultural farms)
Figure 5 in Improved diagnostic sensitivity of human strongyloidiasis using point-of-care mixed recombinant antigen-based immunochromatography
Figure 5. The intensity values of NIE (a), SsIR (b), and NIE-SsIR (c) ICT kits were evaluated using an in-house strip reader (red line indicates cut-off intensity value). Groups I, II, and III represented healthy controls, proven strongyloidiasis, and other parasitic infections, respectively. Any value above the cut-off value (red horizontal lines) is negative. Receiver operator characteristic (ROC) area analyses of the NIE, SsIR, and NIE-SsIR ICT kits to compare accuracy of all kits with gold standard methods (d).
Figure 3 in Improved diagnostic sensitivity of human strongyloidiasis using point-of-care mixed recombinant antigen-based immunochromatography
Figure 3. The purified NIE (a) and SsIR (b) fusion-tagged proteins visualized following electrophoresis through 12% and 10% SDS–PAGE, respectively. The gels were stained with Coomassie Brilliant Blue. Representative dot ELISAs (c) using NIE (1–2), SsIR (3–4), and mixed NIE and SsIR (5–6) proteins as the antigens probed with pooled positive (1, 3, 5) and negative (2, 4, 6) sera. M indicates molecular mass maker.
Figure 1 in Improved diagnostic sensitivity of human strongyloidiasis using point-of-care mixed recombinant antigen-based immunochromatography
Figure 1. Flow diagram of study design for the NIE, SsIR, and NIE-SsIR ICT kits. The SsIR ICT kit procedure was performed as previously described by Boonroumkaew et al. [4].
Figure 2 in Improved diagnostic sensitivity of human strongyloidiasis using point-of-care mixed recombinant antigen-based immunochromatography
Figure 2. The parts of an ICT kit (left) and reference colour card (right) (a). An ICT kit showing a positive result (b) with a band at both control (C) and test (T) lines. An ICT kit showing a negative result (c) with a band only at the C line. The intensity value of the colour image is specified by the red, green, and blue parameters as separate integers from 0 to 255 with the 8-bit representation of a pixel in the image. The intensity values were plotted for C and T lines of the positive (d) and negative (e) ICT kits. The intensity values (d and e) were related to colour band intensity of C and T lines in the strips. S indicates sample hole.
Figure 4 in Improved diagnostic sensitivity of human strongyloidiasis using point-of-care mixed recombinant antigen-based immunochromatography
Figure 4. Representative results of the NIE, SsIR, and NIE-SsIR ICT kits, Positive, positive pooled serum samples; Negative, negative pooled serum samples; Hc, healthy control; Ss, proven strongyloidiasis; Gl, giardiasis; Eh, amoebiasis; Bh, blastocystosis; Ov, opisthorchiasis; Fg, fascioliasis; Ph, paragonimiasis; Tn, taeniasis; Cc, cysticercosis; Se, sparganosis; Hw, hookworm infections; Al, ascariasis; Tt, trichuriasis; Ts, trichinellosis; Ac, angiostrongyliasis; Gs, gnathostomiasis; Cp, capillariasis. The intensity cut-off levels for a positive result of the NIE, SsIR, and NIE-SsIR ICT kits were 1, 1, and>0.5, respectively by the naked eye and <164, <164, and <167, respectively by the in-house strip reader. The "+" and "—" symbols indicated positive and negative results.
Fig. 1 Screening flow, testing 1600 FDA compounds against S in Assessment of FDA-approved drugs against StrongyloideS rAtti in vitro and in vivo to identify potentially active drugs against strongyloidiasis
Fig. 1 Screening flow, testing 1600 FDA compounds against S. ratti
Ivermectin Versus Albendazole for Chronic Strongyloidiasis
ClinicalTrials.gov study NCT00765024. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis
ClinicalTrials.gov study NCT01570504. IPD Sharing: NO. Countries: 3. Publications: 1.
Efficacy and Safety of Emodepside in Adults Infected With Strongyloidiasis Stercoralis
ClinicalTrials.gov study NCT06373835. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Strongyloidiasis in Ecuador: a fieLd Laboratory Accuracy Study
ClinicalTrials.gov study NCT04999774. IPD Sharing: YES. Countries: 1. Publications: 0.
Strongyloidiasis at CHRU Nancy: Evaluation of the Performance of Serological Tests and Disease-associated Characteristics
ClinicalTrials.gov study NCT07296198. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Management of Soil-transmitted Helminthiasis and Strongyloidiasis
ClinicalTrials.gov study NCT01308268. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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